BRD-K88510285_B675700.cdx_DV90_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K88510285_B675700.cdx_DV90_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADGRG2 adhesion G protein-coupled receptor G2
ANXA1 annexin A1
ARG2 arginase 2
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX3 armadillo repeat containing, X-linked 3
ARMCX6 armadillo repeat containing, X-linked 6
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL6A3 collagen, type VI, alpha 3
CSTA cystatin A (stefin A)
DMXL1 Dmx-like 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPP4 dipeptidyl-peptidase 4
EDNRB endothelin receptor type B
FOLR1 folate receptor 1 (adult)
GLRX glutaredoxin (thioltransferase)
GREB1 growth regulation by estrogen in breast cancer 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KLF4 Kruppel-like factor 4 (gut)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEF2C myocyte enhancer factor 2C
MFAP3L microfibrillar-associated protein 3-like
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MPO myeloperoxidase
MSMB microseminoprotein, beta-
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NKX3-1 NK3 homeobox 1
NQO2 NAD(P)H dehydrogenase, quinone 2
PEG3 paternally expressed 3
PIR pirin (iron-binding nuclear protein)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRPF4B pre-mRNA processing factor 4B
PSAP prosaposin
PTPRM protein tyrosine phosphatase, receptor type, M
RGS1 regulator of G-protein signaling 1
SCGB2A1 secretoglobin, family 2A, member 1
SGK1 serum/glucocorticoid regulated kinase 1
TBPL1 TBP-like 1
TBX3 T-box 3
TENM1 teneurin transmembrane protein 1
TFPI2 tissue factor pathway inhibitor 2
TMEM47 transmembrane protein 47
TMSB15A thymosin beta 15a
TUBB2A tubulin, beta 2A class IIa
WARS tryptophanyl-tRNA synthetase
WASL Wiskott-Aldrich syndrome-like

decreased expression

Symbol Name
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
AMPD3 adenosine monophosphate deaminase 3
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
B3GNT1
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFB complement factor B
CPA3 carboxypeptidase A3 (mast cell)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
DHCR24 24-dehydrocholesterol reductase
EPHB2 EPH receptor B2
ERBB2 erb-b2 receptor tyrosine kinase 2
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM57A family with sequence similarity 57, member A
FGB fibrinogen beta chain
FTO fat mass and obesity associated
GLUL glutamate-ammonia ligase
GPRC5A G protein-coupled receptor, class C, group 5, member A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGHD immunoglobulin heavy constant delta
IGL immunoglobulin lambda locus
IL32 interleukin 32
IPO13 importin 13
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MFSD10 major facilitator superfamily domain containing 10
MMD monocyte to macrophage differentiation-associated
MMP7 matrix metallopeptidase 7
MT1E metallothionein 1E
MYB v-myb avian myeloblastosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PDZK1IP1 PDZK1 interacting protein 1
PI3 peptidase inhibitor 3, skin-derived
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PON2 paraoxonase 2
PRSS3 protease, serine, 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF43 ring finger protein 43
S100A9 S100 calcium binding protein A9
SCARB1 scavenger receptor class B, member 1
SEPP1 selenoprotein P, plasma, 1
SIRT3 sirtuin 3
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
TMEM45A transmembrane protein 45A
TNS3 tensin 3
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
ZFP36L2 ZFP36 ring finger protein-like 2