BRD-K88510285_B675700.cdx_A375_6.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K88510285_B675700.cdx_A375_6.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BTG3 BTG family, member 3
C9ORF91 chromosome 9 open reading frame 91
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CRABP2 cellular retinoic acid binding protein 2
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EIF5 eukaryotic translation initiation factor 5
EPRS glutamyl-prolyl-tRNA synthetase
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAS Fas cell surface death receptor
GARS glycyl-tRNA synthetase
GUSBP11 glucuronidase, beta pseudogene 11
HIRA histone cell cycle regulator
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
JUN jun proto-oncogene
LGALS8 lectin, galactoside-binding, soluble, 8
LTB lymphotoxin beta (TNF superfamily, member 3)
MAOA monoamine oxidase A
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
OSER1 oxidative stress responsive serine-rich 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRGN serglycin
TARS threonyl-tRNA synthetase
TRIB3 tribbles pseudokinase 3
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
UBB ubiquitin B
UBE3C ubiquitin protein ligase E3C
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRE5 adhesion G protein-coupled receptor E5
ALCAM activated leukocyte cell adhesion molecule
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
AURKA aurora kinase A
CCND1 cyclin D1
CCNF cyclin F
CD9 CD9 molecule
CRIP2 cysteine-rich protein 2
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DARS aspartyl-tRNA synthetase
DKK1 dickkopf WNT signaling pathway inhibitor 1
EDNRB endothelin receptor type B
ERBB3 erb-b2 receptor tyrosine kinase 3
FOXD1 forkhead box D1
FZD7 frizzled class receptor 7
GPX3 glutathione peroxidase 3
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
ITGA6 integrin, alpha 6
JADE2 jade family PHD finger 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MFAP5 microfibrillar associated protein 5
MIA melanoma inhibitory activity
MOK MOK protein kinase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NDN necdin, melanoma antigen (MAGE) family member
NT5E 5'-nucleotidase, ecto (CD73)
NTM neurotrimin
PHLDA1 pleckstrin homology-like domain, family A, member 1
PNMA2 paraneoplastic Ma antigen 2
PRSS23 protease, serine, 23
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMAD3 SMAD family member 3
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNS3 tensin 3
TPM1 tropomyosin 1 (alpha)
ZCCHC24 zinc finger, CCHC domain containing 24