BRD-K88510285_B675700.cdx_A375_24.0_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

416 genes differentially expressed following the BRD-K88510285_B675700.cdx_A375_24.0_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALAS1 5'-aminolevulinate synthase 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AQP1 aquaporin 1 (Colton blood group)
ARL4C ADP-ribosylation factor-like 4C
ARMCX1 armadillo repeat containing, X-linked 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
BLVRB biliverdin reductase B
BRD4 bromodomain containing 4
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
C1ORF54 chromosome 1 open reading frame 54
C5AR1 complement component 5a receptor 1
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CD24 CD24 molecule
CD2AP CD2-associated protein
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD86 CD86 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC2 chloride intracellular channel 2
COL8A2 collagen, type VIII, alpha 2
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CTNND1 catenin (cadherin-associated protein), delta 1
CTNS cystinosin, lysosomal cystine transporter
CXCR4 chemokine (C-X-C motif) receptor 4
CYB5R1 cytochrome b5 reductase 1
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DEFA4 defensin, alpha 4, corticostatin
DENND1B DENN/MADD domain containing 1B
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOK5 docking protein 5
DPP4 dipeptidyl-peptidase 4
DSE dermatan sulfate epimerase
DST dystonin
DUSP1 dual specificity phosphatase 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ELF4 E74-like factor 4 (ets domain transcription factor)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EXT1 exostosin glycosyltransferase 1
FAM117A family with sequence similarity 117, member A
FAM129A family with sequence similarity 129, member A
FAM69A family with sequence similarity 69, member A
FGFR1 fibroblast growth factor receptor 1
FHOD3 formin homology 2 domain containing 3
FILIP1L filamin A interacting protein 1-like
FMOD fibromodulin
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAL galanin/GMAP prepropeptide
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GJA1 gap junction protein, alpha 1, 43kDa
GLA galactosidase, alpha
GLRX glutaredoxin (thioltransferase)
GMPR guanosine monophosphate reductase
GRB7 growth factor receptor-bound protein 7
H2AFV H2A histone family, member V
HBB hemoglobin, beta
HBD hemoglobin, delta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNGR1 interferon gamma receptor 1
IFRD1 interferon-related developmental regulator 1
IPO13 importin 13
JAG1 jagged 1
JUN jun proto-oncogene
JUP junction plakoglobin
KCTD12 potassium channel tetramerization domain containing 12
KIAA0226L KIAA0226-like
LARP6 La ribonucleoprotein domain family, member 6
LGALS8 lectin, galactoside-binding, soluble, 8
LPAR6 lysophosphatidic acid receptor 6
LRP10 low density lipoprotein receptor-related protein 10
LRP12 low density lipoprotein receptor-related protein 12
LTB lymphotoxin beta (TNF superfamily, member 3)
LTF lactotransferrin
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2B1 mannosidase, alpha, class 2B, member 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEIS2 Meis homeobox 2
MEST mesoderm specific transcript
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MOSPD1 motile sperm domain containing 1
MPPED2 metallophosphoesterase domain containing 2
MSMB microseminoprotein, beta-
MX1 MX dynamin-like GTPase 1
MYO1D myosin ID
NCF2 neutrophil cytosolic factor 2
NEFH neurofilament, heavy polypeptide
NPC1 Niemann-Pick disease, type C1
NXN nucleoredoxin
ODC1 ornithine decarboxylase 1
OGN osteoglycin
ORC1 origin recognition complex, subunit 1
OSER1 oxidative stress responsive serine-rich 1
PDPN podoplanin
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLEKHO1 pleckstrin homology domain containing, family O member 1
PMM2 phosphomannomutase 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRRC2C proline-rich coiled-coil 2C
PTN pleiotrophin
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP4 secreted frizzled-related protein 4
SHB Src homology 2 domain containing adaptor protein B
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOCS2 suppressor of cytokine signaling 2
SOD2 superoxide dismutase 2, mitochondrial
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
SRGN serglycin
SSPN sarcospan
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TCF4 transcription factor 4
TESK1 testis-specific kinase 1
TLR7 toll-like receptor 7
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TREM2 triggering receptor expressed on myeloid cells 2
TRIB3 tribbles pseudokinase 3
TTC39A tetratricopeptide repeat domain 39A
TUBA4A tubulin, alpha 4a
TXNRD1 thioredoxin reductase 1
UBXN4 UBX domain protein 4
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UFD1L ubiquitin fusion degradation 1 like (yeast)
WBP5 WW domain binding protein 5
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABHD2 abhydrolase domain containing 2
ACAT1 acetyl-CoA acetyltransferase 1
ACOT7 acyl-CoA thioesterase 7
ACP6 acid phosphatase 6, lysophosphatidic
ACTN1 actinin, alpha 1
ADD3 adducin 3 (gamma)
ADGRG6 adhesion G protein-coupled receptor G6
AKAP7 A kinase (PRKA) anchor protein 7
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA6 annexin A6
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOD apolipoprotein D
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
AURKA aurora kinase A
AURKB aurora kinase B
B3GNT1
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB3 BUB3 mitotic checkpoint protein
CALD1 caldesmon 1
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CBR4 carbonyl reductase 4
