BRD-K88510285_B675700.cdx_NCIH596_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

147 genes differentially expressed following the BRD-K88510285_B675700.cdx_NCIH596_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
BCAM basal cell adhesion molecule (Lutheran blood group)
C3 complement component 3
CA2 carbonic anhydrase II
CALML3 calmodulin-like 3
CCL20 chemokine (C-C motif) ligand 20
CLDND1 claudin domain containing 1
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CSRP1 cysteine and glycine-rich protein 1
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FAM129A family with sequence similarity 129, member A
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
GADD45A growth arrest and DNA-damage-inducible, alpha
GAGE3 G antigen 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB2 homeobox B2
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HYOU1 hypoxia up-regulated 1
IER3 immediate early response 3
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL32 interleukin 32
IPO13 importin 13
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KDM6A lysine (K)-specific demethylase 6A
MAN1A1 mannosidase, alpha, class 1A, member 1
MBTPS1 membrane-bound transcription factor peptidase, site 1
MMP2 matrix metallopeptidase 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PEG10 paternally expressed 10
PIEZO1 piezo-type mechanosensitive ion channel component 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMM2 phosphomannomutase 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RGCC regulator of cell cycle
SERINC5 serine incorporator 5
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SHB Src homology 2 domain containing adaptor protein B
SMC1A structural maintenance of chromosomes 1A
SOCS1 suppressor of cytokine signaling 1
SOD2 superoxide dismutase 2, mitochondrial
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRIB3 tribbles pseudokinase 3
VTCN1 V-set domain containing T cell activation inhibitor 1
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADGRG2 adhesion G protein-coupled receptor G2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALOX5 arachidonate 5-lipoxygenase
AMDHD2 amidohydrolase domain containing 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ASCL1 achaete-scute family bHLH transcription factor 1
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
CCDC85B coiled-coil domain containing 85B
CCND1 cyclin D1
CD24 CD24 molecule
CDC25B cell division cycle 25B
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHPT1 choline phosphotransferase 1
CSTB cystatin B (stefin B)
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EDNRB endothelin receptor type B
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FBXO21 F-box protein 21
FZD7 frizzled class receptor 7
GMDS GDP-mannose 4,6-dehydratase
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
HOXA10 homeobox A10
IGFBP3 insulin-like growth factor binding protein 3
IRS2 insulin receptor substrate 2
KANK1 KN motif and ankyrin repeat domains 1
KDM5D lysine (K)-specific demethylase 5D
MAB21L2 mab-21-like 2 (C. elegans)
MAMLD1 mastermind-like domain containing 1
MET MET proto-oncogene, receptor tyrosine kinase
MRPS2 mitochondrial ribosomal protein S2
NEBL nebulette
NFIB nuclear factor I/B
NPM3 nucleophosmin/nucleoplasmin 3
NPY neuropeptide Y
NR2F1 nuclear receptor subfamily 2, group F, member 1
NRN1 neuritin 1
OLFM1 olfactomedin 1
PAX5 paired box 5
PDLIM2 PDZ and LIM domain 2 (mystique)
PEBP1 phosphatidylethanolamine binding protein 1
PRKCZ protein kinase C, zeta
PROM1 prominin 1
PRR7 proline rich 7 (synaptic)
PRSS23 protease, serine, 23
PTGES prostaglandin E synthase
PXMP2 peroxisomal membrane protein 2, 22kDa
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPS11 ribosomal protein S11
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC16A4 solute carrier family 16, member 4
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SORD sorbitol dehydrogenase
SOX9 SRY (sex determining region Y)-box 9
SPTBN1 spectrin, beta, non-erythrocytic 1
STOM stomatin
TACC2 transforming, acidic coiled-coil containing protein 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TSKU tsukushi, small leucine rich proteoglycan
TSPAN4 tetraspanin 4
TSPAN8 tetraspanin 8
UPK1B uroplakin 1B