BRD-K88510285_B675700.cdx_HT29_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

153 genes differentially expressed following the BRD-K88510285_B675700.cdx_HT29_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BLMH bleomycin hydrolase
C3 complement component 3
CARS cysteinyl-tRNA synthetase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLU clusterin
COCH cochlin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EIF1 eukaryotic translation initiation factor 1
EIF5 eukaryotic translation initiation factor 5
ELOVL5 ELOVL fatty acid elongase 5
EPRS glutamyl-prolyl-tRNA synthetase
EZR ezrin
FASTKD5 FAST kinase domains 5
FHL2 four and a half LIM domains 2
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GPATCH8 G patch domain containing 8
GRB10 growth factor receptor-bound protein 10
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IARS isoleucyl-tRNA synthetase
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUND jun D proto-oncogene
KLF9 Kruppel-like factor 9
KRT13 keratin 13, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NPC1 Niemann-Pick disease, type C1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OSER1 oxidative stress responsive serine-rich 1
PER1 period circadian clock 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PITX1 paired-like homeodomain 1
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RSRC2 arginine/serine-rich coiled-coil 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SIK1 salt-inducible kinase 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQSTM1 sequestosome 1
TARS threonyl-tRNA synthetase
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRIB1 tribbles pseudokinase 1
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ALDOB aldolase B, fructose-bisphosphate
ANXA4 annexin A4
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
B3GNT1
BCL2L1 BCL2-like 1
BMP4 bone morphogenetic protein 4
CCND1 cyclin D1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDB2 damage-specific DNA binding protein 2, 48kDa
DHRS1 dehydrogenase/reductase (SDR family) member 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ELOVL6 ELOVL fatty acid elongase 6
ERBB2 erb-b2 receptor tyrosine kinase 2
FBP1 fructose-1,6-bisphosphatase 1
FKBP10 FK506 binding protein 10, 65 kDa
GATA2 GATA binding protein 2
GTF3A general transcription factor IIIA
HIST1H2BD histone cluster 1, H2bd
HOXA10 homeobox A10
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ISG15 ISG15 ubiquitin-like modifier
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS4 lectin, galactoside-binding, soluble, 4
MMD monocyte to macrophage differentiation-associated
MRPL57 mitochondrial ribosomal protein L57
NES nestin
NKG7 natural killer cell granule protein 7
OLFM4 olfactomedin 4
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLBD1 phospholipase B domain containing 1
PRR7 proline rich 7 (synaptic)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SCAND1 SCAN domain containing 1
SLC35E2B solute carrier family 35, member E2B
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF4 transmembrane 4 L six family member 4
TMEM223 transmembrane protein 223
TP53I3 tumor protein p53 inducible protein 3
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TSPAN12 tetraspanin 12
ZNF580 zinc finger protein 580