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CDC25B cell division cycle 25B
CDC42 cell division cycle 42
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDH19 cadherin 19, type 2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CHRDL1 chordin-like 1
CIRBP cold inducible RNA binding protein
CIT citron rho-interacting serine/threonine kinase
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COA3 cytochrome c oxidase assembly factor 3
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL9A3 collagen, type IX, alpha 3
CPNE1 copine I
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP2 cysteine-rich protein 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSRP1 cysteine and glycine-rich protein 1
CST3 cystatin C
CTSC cathepsin C
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYBA cytochrome b-245, alpha polypeptide
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCPS decapping enzyme, scavenger
DCXR dicarbonyl/L-xylulose reductase
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
ECI2 enoyl-CoA delta isomerase 2
EDNRB endothelin receptor type B
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
EPHA3 EPH receptor A3
ERBB3 erb-b2 receptor tyrosine kinase 3
ETFB electron-transfer-flavoprotein, beta polypeptide
ETV1 ets variant 1
F12 coagulation factor XII (Hageman factor)
FAM208A family with sequence similarity 208, member A
FAM216A family with sequence similarity 216, member A
FAM64A family with sequence similarity 64, member A
FSTL1 follistatin-like 1
FZD7 frizzled class receptor 7
GALE UDP-galactose-4-epimerase
GAS7 growth arrest-specific 7
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GPSM2 G-protein signaling modulator 2
GSTM3 glutathione S-transferase mu 3 (brain)
GSTT1 glutathione S-transferase theta 1
GTF2H5 general transcription factor IIH, polypeptide 5
GTSE1 G-2 and S-phase expressed 1
H1F0 H1 histone family, member 0
H2AFX H2A histone family, member X
HADH hydroxyacyl-CoA dehydrogenase
HIST3H2A histone cluster 3, H2a
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLTF helicase-like transcription factor
HMGA2 high mobility group AT-hook 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
ICAM3 intercellular adhesion molecule 3
ICMT isoprenylcysteine carboxyl methyltransferase
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL1RAP interleukin 1 receptor accessory protein
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
JADE2 jade family PHD finger 2
KANK2 KN motif and ankyrin repeat domains 2
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KRT7 keratin 7, type II
LAGE3 L antigen family, member 3
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LGALS1 lectin, galactoside-binding, soluble, 1
LYPLA1 lysophospholipase I
MAGEA1 melanoma antigen family A1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA5 melanoma antigen family A5
MAGEA6 melanoma antigen family A6
MAGEC2 melanoma antigen family C2
MAP2K6 mitogen-activated protein kinase kinase 6
MARCKSL1 MARCKS-like 1
MIA melanoma inhibitory activity
MKI67 marker of proliferation Ki-67
MOK MOK protein kinase
MSRB2 methionine sulfoxide reductase B2
MXRA7 matrix-remodelling associated 7
NBN nibrin
NCBP2 nuclear cap binding protein subunit 2, 20kDa
NDN necdin, melanoma antigen (MAGE) family member
NFIB nuclear factor I/B
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NNMT nicotinamide N-methyltransferase
NNT nicotinamide nucleotide transhydrogenase
NREP neuronal regeneration related protein
NTM neurotrimin
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
OXLD1 oxidoreductase-like domain containing 1
PBK PDZ binding kinase
PCDH9 protocadherin 9
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDLIM2 PDZ and LIM domain 2 (mystique)
PGM1 phosphoglucomutase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
PLP1 proteolipid protein 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRAF2 PRA1 domain family, member 2
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCZ protein kinase C, zeta
PRPF4 pre-mRNA processing factor 4
PRR7 proline rich 7 (synaptic)
PRSS23 protease, serine, 23
PSPH phosphoserine phosphatase
PTTG1 pituitary tumor-transforming 1
PURA purine-rich element binding protein A
PXMP2 peroxisomal membrane protein 2, 22kDa
QDPR quinoid dihydropteridine reductase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBPMS RNA binding protein with multiple splicing
RHOBTB3 Rho-related BTB domain containing 3
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGA Ras-related GTP binding A
S100A10 S100 calcium binding protein A10
S100A4 S100 calcium binding protein A4
S100B S100 calcium binding protein B
SCAND1 SCAN domain containing 1
SELL selectin L
SEPT8 septin 8
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMAD3 SMAD family member 3
SORD sorbitol dehydrogenase
SOX10 SRY (sex determining region Y)-box 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPX sushi-repeat containing protein, X-linked
STMN1 stathmin 1
STOM stomatin
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SYNM synemin, intermediate filament protein
TACC3 transforming, acidic coiled-coil containing protein 3
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TM4SF1 transmembrane 4 L six family member 1
TMEM14A transmembrane protein 14A
TMEM2 transmembrane protein 2
TMEM251 transmembrane protein 251
TMEM47 transmembrane protein 47
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRIOBP TRIO and F-actin binding protein
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
TSPAN4 tetraspanin 4
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UPK1B uroplakin 1B
VCAN versican
XYLT1 xylosyltransferase I
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC24 zinc finger, CCHC domain containing 24