BRD-K88510285_B675700.cdx_HA1E_24.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

418 genes differentially expressed following the BRD-K88510285_B675700.cdx_HA1E_24.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANGPT2 angiopoietin 2
ANKRD11 ankyrin repeat domain 11
AQP1 aquaporin 1 (Colton blood group)
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
BMP2 bone morphogenetic protein 2
C18ORF8 chromosome 18 open reading frame 8
C1ORF56 chromosome 1 open reading frame 56
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C5AR1 complement component 5a receptor 1
CA2 carbonic anhydrase II
CA4 carbonic anhydrase IV
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD14 CD14 molecule
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CD93 CD93 molecule
CDC34 cell division cycle 34
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLU clusterin
CPE carboxypeptidase E
CREB3L2 cAMP responsive element binding protein 3-like 2
CXCL10 chemokine (C-X-C motif) ligand 10
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ELANE elastase, neutrophil expressed
EPAS1 endothelial PAS domain protein 1
FAM129A family with sequence similarity 129, member A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FGG fibrinogen gamma chain
FOXO1 forkhead box O1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAGE3 G antigen 3
GAL galanin/GMAP prepropeptide
GEM GTP binding protein overexpressed in skeletal muscle
GIMAP4 GTPase, IMAP family member 4
GIMAP6 GTPase, IMAP family member 6
GLA galactosidase, alpha
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNGR1 interferon gamma receptor 1
IFRD1 interferon-related developmental regulator 1
IGF2R insulin-like growth factor 2 receptor
IGKV1-5 immunoglobulin kappa variable 1-5
INSR insulin receptor
IPO13 importin 13
JAG1 jagged 1
KCMF1 potassium channel modulatory factor 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD12 potassium channel tetramerization domain containing 12
KIAA0226L KIAA0226-like
KLHDC10 kelch domain containing 10
LAPTM5 lysosomal protein transmembrane 5
LCK LCK proto-oncogene, Src family tyrosine kinase
LGALS8 lectin, galactoside-binding, soluble, 8
LPAR6 lysophosphatidic acid receptor 6
LRMP lymphoid-restricted membrane protein
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MMP9 matrix metallopeptidase 9
MNDA myeloid cell nuclear differentiation antigen
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
NCF2 neutrophil cytosolic factor 2
NELL2 NEL-like 2 (chicken)
NGRN neugrin, neurite outgrowth associated
NPC1 Niemann-Pick disease, type C1
NR1H2 nuclear receptor subfamily 1, group H, member 2
ORC1 origin recognition complex, subunit 1
OSBPL1A oxysterol binding protein-like 1A
PARM1 prostate androgen-regulated mucin-like protein 1
PELI1 pellino E3 ubiquitin protein ligase 1
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLVAP plasmalemma vesicle associated protein
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKD2 protein kinase D2
PRRC2C proline-rich coiled-coil 2C
PRTN3 proteinase 3
PTK2 protein tyrosine kinase 2
RANBP2 RAN binding protein 2
RB1CC1 RB1-inducible coiled-coil 1
RBP4 retinol binding protein 4, plasma
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF19B ring finger protein 19B
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SH3GLB1 SH3-domain GRB2-like endophilin B1
SHB Src homology 2 domain containing adaptor protein B
SIRPA signal-regulatory protein alpha
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SNX13 sorting nexin 13
SPARCL1 SPARC-like 1 (hevin)
SQSTM1 sequestosome 1
STX3 syntaxin 3
THBD thrombomodulin
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TREM2 triggering receptor expressed on myeloid cells 2
TRIB3 tribbles pseudokinase 3
TRIM36 tripartite motif containing 36
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
TYROBP TYRO protein tyrosine kinase binding protein
UBXN4 UBX domain protein 4
VSIG4 V-set and immunoglobulin domain containing 4
VWF von Willebrand factor
XIST X inactive specific transcript (non-protein coding)
ZBTB16 zinc finger and BTB domain containing 16
ZC3H15 zinc finger CCCH-type containing 15
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACSF2 acyl-CoA synthetase family member 2
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGA aspartylglucosaminidase
AK4 adenylate kinase 4
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANXA6 annexin A6
ARL3 ADP-ribosylation factor-like 3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATPIF1 ATPase inhibitory factor 1
AURKA aurora kinase A
B3GNT1
BASP1 brain abundant, membrane attached signal protein 1
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BST2 bone marrow stromal cell antigen 2
C21ORF33 chromosome 21 open reading frame 33
C5ORF15 chromosome 5 open reading frame 15
C6ORF48 chromosome 6 open reading frame 48
C6ORF62 chromosome 6 open reading frame 62
CCDC53 coiled-coil domain containing 53
CCDC85B coiled-coil domain containing 85B
CCDC92 coiled-coil domain containing 92
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CCNG1 cyclin G1
CD59 CD59 molecule, complement regulatory protein
CDCA3 cell division cycle associated 3
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CELF2 CUGBP, Elav-like family member 2
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CETN3 centrin, EF-hand protein, 3
CHEK2 checkpoint kinase 2
CHMP4A charged multivesicular body protein 4A
CHMP6 charged multivesicular body protein 6
CIRBP cold inducible RNA binding protein
CLIC3 chloride intracellular channel 3
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
COA3 cytochrome c oxidase assembly factor 3
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
COMP cartilage oligomeric matrix protein
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP2 cysteine-rich protein 2
CTSC cathepsin C
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5A cytochrome b5 type A (microsomal)
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCXR dicarbonyl/L-xylulose reductase
