BRD-K88510285_B675700.cdx_HEPG2_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

130 genes differentially expressed following the BRD-K88510285_B675700.cdx_HEPG2_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK14 cyclin-dependent kinase 14
CHIC2 cysteine-rich hydrophobic domain 2
CLU clusterin
CPB1 carboxypeptidase B1 (tissue)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
EIF5 eukaryotic translation initiation factor 5
FASTKD5 FAST kinase domains 5
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGFR2 fibroblast growth factor receptor 2
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FTH1 ferritin, heavy polypeptide 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPH1 heat shock 105kDa/110kDa protein 1
JUN jun proto-oncogene
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC4 mucin 4, cell surface associated
MYOF myoferlin
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
OSER1 oxidative stress responsive serine-rich 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SGK1 serum/glucocorticoid regulated kinase 1
SH3YL1 SH3 and SYLF domain containing 1
SHB Src homology 2 domain containing adaptor protein B
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
STATH statherin
TES testin LIM domain protein
TLK2 tousled-like kinase 2
TRIB3 tribbles pseudokinase 3
TXNDC9 thioredoxin domain containing 9
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UFD1L ubiquitin fusion degradation 1 like (yeast)

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHCY adenosylhomocysteinase
B3GNT1
BEX1 brain expressed, X-linked 1
CCNF cyclin F
CKLF chemokine-like factor
COCH cochlin
COX11 COX11 cytochrome c oxidase copper chaperone
CPNE1 copine I
CTSC cathepsin C
CXCL14 chemokine (C-X-C motif) ligand 14
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDAH1 dimethylarginine dimethylaminohydrolase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
EMP2 epithelial membrane protein 2
F12 coagulation factor XII (Hageman factor)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
FSTL1 follistatin-like 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
HLF hepatic leukemia factor
HN1 hematological and neurological expressed 1
HP haptoglobin
IER3 immediate early response 3
IFITM2 interferon induced transmembrane protein 2
IL1RAP interleukin 1 receptor accessory protein
KRT19 keratin 19, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPL lipoprotein lipase
LYPLA1 lysophospholipase I
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MARCKSL1 MARCKS-like 1
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
NFIB nuclear factor I/B
NPY neuropeptide Y
NR2F1 nuclear receptor subfamily 2, group F, member 1
NRN1 neuritin 1
PCDH9 protocadherin 9
PDLIM2 PDZ and LIM domain 2 (mystique)
PEBP1 phosphatidylethanolamine binding protein 1
PLA2G16 phospholipase A2, group XVI
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
PNMA2 paraneoplastic Ma antigen 2
POSTN periostin, osteoblast specific factor
PRR7 proline rich 7 (synaptic)
PRSS3 protease, serine, 3
PXMP2 peroxisomal membrane protein 2, 22kDa
QPRT quinolinate phosphoribosyltransferase
RBP4 retinol binding protein 4, plasma
RELN reelin
RPS11 ribosomal protein S11
SCAND1 SCAN domain containing 1
SEPP1 selenoprotein P, plasma, 1
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SORBS3 sorbin and SH3 domain containing 3
SOX4 SRY (sex determining region Y)-box 4
SRPX sushi-repeat containing protein, X-linked
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TXLNA taxilin alpha
TYRP1 tyrosinase-related protein 1
WIF1 WNT inhibitory factor 1