BRD-K88510285_B675700.cdx_LOVO_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

132 genes differentially expressed following the BRD-K88510285_B675700.cdx_LOVO_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDND1 claudin domain containing 1
COL5A2 collagen, type V, alpha 2
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPT dermatopontin
DUSP1 dual specificity phosphatase 1
EIF5A eukaryotic translation initiation factor 5A
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FKBP14 FK506 binding protein 14, 22 kDa
FOSL1 FOS-like antigen 1
FOXF2 forkhead box F2
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLC glutamate-cysteine ligase, catalytic subunit
GDF15 growth differentiation factor 15
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFRD1 interferon-related developmental regulator 1
IPO13 importin 13
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NFIL3 nuclear factor, interleukin 3 regulated
NQO1 NAD(P)H dehydrogenase, quinone 1
PLAUR plasminogen activator, urokinase receptor
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGCC regulator of cell cycle
SCG5 secretogranin V
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SIK1 salt-inducible kinase 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZNF165 zinc finger protein 165

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGTR1 angiotensin II receptor, type 1
AOX1 aldehyde oxidase 1
APOD apolipoprotein D
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
BLVRA biliverdin reductase A
CA12 carbonic anhydrase XII
CAST calpastatin
CCDC109B coiled-coil domain containing 109B
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCND1 cyclin D1
CD59 CD59 molecule, complement regulatory protein
CHMP2A charged multivesicular body protein 2A
CXCL9 chemokine (C-X-C motif) ligand 9
CYB5A cytochrome b5 type A (microsomal)
CYBA cytochrome b-245, alpha polypeptide
DACH1 dachshund family transcription factor 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
F12 coagulation factor XII (Hageman factor)
FABP4 fatty acid binding protein 4, adipocyte
FBP1 fructose-1,6-bisphosphatase 1
FHL1 four and a half LIM domains 1
HOXA10 homeobox A10
IGFBP4 insulin-like growth factor binding protein 4
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRF8 interferon regulatory factor 8
KAZN kazrin, periplakin interacting protein
KCTD12 potassium channel tetramerization domain containing 12
KLK11 kallikrein-related peptidase 11
LEPR leptin receptor
MARCKS myristoylated alanine-rich protein kinase C substrate
METRN meteorin, glial cell differentiation regulator
MGLL monoglyceride lipase
MGST2 microsomal glutathione S-transferase 2
MLEC malectin
MVP major vault protein
NME3 NME/NM23 nucleoside diphosphate kinase 3
OXTR oxytocin receptor
PEBP1 phosphatidylethanolamine binding protein 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRR7 proline rich 7 (synaptic)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PXMP2 peroxisomal membrane protein 2, 22kDa
RBM47 RNA binding motif protein 47
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
STMN1 stathmin 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGM2 transglutaminase 2
TLR4 toll-like receptor 4
TMEM243 transmembrane protein 243, mitochondrial
TNIP1 TNFAIP3 interacting protein 1
TNS1 tensin 1
TSPAN3 tetraspanin 3
TSPAN4 tetraspanin 4
ZCCHC24 zinc finger, CCHC domain containing 24