BRD-K88510285_B675700.cdx_MCF7_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K88510285_B675700.cdx_MCF7_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BLVRB biliverdin reductase B
BTG3 BTG family, member 3
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CAPN2 calpain 2, (m/II) large subunit
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCND2 cyclin D2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF1 eukaryotic translation initiation factor 1
EREG epiregulin
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
JAG1 jagged 1
JUN jun proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KLF4 Kruppel-like factor 4 (gut)
KLHDC10 kelch domain containing 10
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MTSS1 metastasis suppressor 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PIR pirin (iron-binding nuclear protein)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
RGCC regulator of cell cycle
RND3 Rho family GTPase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRD T cell receptor delta locus
TSC22D3 TSC22 domain family, member 3
TXNL4B thioredoxin-like 4B
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
ALCAM activated leukocyte cell adhesion molecule
AOX1 aldehyde oxidase 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AURKA aurora kinase A
B3GNT1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNF cyclin F
CDC25A cell division cycle 25A
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
EIF5A eukaryotic translation initiation factor 5A
GATA3 GATA binding protein 3
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
HES1 hes family bHLH transcription factor 1
HOPX HOP homeobox
HOXA5 homeobox A5
HOXC10 homeobox C10
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFITM2 interferon induced transmembrane protein 2
IRX5 iroquois homeobox 5
JADE2 jade family PHD finger 2
KRT7 keratin 7, type II
MARCKSL1 MARCKS-like 1
NFIB nuclear factor I/B
NPY neuropeptide Y
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PIP prolactin-induced protein
PLK1 polo-like kinase 1
PRR7 proline rich 7 (synaptic)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGES prostaglandin E synthase
RPS11 ribosomal protein S11
SFN stratifin
SHCBP1 SHC SH2-domain binding protein 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLIRP SRA stem-loop interacting RNA binding protein
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TSPAN13 tetraspanin 13
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon