BRD-K88510285_B675700.cdx_COV644_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

209 genes differentially expressed following the BRD-K88510285_B675700.cdx_COV644_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA1 acetyl-CoA acyltransferase 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CCNB1 cyclin B1
CD163 CD163 molecule
CD4 CD4 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHEK1 checkpoint kinase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL11A1 collagen, type XI, alpha 1
COL2A1 collagen, type II, alpha 1
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNM3 dynamin 3
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FBN2 fibrillin 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
FRS2 fibroblast growth factor receptor substrate 2
GADD45B growth arrest and DNA-damage-inducible, beta
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB10 growth factor receptor-bound protein 10
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFI44 interferon-induced protein 44
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL1R2 interleukin 1 receptor, type II
INHBA inhibin, beta A
INSM1 insulinoma-associated 1
JUN jun proto-oncogene
KIF14 kinesin family member 14
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LYPD1 LY6/PLAUR domain containing 1
MCL1 myeloid cell leukemia 1
MEG3 maternally expressed 3 (non-protein coding)
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOXD1 monooxygenase, DBH-like 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1X metallothionein 1X
MT2A metallothionein 2A
MYBPC1 myosin binding protein C, slow type
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PBK PDZ binding kinase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCP4 Purkinje cell protein 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POPDC3 popeye domain containing 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RRBP1 ribosome binding protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SRGN serglycin
SST somatostatin
STK10 serine/threonine kinase 10
TCP1 t-complex 1
THBS1 thrombospondin 1
TICAM1 toll-like receptor adaptor molecule 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIM36 tripartite motif containing 36
TSC22D3 TSC22 domain family, member 3
TWIST1 twist family bHLH transcription factor 1

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
AFP alpha-fetoprotein
AKAP1 A kinase (PRKA) anchor protein 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPH aspartate beta-hydroxylase
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
CA12 carbonic anhydrase XII
CAV1 caveolin 1, caveolae protein, 22kDa
CCNG2 cyclin G2
CD200 CD200 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CIRBP cold inducible RNA binding protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKAP4 cytoskeleton-associated protein 4
CKB creatine kinase, brain
COG2 component of oligomeric golgi complex 2
CPA3 carboxypeptidase A3 (mast cell)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRIP1 cysteine-rich protein 1 (intestinal)
CST3 cystatin C
CTSO cathepsin O
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYBA cytochrome b-245, alpha polypeptide
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNALI1 dynein, axonemal, light intermediate chain 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPS8 epidermal growth factor receptor pathway substrate 8
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FRY furry homolog (Drosophila)
FUCA1 fucosidase, alpha-L- 1, tissue
FXYD2 FXYD domain containing ion transport regulator 2
FZD7 frizzled class receptor 7
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPX3 glutathione peroxidase 3
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HIST1H4C histone cluster 1, H4c
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
ITM2A integral membrane protein 2A
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT15 keratin 15, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LBH limb bud and heart development
LBR lamin B receptor
LEPROT leptin receptor overlapping transcript
LGALS3 lectin, galactoside-binding, soluble, 3
LMO2 LIM domain only 2 (rhombotin-like 1)
LTBP3 latent transforming growth factor beta binding protein 3
LYPLA1 lysophospholipase I
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA3 melanoma antigen family A3
MDK midkine (neurite growth-promoting factor 2)
METTL7A methyltransferase like 7A
MTSS1 metastasis suppressor 1
MYLIP myosin regulatory light chain interacting protein
MYO6 myosin VI
NDRG2 NDRG family member 2
NID1 nidogen 1
NME3 NME/NM23 nucleoside diphosphate kinase 3
NPC2 Niemann-Pick disease, type C2
NREP neuronal regeneration related protein
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PLA2G16 phospholipase A2, group XVI
PPAP2B phosphatidic acid phosphatase type 2B
PPAP2C phosphatidic acid phosphatase type 2C
PPARG peroxisome proliferator-activated receptor gamma
PRAME preferentially expressed antigen in melanoma
RBM47 RNA binding motif protein 47
REEP5 receptor accessory protein 5
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPS4Y1 ribosomal protein S4, Y-linked 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SFRP1 secreted frizzled-related protein 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SMAD1 SMAD family member 1
SPON2 spondin 2, extracellular matrix protein
SRRM2 serine/arginine repetitive matrix 2
STOM stomatin
STS steroid sulfatase (microsomal), isozyme S
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBL1X transducin (beta)-like 1X-linked
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCTN1 tectonic family member 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TLE2 transducin-like enhancer of split 2
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMEM47 transmembrane protein 47
TOR3A torsin family 3, member A
TPM1 tropomyosin 1 (alpha)
TUBA1A tubulin, alpha 1a
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VCAN versican
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WFDC2 WAP four-disulfide core domain 2
ZBTB38 zinc finger and BTB domain containing 38