BRD-K88510285_B675700.cdx_HCC515_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K88510285_B675700.cdx_HCC515_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BHLHE41 basic helix-loop-helix family, member e41
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLC Charcot-Leyden crystal galectin
DEFA4 defensin, alpha 4, corticostatin
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
ESR1 estrogen receptor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NEFH neurofilament, heavy polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
NRIP3 nuclear receptor interacting protein 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
SV2C synaptic vesicle glycoprotein 2C
TAC1 tachykinin, precursor 1
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH9A1 aldehyde dehydrogenase 9 family, member A1
ANXA3 annexin A3
ASPH aspartate beta-hydroxylase
AXL AXL receptor tyrosine kinase
C2CD5 C2 calcium-dependent domain containing 5
C7 complement component 7
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CTSC cathepsin C
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPCAM epithelial cell adhesion molecule
ERLIN1 ER lipid raft associated 1
FAM57A family with sequence similarity 57, member A
FHL1 four and a half LIM domains 1
GRB14 growth factor receptor-bound protein 14
GSTM3 glutathione S-transferase mu 3 (brain)
HES1 hes family bHLH transcription factor 1
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGFBP3 insulin-like growth factor binding protein 3
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
MARCKSL1 MARCKS-like 1
MGP matrix Gla protein
NBEA neurobeachin
NES nestin
NFIB nuclear factor I/B
PCGF2 polycomb group ring finger 2
PEG10 paternally expressed 10
PLA2G16 phospholipase A2, group XVI
PRKCB protein kinase C, beta
PTGIS prostaglandin I2 (prostacyclin) synthase
PXDN peroxidasin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBPMS RNA binding protein with multiple splicing
SFRP1 secreted frizzled-related protein 1
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SYNM synemin, intermediate filament protein
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP1 TIMP metallopeptidase inhibitor 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TSPAN8 tetraspanin 8
XIST X inactive specific transcript (non-protein coding)