BRD-K88510285_B675700.cdx_A673_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K88510285_B675700.cdx_A673_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BIRC2 baculoviral IAP repeat containing 2
BTG3 BTG family, member 3
CD24 CD24 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLC Charcot-Leyden crystal galectin
CLDN10 claudin 10
CSNK1A1 casein kinase 1, alpha 1
CTH cystathionine gamma-lyase
CTSH cathepsin H
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EHF ets homologous factor
EIF5 eukaryotic translation initiation factor 5
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPRS glutamyl-prolyl-tRNA synthetase
ERBB3 erb-b2 receptor tyrosine kinase 3
FMO1 flavin containing monooxygenase 1
FOSL1 FOS-like antigen 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD1 interferon-related developmental regulator 1
IGKV4-1 immunoglobulin kappa variable 4-1
ITFG1 integrin alpha FG-GAP repeat containing 1
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KRT15 keratin 15, type I
LCN2 lipocalin 2
LSG1 large 60S subunit nuclear export GTPase 1
LTF lactotransferrin
MBNL2 muscleblind-like splicing regulator 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MUC4 mucin 4, cell surface associated
NFE2L2 nuclear factor, erythroid 2-like 2
OSER1 oxidative stress responsive serine-rich 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDZK1IP1 PDZK1 interacting protein 1
PIR pirin (iron-binding nuclear protein)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAP prosaposin
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SIK1 salt-inducible kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQSTM1 sequestosome 1
THBS1 thrombospondin 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
ZBTB38 zinc finger and BTB domain containing 38

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
APOLD1 apolipoprotein L domain containing 1
B3GNT1
BCHE butyrylcholinesterase
CA12 carbonic anhydrase XII
CCDC85B coiled-coil domain containing 85B
CCNF cyclin F
CD44 CD44 molecule (Indian blood group)
CRIP2 cysteine-rich protein 2
CSRP2 cysteine and glycine-rich protein 2
DDAH1 dimethylarginine dimethylaminohydrolase 1
DUSP6 dual specificity phosphatase 6
ELOVL6 ELOVL fatty acid elongase 6
FRY furry homolog (Drosophila)
FST follistatin
GPM6A glycoprotein M6A
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI6 interferon, alpha-inducible protein 6
IL1RN interleukin 1 receptor antagonist
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IPO13 importin 13
LMO3 LIM domain only 3 (rhombotin-like 2)
METTL7A methyltransferase like 7A
NR2F6 nuclear receptor subfamily 2, group F, member 6
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDLIM3 PDZ and LIM domain 3
PLN phospholamban
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSRC1 proline/serine-rich coiled-coil 1
RERE arginine-glutamic acid dipeptide (RE) repeats
SCAND1 SCAN domain containing 1
SOBP sine oculis binding protein homolog (Drosophila)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX2 SRY (sex determining region Y)-box 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SYNM synemin, intermediate filament protein
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TNS1 tensin 1
WWTR1 WW domain containing transcription regulator 1