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDT D-dopachrome tautomerase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DERA deoxyribose-phosphate aldolase (putative)
DICER1 dicer 1, ribonuclease type III
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMTF1 cyclin D binding myb-like transcription factor 1
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DYNLRB1 dynein, light chain, roadblock-type 1
EBP emopamil binding protein (sterol isomerase)
ECI2 enoyl-CoA delta isomerase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
ENO3 enolase 3 (beta, muscle)
ENOSF1 enolase superfamily member 1
EPHB2 EPH receptor B2
ERLIN1 ER lipid raft associated 1
ERLIN2 ER lipid raft associated 2
FAM162A family with sequence similarity 162, member A
FAM216A family with sequence similarity 216, member A
FAM57A family with sequence similarity 57, member A
FBN1 fibrillin 1
FKBP3 FK506 binding protein 3, 25kDa
FN1 fibronectin 1
FST follistatin
FSTL1 follistatin-like 1
FUCA1 fucosidase, alpha-L- 1, tissue
FZD7 frizzled class receptor 7
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAA glucosidase, alpha; acid
GALE UDP-galactose-4-epimerase
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLIPR1 GLI pathogenesis-related 1
GOLGA8A golgin A8 family, member A
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GSS glutathione synthetase
GSTA4 glutathione S-transferase alpha 4
GSTM3 glutathione S-transferase mu 3 (brain)
GTF2H5 general transcription factor IIH, polypeptide 5
GTPBP8 GTP-binding protein 8 (putative)
H1FX H1 histone family, member X
HACD1 3-hydroxyacyl-CoA dehydratase 1
HAUS4 HAUS augmin-like complex, subunit 4
HIST1H2BH histone cluster 1, H2bh
HIST1H4C histone cluster 1, H4c
HIST1H4J histone cluster 1, H4j
HIST3H2A histone cluster 3, H2a
HMGN3 high mobility group nucleosomal binding domain 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXC6 homeobox C6
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
ICMT isoprenylcysteine carboxyl methyltransferase
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFRD2 interferon-related developmental regulator 2
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP6 insulin-like growth factor binding protein 6
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KIF20A kinesin family member 20A
KLC1 kinesin light chain 1
KRT10 keratin 10, type I
LAGE3 L antigen family, member 3
LAMC1 laminin, gamma 1 (formerly LAMB2)
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIPA lipase A, lysosomal acid, cholesterol esterase
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LOXL2 lysyl oxidase-like 2
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUM lumican
MAB21L2 mab-21-like 2 (C. elegans)
MARCKSL1 MARCKS-like 1
MET MET proto-oncogene, receptor tyrosine kinase
METRN meteorin, glial cell differentiation regulator
MGST2 microsomal glutathione S-transferase 2
MOK MOK protein kinase
MSRB2 methionine sulfoxide reductase B2
MXRA7 matrix-remodelling associated 7
MXRA8 matrix-remodelling associated 8
MYH10 myosin, heavy chain 10, non-muscle
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
MYLK myosin light chain kinase
MYOF myoferlin
NDN necdin, melanoma antigen (MAGE) family member
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NIT2 nitrilase family, member 2
NNMT nicotinamide N-methyltransferase
NPR3 natriuretic peptide receptor 3
NPY neuropeptide Y
NREP neuronal regeneration related protein
NTM neurotrimin
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUDCD3 NudC domain containing 3
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
PAX8 paired box 8
PCYOX1L prenylcysteine oxidase 1 like
PDGFC platelet derived growth factor C
PDLIM2 PDZ and LIM domain 2 (mystique)
PEBP1 phosphatidylethanolamine binding protein 1
PENK proenkephalin
PFKL phosphofructokinase, liver
PGLS 6-phosphogluconolactonase
PGM1 phosphoglucomutase 1
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein
PLK1 polo-like kinase 1
PNMA2 paraneoplastic Ma antigen 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRDX4 peroxiredoxin 4
PRSS23 protease, serine, 23
PSPH phosphoserine phosphatase
PTCH1 patched 1
PTGES prostaglandin E synthase
PTTG1 pituitary tumor-transforming 1
PXDN peroxidasin
PXMP2 peroxisomal membrane protein 2, 22kDa
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBP1 retinol binding protein 1, cellular
RPA3 replication protein A3, 14kDa
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
RPS27L ribosomal protein S27-like
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGA Ras-related GTP binding A
S100A2 S100 calcium binding protein A2
SCAND1 SCAN domain containing 1
SCP2 sterol carrier protein 2
SEPHS1 selenophosphate synthetase 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC16A4 solute carrier family 16, member 4
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMAD2 SMAD family member 2
SORD sorbitol dehydrogenase
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae)
SPRR1A small proline-rich protein 1A
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
THYN1 thymocyte nuclear protein 1
TMEM106B transmembrane protein 106B
TMEM134 transmembrane protein 134
TMEM14A transmembrane protein 14A
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TMEM50A transmembrane protein 50A
TNC tenascin C
TNIP1 TNFAIP3 interacting protein 1
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
TRAM2 translocation associated membrane protein 2
TRIM8 tripartite motif containing 8
TRMT5 tRNA methyltransferase 5
TSPAN4 tetraspanin 4
TSPAN8 tetraspanin 8
TST thiosulfate sulfurtransferase (rhodanese)
TUBB tubulin, beta class I
TUSC3 tumor suppressor candidate 3
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE3B ubiquitin protein ligase E3B
UGCG UDP-glucose ceramide glucosyltransferase
UROS uroporphyrinogen III synthase
VKORC1 vitamin K epoxide reductase complex, subunit 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZCCHC24 zinc finger, CCHC domain containing 24
ZMAT3 zinc finger, matrin-type 3