BRD-K88510285_B675700.cdx_JHUEM2_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

153 genes differentially expressed following the BRD-K88510285_B675700.cdx_JHUEM2_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
ADM adrenomedullin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BTG2 BTG family, member 2
C3 complement component 3
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CRISP3 cysteine-rich secretory protein 3
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EVI2A ecotropic viral integration site 2A
FILIP1L filamin A interacting protein 1-like
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GDF15 growth differentiation factor 15
GRB7 growth factor receptor-bound protein 7
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IFI16 interferon, gamma-inducible protein 16
IGFBP5 insulin-like growth factor binding protein 5
IL32 interleukin 32
IPO13 importin 13
ITM2C integral membrane protein 2C
JUN jun proto-oncogene
LEF1 lymphoid enhancer-binding factor 1
LRMP lymphoid-restricted membrane protein
LYZ lysozyme
MAP7 microtubule-associated protein 7
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MT1E metallothionein 1E
MT1F metallothionein 1F
MYRF myelin regulatory factor
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
OSER1 oxidative stress responsive serine-rich 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PLK2 polo-like kinase 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RGCC regulator of cell cycle
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SNX13 sorting nexin 13
SULF1 sulfatase 1
SYNJ2 synaptojanin 2
TES testin LIM domain protein
THBS1 thrombospondin 1
TPD52L1 tumor protein D52-like 1
TTLL7 tubulin tyrosine ligase-like family member 7
TXNL4B thioredoxin-like 4B
UFD1L ubiquitin fusion degradation 1 like (yeast)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ADRA2A adrenoceptor alpha 2A
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
CA12 carbonic anhydrase XII
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND1 cyclin D1
CCNF cyclin F
CD36 CD36 molecule (thrombospondin receptor)
CDC42 cell division cycle 42
CDKN2A cyclin-dependent kinase inhibitor 2A
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CHRDL1 chordin-like 1
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
CYB5A cytochrome b5 type A (microsomal)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
FSTL1 follistatin-like 1
GPX3 glutathione peroxidase 3
GSTA4 glutathione S-transferase alpha 4
HAT1 histone acetyltransferase 1
HN1 hematological and neurological expressed 1
HNRNPL heterogeneous nuclear ribonucleoprotein L
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KLK11 kallikrein-related peptidase 11
KRT10 keratin 10, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LEPR leptin receptor
LPL lipoprotein lipase
LYPLA1 lysophospholipase I
MAGED1 melanoma antigen family D1
MLEC malectin
MSX1 msh homeobox 1
NFIB nuclear factor I/B
NUP62 nucleoporin 62kDa
PLAGL1 pleiomorphic adenoma gene-like 1
PLK1 polo-like kinase 1
PNMA1 paraneoplastic Ma antigen 1
PRAF2 PRA1 domain family, member 2
PRDX4 peroxiredoxin 4
PSIP1 PC4 and SFRS1 interacting protein 1
PUF60 poly-U binding splicing factor 60KDa
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A7 S100 calcium binding protein A7
SEPHS1 selenophosphate synthetase 1
SET SET nuclear proto-oncogene
SETBP1 SET binding protein 1
SFN stratifin
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLIRP SRA stem-loop interacting RNA binding protein
SLIT2 slit homolog 2 (Drosophila)
SLPI secretory leukocyte peptidase inhibitor
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRPX sushi-repeat containing protein, X-linked
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
TLR4 toll-like receptor 4
TSPAN3 tetraspanin 3
TYRP1 tyrosinase-related protein 1
UBE2S ubiquitin-conjugating enzyme E2S
ZNF586 zinc finger protein 586