BRD-K88510285_B675700.cdx_HCC515_24.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

424 genes differentially expressed following the BRD-K88510285_B675700.cdx_HCC515_24.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADAM17 ADAM metallopeptidase domain 17
ADAM8 ADAM metallopeptidase domain 8
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIM2 absent in melanoma 2
AKAP17A A kinase (PRKA) anchor protein 17A
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AP1G1 adaptor-related protein complex 1, gamma 1 subunit
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
BAG3 BCL2-associated athanogene 3
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BSDC1 BSD domain containing 1
CALCOCO2 calcium binding and coiled-coil domain 2
CBR3 carbonyl reductase 3
CCL20 chemokine (C-C motif) ligand 20
CD4 CD4 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLDN8 claudin 8
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5R1 cytochrome b5 reductase 1
CYLD cylindromatosis (turban tumor syndrome)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DEFA4 defensin, alpha 4, corticostatin
DHDDS dehydrodolichyl diphosphate synthase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP1 dual specificity phosphatase 1
EAPP E2F-associated phosphoprotein
EIF5 eukaryotic translation initiation factor 5
ERP44 endoplasmic reticulum protein 44
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GEM GTP binding protein overexpressed in skeletal muscle
GHITM growth hormone inducible transmembrane protein
GLA galactosidase, alpha
GOLGB1 golgin B1
GRB10 growth factor receptor-bound protein 10
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
IFRD1 interferon-related developmental regulator 1
IGHMBP2 immunoglobulin mu binding protein 2
IL36G interleukin 36, gamma
IRF1 interferon regulatory factor 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITCH itchy E3 ubiquitin protein ligase
KCMF1 potassium channel modulatory factor 1
KIAA0368 KIAA0368
KLHL24 kelch-like family member 24
KRT6A keratin 6A, type II
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LARP6 La ribonucleoprotein domain family, member 6
LEF1 lymphoid enhancer-binding factor 1
LGALS8 lectin, galactoside-binding, soluble, 8
LIN37 lin-37 DREAM MuvB core complex component
LTF lactotransferrin
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAN2B1 mannosidase, alpha, class 2B, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP7 matrix metallopeptidase 7
MPPED2 metallophosphoesterase domain containing 2
NCF2 neutrophil cytosolic factor 2
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEFM neurofilament, medium polypeptide
NFE2L1 nuclear factor, erythroid 2-like 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
OPTN optineurin
OSBPL2 oxysterol binding protein-like 2
OSER1 oxidative stress responsive serine-rich 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PELI1 pellino E3 ubiquitin protein ligase 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PKP1 plakophilin 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PNRC1 proline-rich nuclear receptor coactivator 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PSAP prosaposin
PSEN1 presenilin 1
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSME4 proteasome (prosome, macropain) activator subunit 4
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RIPK2 receptor-interacting serine-threonine kinase 2
RNF19B ring finger protein 19B
RTCA RNA 3'-terminal phosphate cyclase
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC24A SEC24 family member A
SELE selectin E
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFTPB surfactant protein B
SH3BGR SH3 domain binding glutamate-rich protein
SH3GLB1 SH3-domain GRB2-like endophilin B1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMIM7 small integral membrane protein 7
SOD2 superoxide dismutase 2, mitochondrial
SPAG9 sperm associated antigen 9
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
SV2C synaptic vesicle glycoprotein 2C
TAC1 tachykinin, precursor 1
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TREM1 triggering receptor expressed on myeloid cells 1
TXNL1 thioredoxin-like 1
TXNL4B thioredoxin-like 4B
UBAP1 ubiquitin associated protein 1
UBB ubiquitin B
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UFD1L ubiquitin fusion degradation 1 like (yeast)
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
USP3 ubiquitin specific peptidase 3
VCAM1 vascular cell adhesion molecule 1
VCP valosin containing protein
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1
WIPI2 WD repeat domain, phosphoinositide interacting 2
YPEL5 yippee-like 5 (Drosophila)
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ADARB1 adenosine deaminase, RNA-specific, B1
ADD3 adducin 3 (gamma)
ADGRE5 adhesion G protein-coupled receptor E5
AKAP12 A kinase (PRKA) anchor protein 12
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C3 aldo-keto reductase family 1, member C3
ANXA4 annexin A4
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASRGL1 asparaginase like 1
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
B3GNT1
BARD1 BRCA1 associated RING domain 1
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C2CD5 C2 calcium-dependent domain containing 5
CA9 carbonic anhydrase IX
CALD1 caldesmon 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CBR4 carbonyl reductase 4
CBX5 chromobox homolog 5
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCND1 cyclin D1
CCNE2 cyclin E2
CCNF cyclin F
CD200 CD200 molecule
CD24 CD24 molecule
CD320 CD320 molecule
