BRD-K88378636_withaferin-a_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

412 genes differentially expressed following the BRD-K88378636_withaferin-a_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALAS2 5'-aminolevulinate synthase 2
ANGPT1 angiopoietin 1
ANKRD11 ankyrin repeat domain 11
AP1G1 adaptor-related protein complex 1, gamma 1 subunit
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AVPI1 arginine vasopressin-induced 1
BAG3 BCL2-associated athanogene 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRD4 bromodomain containing 4
CBS cystathionine-beta-synthase
CD1B CD1b molecule
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHMP2B charged multivesicular body protein 2B
CLTB clathrin, light chain B
CORO1C coronin, actin binding protein, 1C
CRABP1 cellular retinoic acid binding protein 1
CST1 cystatin SN
CTH cystathionine gamma-lyase
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTSL cathepsin L
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTIP cytohesin 1 interacting protein
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DFNA5 deafness, autosomal dominant 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSE dermatan sulfate epimerase
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP3 dual specificity phosphatase 3
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EGF epidermal growth factor
ELL2 elongation factor, RNA polymerase II, 2
EMC3 ER membrane protein complex subunit 3
F13A1 coagulation factor XIII, A1 polypeptide
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
FZD2 frizzled class receptor 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GBAP1 glucosidase, beta, acid pseudogene 1
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GDF15 growth differentiation factor 15
GLIPR1 GLI pathogenesis-related 1
GLRX glutaredoxin (thioltransferase)
GPER1 G protein-coupled estrogen receptor 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GREM1 gremlin 1, DAN family BMP antagonist
GTPBP2 GTP binding protein 2
HBB hemoglobin, beta
HBD hemoglobin, delta
HEPH hephaestin
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD1 interferon-related developmental regulator 1
IL10RA interleukin 10 receptor, alpha
ISG20 interferon stimulated exonuclease gene 20kDa
IST1 increased sodium tolerance 1 homolog (yeast)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KDM3A lysine (K)-specific demethylase 3A
KIF5B kinesin family member 5B
KYNU kynureninase
LDLR low density lipoprotein receptor
LGALS8 lectin, galactoside-binding, soluble, 8
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MBNL2 muscleblind-like splicing regulator 2
MDFIC MyoD family inhibitor domain containing
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MSX2 msh homeobox 2
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
MYO10 myosin X
NCOA3 nuclear receptor coactivator 3
NEU1 sialidase 1 (lysosomal sialidase)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEA15 phosphoprotein enriched in astrocytes 15
PF4 platelet factor 4
PFN2 profilin 2
PHGDH phosphoglycerate dehydrogenase
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
POMP proteasome maturation protein
PPARG peroxisome proliferator-activated receptor gamma
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PTPN12 protein tyrosine phosphatase, non-receptor type 12
QPRT quinolinate phosphoribosyltransferase
RAB3B RAB3B, member RAS oncogene family
RB1CC1 RB1-inducible coiled-coil 1
RBP1 retinol binding protein 1, cellular
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
RIN3 Ras and Rab interactor 3
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SCG5 secretogranin V
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SESN1 sestrin 1
SFTPC surfactant protein C
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNX11 sorting nexin 11
SOWAHC sosondowah ankyrin repeat domain family member C
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TBX3 T-box 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TGIF1 TGFB-induced factor homeobox 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM2 transmembrane protein 2
TMEM41B transmembrane protein 41B
TNPO1 transportin 1
TPBG trophoblast glycoprotein
TSC22D2 TSC22 domain family, member 2
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUBB6 tubulin, beta 6 class V
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
UBXN7 UBX domain protein 7
UFD1L ubiquitin fusion degradation 1 like (yeast)
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WNK1 WNK lysine deficient protein kinase 1
WNT5A wingless-type MMTV integration site family, member 5A
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
ZC3H15 zinc finger CCCH-type containing 15
ZMYM2 zinc finger, MYM-type 2
ZNF292 zinc finger protein 292
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ADIRF adipogenesis regulatory factor
AGRN agrin
AHCY adenosylhomocysteinase
AK2 adenylate kinase 2
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA6 annexin A6
APEH acylaminoacyl-peptide hydrolase
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPN asporin
ASRGL1 asparaginase like 1
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BHLHE41 basic helix-loop-helix family, member e41
BST2 bone marrow stromal cell antigen 2
C1QBP complement component 1, q subcomponent binding protein
C3 complement component 3
C7 complement component 7
CA12 carbonic anhydrase XII
CADPS2 Ca++-dependent secretion activator 2
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CCNA2 cyclin A2
CD24 CD24 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHRDL1 chordin-like 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLU clusterin
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
CORO1A coronin, actin binding protein, 1A
