BRD-K88510285_B675700.cdx_NCIH2073_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-K88510285_B675700.cdx_NCIH2073_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA1 actin, alpha 1, skeletal muscle
ADCK3 aarF domain containing kinase 3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CCL2 chemokine (C-C motif) ligand 2
CD40 CD40 molecule, TNF receptor superfamily member 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CKM creatine kinase, muscle
CLIC4 chloride intracellular channel 4
CLU clusterin
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL5A2 collagen, type V, alpha 2
COL8A2 collagen, type VIII, alpha 2
CRYAB crystallin, alpha B
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT4 DNA-damage-inducible transcript 4
DGKA diacylglycerol kinase, alpha 80kDa
DIXDC1 DIX domain containing 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPT dermatopontin
DST dystonin
EAPP E2F-associated phosphoprotein
FKBP14 FK506 binding protein 14, 22 kDa
FXYD3 FXYD domain containing ion transport regulator 3
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GBP1 guanylate binding protein 1, interferon-inducible
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
IDO1 indoleamine 2,3-dioxygenase 1
ITPKB inositol-trisphosphate 3-kinase B
KLK5 kallikrein-related peptidase 5
KRT15 keratin 15, type I
LRRC15 leucine rich repeat containing 15
LTF lactotransferrin
MAN2A1 mannosidase, alpha, class 2A, member 1
MAOB monoamine oxidase B
MAP7 microtubule-associated protein 7
MB myoglobin
MERTK MER proto-oncogene, tyrosine kinase
MICALL1 MICAL-like 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP9 matrix metallopeptidase 9
NFIL3 nuclear factor, interleukin 3 regulated
NID1 nidogen 1
NQO2 NAD(P)H dehydrogenase, quinone 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCP4 Purkinje cell protein 4
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PHGDH phosphoglycerate dehydrogenase
PLXNB2 plexin B2
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SERTAD2 SERTA domain containing 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TARP TCR gamma alternate reading frame protein
TARS threonyl-tRNA synthetase
TBX3 T-box 3
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TPM4 tropomyosin 4
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3
ZBED2 zinc finger, BED-type containing 2
ZNF430 zinc finger protein 430
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ATG3 autophagy related 3
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CDC20 cell division cycle 20
CENPA centromere protein A
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL14 chemokine (C-X-C motif) ligand 14
CYBA cytochrome b-245, alpha polypeptide
DEFB1 defensin, beta 1
DOK4 docking protein 4
FGB fibrinogen beta chain
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FRZB frizzled-related protein
FXYD2 FXYD domain containing ion transport regulator 2
GNAS GNAS complex locus
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX2 glutathione peroxidase 2
GRIA2 glutamate receptor, ionotropic, AMPA 2
HN1 hematological and neurological expressed 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDI1 isopentenyl-diphosphate delta isomerase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KIF20A kinesin family member 20A
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS4 lectin, galactoside-binding, soluble, 4
MECOM MDS1 and EVI1 complex locus
MGLL monoglyceride lipase
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
OLFM4 olfactomedin 4
PDGFA platelet-derived growth factor alpha polypeptide
PGD phosphogluconate dehydrogenase
PLBD1 phospholipase B domain containing 1
PLIN2 perilipin 2
PLK1 polo-like kinase 1
PNMA2 paraneoplastic Ma antigen 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PTCH1 patched 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RBP1 retinol binding protein 1, cellular
RNH1 ribonuclease/angiogenin inhibitor 1
RPP25 ribonuclease P/MRP 25kDa subunit
SEPT9 septin 9
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLIRP SRA stem-loop interacting RNA binding protein
SMAD3 SMAD family member 3
SRGN serglycin
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TM4SF4 transmembrane 4 L six family member 4
TXNDC9 thioredoxin domain containing 9
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WEE1 WEE1 G2 checkpoint kinase