BRD-K88510285_B675700.cdx_AGS_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

202 genes differentially expressed following the BRD-K88510285_B675700.cdx_AGS_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANKRD11 ankyrin repeat domain 11
ANO1 anoctamin 1, calcium activated chloride channel
ARG2 arginase 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
AZU1 azurocidin 1
BAG3 BCL2-associated athanogene 3
BEX4 brain expressed, X-linked 4
BMP4 bone morphogenetic protein 4
BSDC1 BSD domain containing 1
CA2 carbonic anhydrase II
CALB1 calbindin 1, 28kDa
CD40 CD40 molecule, TNF receptor superfamily member 5
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COTL1 coactosin-like F-actin binding protein 1
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CSRP2 cysteine and glycine-rich protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FOXF2 forkhead box F2
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GPR137B G protein-coupled receptor 137B
GRB10 growth factor receptor-bound protein 10
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HBP1 HMG-box transcription factor 1
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD1 interferon-related developmental regulator 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JUN jun proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KIAA1462 KIAA1462
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LGALS8 lectin, galactoside-binding, soluble, 8
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MDK midkine (neurite growth-promoting factor 2)
MFSD10 major facilitator superfamily domain containing 10
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NOTCH1 notch 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLCL1 phospholipase C-like 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAP prosaposin
PSD3 pleckstrin and Sec7 domain containing 3
QKI QKI, KH domain containing, RNA binding
RGCC regulator of cell cycle
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN1 reticulon 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SFRP4 secreted frizzled-related protein 4
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS1 thrombospondin 1
TLE4 transducin-like enhancer of split 4
TMSB15A thymosin beta 15a
TPD52L1 tumor protein D52-like 1
TRIM36 tripartite motif containing 36
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UFD1L ubiquitin fusion degradation 1 like (yeast)
ZEB2 zinc finger E-box binding homeobox 2
ZFPM2 zinc finger protein, FOG family member 2
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
AHNAK2 AHNAK nucleoprotein 2
AMD1 adenosylmethionine decarboxylase 1
ANXA6 annexin A6
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
AURKA aurora kinase A
B3GNT1
BAG2 BCL2-associated athanogene 2
BTN3A2 butyrophilin, subfamily 3, member A2
C1S complement component 1, s subcomponent
C3 complement component 3
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPA centromere protein A
CHI3L2 chitinase 3-like 2
COX11 COX11 cytochrome c oxidase copper chaperone
CTSC cathepsin C
CXCL14 chemokine (C-X-C motif) ligand 14
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FABP7 fatty acid binding protein 7, brain
GBP2 guanylate binding protein 2, interferon-inducible
HDAC9 histone deacetylase 9
HIST1H2BK histone cluster 1, H2bk
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGHM immunoglobulin heavy constant mu
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KIAA0125 KIAA0125
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT1 keratin 1, type II
KRT23 keratin 23, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRP10 low density lipoprotein receptor-related protein 10
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MARCKS myristoylated alanine-rich protein kinase C substrate
MRPL57 mitochondrial ribosomal protein L57
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NGRN neugrin, neurite outgrowth associated
NME1 NME/NM23 nucleoside diphosphate kinase 1
NNMT nicotinamide N-methyltransferase
NOP16 NOP16 nucleolar protein
PA2G4 proliferation-associated 2G4, 38kDa
PAX5 paired box 5
PEBP1 phosphatidylethanolamine binding protein 1
PI3 peptidase inhibitor 3, skin-derived
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PPA1 pyrophosphatase (inorganic) 1
PRDX2 peroxiredoxin 2
PRDX4 peroxiredoxin 4
PRSS23 protease, serine, 23
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RBPMS RNA binding protein with multiple splicing
RPIA ribose 5-phosphate isomerase A
RPL31 ribosomal protein L31
RPL36 ribosomal protein L36
RPS26 ribosomal protein S26
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SATB2 SATB homeobox 2
SCEL sciellin
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
TARBP1 TAR (HIV-1) RNA binding protein 1
TJP2 tight junction protein 2
TM4SF1 transmembrane 4 L six family member 1
TMEM147 transmembrane protein 147
TNC tenascin C
UPK1B uroplakin 1B
WDR12 WD repeat domain 12