CRIP2 cysteine-rich protein 2
CS citrate synthase
CTBP1 C-terminal binding protein 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
DAPK1 death-associated protein kinase 1
DCK deoxycytidine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DES desmin
DHFR dihydrofolate reductase
DLD dihydrolipoamide dehydrogenase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUT deoxyuridine triphosphatase
EDNRA endothelin receptor type A
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EHF ets homologous factor
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF3K eukaryotic translation initiation factor 3, subunit K
EIF5A eukaryotic translation initiation factor 5A
EML3 echinoderm microtubule associated protein like 3
ERBB3 erb-b2 receptor tyrosine kinase 3
F12 coagulation factor XII (Hageman factor)
FAM3C family with sequence similarity 3, member C
FASN fatty acid synthase
FGFR3 fibroblast growth factor receptor 3
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
FXYD6 FXYD domain containing ion transport regulator 6
GAS1 growth arrest-specific 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPI glucose-6-phosphate isomerase
HADH hydroxyacyl-CoA dehydrogenase
HLF hepatic leukemia factor
HNMT histamine N-methyltransferase
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IFRD2 interferon-related developmental regulator 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IGLL1 immunoglobulin lambda-like polypeptide 1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL32 interleukin 32
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INHBB inhibin, beta B
ISOC2 isochorismatase domain containing 2
ISYNA1 inositol-3-phosphate synthase 1
JADE2 jade family PHD finger 2
JAG1 jagged 1
JAG2 jagged 2
KANK1 KN motif and ankyrin repeat domains 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LAGE3 L antigen family, member 3
LAMB1 laminin, beta 1
LAPTM5 lysosomal protein transmembrane 5
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LIMA1 LIM domain and actin binding 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRPPRC leucine-rich pentatricopeptide repeat containing
LTB lymphotoxin beta (TNF superfamily, member 3)
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MGP matrix Gla protein
MMP9 matrix metallopeptidase 9
MREG melanoregulin
MRPL12 mitochondrial ribosomal protein L12
MRPS12 mitochondrial ribosomal protein S12
MSL1 male-specific lethal 1 homolog (Drosophila)
MTUS1 microtubule associated tumor suppressor 1
MUC16 mucin 16, cell surface associated
MXRA5 matrix-remodelling associated 5
MYB v-myb avian myeloblastosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NEB nebulin
NEFH neurofilament, heavy polypeptide
NELL2 NEL-like 2 (chicken)
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKG7 natural killer cell granule protein 7
NME1 NME/NM23 nucleoside diphosphate kinase 1
NMU neuromedin U
NPDC1 neural proliferation, differentiation and control, 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
OLFM1 olfactomedin 1
OLFM4 olfactomedin 4
OSR2 odd-skipped related transciption factor 2
OXA1L oxidase (cytochrome c) assembly 1-like
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBX1 pre-B-cell leukemia homeobox 1
PCCB propionyl CoA carboxylase, beta polypeptide
PDE4B phosphodiesterase 4B, cAMP-specific
PDHB pyruvate dehydrogenase (lipoamide) beta
PEG10 paternally expressed 10
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PLN phospholamban
PLSCR4 phospholipid scramblase 4
PNMA2 paraneoplastic Ma antigen 2
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POSTN periostin, osteoblast specific factor
POU2AF1 POU class 2 associating factor 1
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PRKCD protein kinase C, delta
PRKCH protein kinase C, eta
PRUNE2 prune homolog 2 (Drosophila)
PSIP1 PC4 and SFRS1 interacting protein 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PXDN peroxidasin
PYCARD PYD and CARD domain containing
QARS glutaminyl-tRNA synthetase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RFC2 replication factor C (activator 1) 2, 40kDa
RGS13 regulator of G-protein signaling 13
RPL22 ribosomal protein L22
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
SCGB2A2 secretoglobin, family 2A, member 2
SERBP1 SERPINE1 mRNA binding protein 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SOD2 superoxide dismutase 2, mitochondrial
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SPDEF SAM pointed domain containing ETS transcription factor
SPON1 spondin 1, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRM spermidine synthase
SRPX sushi-repeat containing protein, X-linked
SRSF6 serine/arginine-rich splicing factor 6
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STMN1 stathmin 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SULF1 sulfatase 1
SYNGR3 synaptogyrin 3
TACSTD2 tumor-associated calcium signal transducer 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TCL1A T-cell leukemia/lymphoma 1A
TFDP1 transcription factor Dp-1
TFPI2 tissue factor pathway inhibitor 2
TGFB3 transforming growth factor, beta 3
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TKT transketolase
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAP1 TNF receptor-associated protein 1
TRIM28 tripartite motif containing 28
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSPAN4 tetraspanin 4
TTC39A tetratricopeptide repeat domain 39A
TYMS thymidylate synthetase
UBE2M ubiquitin-conjugating enzyme E2M
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VTCN1 V-set domain containing T cell activation inhibitor 1
ZEB1 zinc finger E-box binding homeobox 1
ZMIZ1 zinc finger, MIZ-type containing 1
ZWINT ZW10 interacting kinetochore protein