BRD-K88510285_B675700.cdx_A549_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

200 genes differentially expressed following the BRD-K88510285_B675700.cdx_A549_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACBD3 acyl-CoA binding domain containing 3
AIM2 absent in melanoma 2
AKAP8L A kinase (PRKA) anchor protein 8-like
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BAG3 BCL2-associated athanogene 3
BIRC2 baculoviral IAP repeat containing 2
BTG3 BTG family, member 3
CACYBP calcyclin binding protein
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLDN10 claudin 10
CLU clusterin
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5R1 cytochrome b5 reductase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP2 dual specificity phosphatase 2
EAF2 ELL associated factor 2
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
FHL2 four and a half LIM domains 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GRB10 growth factor receptor-bound protein 10
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IDO1 indoleamine 2,3-dioxygenase 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
INHBA inhibin, beta A
ISLR immunoglobulin superfamily containing leucine-rich repeat
ITM2A integral membrane protein 2A
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KCMF1 potassium channel modulatory factor 1
LGALS8 lectin, galactoside-binding, soluble, 8
MFAP3L microfibrillar-associated protein 3-like
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NANS N-acetylneuraminic acid synthase
NFE2L1 nuclear factor, erythroid 2-like 1
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PELI1 pellino E3 ubiquitin protein ligase 1
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POU2AF1 POU class 2 associating factor 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS1 regulator of G-protein signaling 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX11 sorting nexin 11
SOCS1 suppressor of cytokine signaling 1
SOD1 superoxide dismutase 1, soluble
STK38L serine/threonine kinase 38 like
STXBP6 syntaxin binding protein 6 (amisyn)
TARS threonyl-tRNA synthetase
TES testin LIM domain protein
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLK2 tousled-like kinase 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNL4B thioredoxin-like 4B
UFD1L ubiquitin fusion degradation 1 like (yeast)
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACTG2 actin, gamma 2, smooth muscle, enteric
AGTR1 angiotensin II receptor, type 1
AHNAK2 AHNAK nucleoprotein 2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDOB aldolase B, fructose-bisphosphate
AOX1 aldehyde oxidase 1
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ASCL1 achaete-scute family bHLH transcription factor 1
ASPH aspartate beta-hydroxylase
BMI1 BMI1 proto-oncogene, polycomb ring finger
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC85B coiled-coil domain containing 85B
CCND1 cyclin D1
CCNF cyclin F
CD24 CD24 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CES2 carboxylesterase 2
CFI complement factor I
CHGB chromogranin B
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL4A6 collagen, type IV, alpha 6
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DACH1 dachshund family transcription factor 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELOVL6 ELOVL fatty acid elongase 6
EPN2 epsin 2
EREG epiregulin
FST follistatin
G0S2 G0/G1 switch 2
GBP2 guanylate binding protein 2, interferon-inducible
GPSM2 G-protein signaling modulator 2
GPX3 glutathione peroxidase 3
HMGB1 high mobility group box 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IL1RN interleukin 1 receptor antagonist
IPO7 importin 7
IRS1 insulin receptor substrate 1
ITGA6 integrin, alpha 6
KYNU kynureninase
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MYD88 myeloid differentiation primary response 88
MYH11 myosin, heavy chain 11, smooth muscle
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NR2F1 nuclear receptor subfamily 2, group F, member 1
NRN1 neuritin 1
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
OPN3 opsin 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCDH9 protocadherin 9
PLN phospholamban
PNMA2 paraneoplastic Ma antigen 2
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRSS23 protease, serine, 23
PSRC1 proline/serine-rich coiled-coil 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RHOBTB3 Rho-related BTB domain containing 3
RIN2 Ras and Rab interactor 2
RNF167 ring finger protein 167
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SFN stratifin
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THSD7A thrombospondin, type I, domain containing 7A
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TP53I3 tumor protein p53 inducible protein 3
VCAN versican