BRD-K88510285_B675700.cdx_HCC15_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-K88510285_B675700.cdx_HCC15_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAG3 BCL2-associated athanogene 3
BLVRB biliverdin reductase B
CA4 carbonic anhydrase IV
CD40 CD40 molecule, TNF receptor superfamily member 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRABP2 cellular retinoic acid binding protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF5 eukaryotic translation initiation factor 5
EPN2 epsin 2
EXT1 exostosin glycosyltransferase 1
FOXO1 forkhead box O1
GAGE3 G antigen 3
GBP1 guanylate binding protein 1, interferon-inducible
GPNMB glycoprotein (transmembrane) nmb
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IPO13 importin 13
JCHAIN joining chain of multimeric IgA and IgM
KRT15 keratin 15, type I
KRT23 keratin 23, type I
MMP2 matrix metallopeptidase 2
MZB1 marginal zone B and B1 cell-specific protein
OPTN optineurin
OSER1 oxidative stress responsive serine-rich 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PELI1 pellino E3 ubiquitin protein ligase 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
POU2AF1 POU class 2 associating factor 1
PTPRO protein tyrosine phosphatase, receptor type, O
RGS2 regulator of G-protein signaling 2
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SOD2 superoxide dismutase 2, mitochondrial
SST somatostatin
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TXNL4B thioredoxin-like 4B
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACTA2 actin, alpha 2, smooth muscle, aorta
AGTR1 angiotensin II receptor, type 1
ANXA5 annexin A5
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
C8ORF4 chromosome 8 open reading frame 4
CPVL carboxypeptidase, vitellogenic-like
CRIP1 cysteine-rich protein 1 (intestinal)
CST3 cystatin C
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
DCLK1 doublecortin-like kinase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
F13A1 coagulation factor XIII, A1 polypeptide
F2R coagulation factor II (thrombin) receptor
FAM46A family with sequence similarity 46, member A
FOLR1 folate receptor 1 (adult)
GDF15 growth differentiation factor 15
GPX1 glutathione peroxidase 1
HES1 hes family bHLH transcription factor 1
HOXA10 homeobox A10
HOXC6 homeobox C6
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP7 insulin-like growth factor binding protein 7
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LIMCH1 LIM and calponin homology domains 1
LOX lysyl oxidase
LY6E lymphocyte antigen 6 complex, locus E
MAP1B microtubule-associated protein 1B
MSX1 msh homeobox 1
MX2 MX dynamin-like GTPase 2
NFIB nuclear factor I/B
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRN1 neuritin 1
PDLIM2 PDZ and LIM domain 2 (mystique)
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PMP22 peripheral myelin protein 22
SFN stratifin
SORBS2 sorbin and SH3 domain containing 2
SORBS3 sorbin and SH3 domain containing 3
SOX4 SRY (sex determining region Y)-box 4
SPATS2L spermatogenesis associated, serine-rich 2-like
SRPX sushi-repeat containing protein, X-linked
TACSTD2 tumor-associated calcium signal transducer 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TYRP1 tyrosinase-related protein 1
VCAN versican