CDC25B cell division cycle 25B
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CFH complement factor H
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRDL1 chordin-like 1
CKLF chemokine-like factor
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COLEC12 collectin sub-family member 12
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
CP ceruloplasmin (ferroxidase)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
CXADR coxsackie virus and adenovirus receptor
CYBA cytochrome b-245, alpha polypeptide
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCK deoxycytidine kinase
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DPYD dihydropyrimidine dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
E2F8 E2F transcription factor 8
ELOVL6 ELOVL fatty acid elongase 6
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM64A family with sequence similarity 64, member A
FAT4 FAT atypical cadherin 4
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FOXM1 forkhead box M1
FSTL1 follistatin-like 1
GALE UDP-galactose-4-epimerase
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GAS1 growth arrest-specific 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GSTT1 glutathione S-transferase theta 1
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HADH hydroxyacyl-CoA dehydrogenase
HEG1 heart development protein with EGF-like domains 1
HELLS helicase, lymphoid-specific
HIST3H2A histone cluster 3, H2a
HJURP Holliday junction recognition protein
HMG20B high mobility group 20B
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMGN3 high mobility group nucleosomal binding domain 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNMT histamine N-methyltransferase
HOXC6 homeobox C6
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITGB5 integrin, beta 5
ITM2A integral membrane protein 2A
KANK2 KN motif and ankyrin repeat domains 2
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
LAGE3 L antigen family, member 3
LAMB1 laminin, beta 1
LEPR leptin receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LIG1 ligase I, DNA, ATP-dependent
LIMCH1 LIM and calponin homology domains 1
LMNB1 lamin B1
LMNB2 lamin B2
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUM lumican
LY6E lymphocyte antigen 6 complex, locus E
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKSL1 MARCKS-like 1
MCAM melanoma cell adhesion molecule
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MFAP5 microfibrillar associated protein 5
MKI67 marker of proliferation Ki-67
MMD monocyte to macrophage differentiation-associated
MPHOSPH9 M-phase phosphoprotein 9
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MXRA7 matrix-remodelling associated 7
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYH10 myosin, heavy chain 10, non-muscle
MYLK myosin light chain kinase
NCAPD2 non-SMC condensin I complex, subunit D2
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NMU neuromedin U
NNMT nicotinamide N-methyltransferase
NR2F1 nuclear receptor subfamily 2, group F, member 1
NREP neuronal regeneration related protein
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUP210 nucleoporin 210kDa
NUSAP1 nucleolar and spindle associated protein 1
OXTR oxytocin receptor
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEBP1 phosphatidylethanolamine binding protein 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PLAGL1 pleiomorphic adenoma gene-like 1
PLK1 polo-like kinase 1
PLSCR4 phospholipid scramblase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POSTN periostin, osteoblast specific factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCB protein kinase C, beta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRR7 proline rich 7 (synaptic)
PRSS23 protease, serine, 23
PTGIS prostaglandin I2 (prostacyclin) synthase
PTMA prothymosin, alpha
PTN pleiotrophin
RACGAP1 Rac GTPase activating protein 1
RANBP1 RAN binding protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RHOBTB1 Rho-related BTB domain containing 1
RNASEH2A ribonuclease H2, subunit A
RPIA ribose 5-phosphate isomerase A
RRM2 ribonucleotide reductase M2
S100A4 S100 calcium binding protein A4
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SEPHS1 selenophosphate synthetase 1
SEPT11 septin 11
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SIVA1 SIVA1, apoptosis-inducing factor
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMAD6 SMAD family member 6
SOBP sine oculis binding protein homolog (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
SPON1 spondin 1, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRSF2 serine/arginine-rich splicing factor 2
SRSF6 serine/arginine-rich splicing factor 6
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SULF1 sulfatase 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFDP1 transcription factor Dp-1
TGM2 transglutaminase 2
TK1 thymidine kinase 1, soluble
TMEM106C transmembrane protein 106C
TMEM109 transmembrane protein 109
TMEM14A transmembrane protein 14A
TMEM47 transmembrane protein 47
TMEM5 transmembrane protein 5
TMPO thymopoietin
TMSB15A thymosin beta 15a
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX thymocyte selection-associated high mobility group box
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TRMT5 tRNA methyltransferase 5
TSPAN12 tetraspanin 12
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
USP1 ubiquitin specific peptidase 1
VCAN versican
VRK1 vaccinia related kinase 1
WEE1 WEE1 G2 checkpoint kinase
ZCCHC24 zinc finger, CCHC domain containing 24
ZWINT ZW10 interacting kinetochore protein