BRD-K88510285_B675700.cdx_CL34_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

185 genes differentially expressed following the BRD-K88510285_B675700.cdx_CL34_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACSL3 acyl-CoA synthetase long-chain family member 3
ADGRG2 adhesion G protein-coupled receptor G2
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
C1S complement component 1, s subcomponent
C3 complement component 3
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC2B C-type lectin domain family 2, member B
CLIC4 chloride intracellular channel 4
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL15A1 collagen, type XV, alpha 1
COL6A2 collagen, type VI, alpha 2
CPM carboxypeptidase M
CSTA cystatin A (stefin A)
CTH cystathionine gamma-lyase
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EPAS1 endothelial PAS domain protein 1
EPRS glutamyl-prolyl-tRNA synthetase
F3 coagulation factor III (thromboplastin, tissue factor)
FASTKD5 FAST kinase domains 5
FGG fibrinogen gamma chain
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GATA3 GATA binding protein 3
GCLM glutamate-cysteine ligase, modifier subunit
GNAS GNAS complex locus
GPC1 glypican 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
JUN jun proto-oncogene
KRT15 keratin 15, type I
KRT18 keratin 18, type I
KRT5 keratin 5, type II
KRT7 keratin 7, type II
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGP matrix Gla protein
MSMB microseminoprotein, beta-
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYOF myoferlin
NBL1 neuroblastoma 1, DAN family BMP antagonist
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OSER1 oxidative stress responsive serine-rich 1
PEG10 paternally expressed 10
PEX11A peroxisomal biogenesis factor 11 alpha
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLA2G16 phospholipase A2, group XVI
PLIN2 perilipin 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PTP4A1 protein tyrosine phosphatase type IVA, member 1
REEP1 receptor accessory protein 1
RGCC regulator of cell cycle
RHOB ras homolog family member B
RTN1 reticulon 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SORBS2 sorbin and SH3 domain containing 2
STC2 stanniocalcin 2
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMSB15A thymosin beta 15a
TP53BP2 tumor protein p53 binding protein 2
TPD52L1 tumor protein D52-like 1
TRIB1 tribbles pseudokinase 1
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ASCL1 achaete-scute family bHLH transcription factor 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B3GNT1
BMP4 bone morphogenetic protein 4
BPHL biphenyl hydrolase-like (serine hydrolase)
C8ORF4 chromosome 8 open reading frame 4
CANT1 calcium activated nucleotidase 1
CCNB1 cyclin B1
CCND2 cyclin D2
CDC25B cell division cycle 25B
CDH17 cadherin 17, LI cadherin (liver-intestine)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COPS7A COP9 signalosome subunit 7A
DUSP6 dual specificity phosphatase 6
ECI2 enoyl-CoA delta isomerase 2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FABP1 fatty acid binding protein 1, liver
FAM57A family with sequence similarity 57, member A
FERMT1 fermitin family member 1
FXYD2 FXYD domain containing ion transport regulator 2
GMDS GDP-mannose 4,6-dehydratase
GPM6A glycoprotein M6A
GPX2 glutathione peroxidase 2
GTF3A general transcription factor IIIA
HAL histidine ammonia-lyase
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFITM1 interferon induced transmembrane protein 1
IGHM immunoglobulin heavy constant mu
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KCTD12 potassium channel tetramerization domain containing 12
LRP4 low density lipoprotein receptor-related protein 4
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEBL nebulette
NREP neuronal regeneration related protein
NRN1 neuritin 1
PCCB propionyl CoA carboxylase, beta polypeptide
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PF4 platelet factor 4
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PRR7 proline rich 7 (synaptic)
PRUNE2 prune homolog 2 (Drosophila)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPIA ribose 5-phosphate isomerase A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SATB2 SATB homeobox 2
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPON1 spondin 1, extracellular matrix protein
TFF3 trefoil factor 3 (intestinal)
TGFBR3 transforming growth factor, beta receptor III
TMEM2 transmembrane protein 2
TOX3 TOX high mobility group box family member 3
TSPAN3 tetraspanin 3
TSPAN8 tetraspanin 8
TYRP1 tyrosinase-related protein 1
VIM vimentin