BRD-K88378636_withaferin-a_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

236 genes differentially expressed following the BRD-K88378636_withaferin-a_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AXL AXL receptor tyrosine kinase
BIN1 bridging integrator 1
CAPN2 calpain 2, (m/II) large subunit
CBR3 carbonyl reductase 3
CCL5 chemokine (C-C motif) ligand 5
CD163 CD163 molecule
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CTGF connective tissue growth factor
CTSZ cathepsin Z
CXCL13 chemokine (C-X-C motif) ligand 13
DFNA5 deafness, autosomal dominant 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
DUSP3 dual specificity phosphatase 3
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELL2 elongation factor, RNA polymerase II, 2
EMC3 ER membrane protein complex subunit 3
EPAS1 endothelial PAS domain protein 1
ETV5 ets variant 5
F13A1 coagulation factor XIII, A1 polypeptide
FAM129A family with sequence similarity 129, member A
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
G6PD glucose-6-phosphate dehydrogenase
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA6 GATA binding protein 6
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
GREM1 gremlin 1, DAN family BMP antagonist
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HBEGF heparin-binding EGF-like growth factor
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IL1R2 interleukin 1 receptor, type II
JMJD6 jumonji domain containing 6
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDM3A lysine (K)-specific demethylase 3A
KRT6A keratin 6A, type II
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXRA7 matrix-remodelling associated 7
NPC1 Niemann-Pick disease, type C1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
NRG1 neuregulin 1
P3H2 prolyl 3-hydroxylase 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDZK1IP1 PDZK1 interacting protein 1
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
POPDC3 popeye domain containing 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
RBKS ribokinase
RCAN1 regulator of calcineurin 1
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RND3 Rho family GTPase 3
S100P S100 calcium binding protein P
SDC4 syndecan 4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERTAD2 SERTA domain containing 2
SFN stratifin
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
STK17A serine/threonine kinase 17a
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM110 transmembrane protein 110
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ARG1 arginase 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARMCX2 armadillo repeat containing, X-linked 2
BACE2 beta-site APP-cleaving enzyme 2
C2CD5 C2 calcium-dependent domain containing 5
CCNA2 cyclin A2
CCNF cyclin F
CD200 CD200 molecule
CD24 CD24 molecule
CDK1 cyclin-dependent kinase 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CENPU centromere protein U
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CRABP2 cellular retinoic acid binding protein 2
CRTAP cartilage associated protein
CYB5A cytochrome b5 type A (microsomal)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DMD dystrophin
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYD dihydropyrimidine dehydrogenase
EDNRA endothelin receptor type A
ERBB3 erb-b2 receptor tyrosine kinase 3
EREG epiregulin
ESR1 estrogen receptor 1
EVL Enah/Vasp-like
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GPER1 G protein-coupled estrogen receptor 1
GPNMB glycoprotein (transmembrane) nmb
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP4 insulin-like growth factor binding protein 4
IL1R1 interleukin 1 receptor, type I
ISOC1 isochorismatase domain containing 1
ITM2A integral membrane protein 2A
KIAA0101 KIAA0101
LGALS3 lectin, galactoside-binding, soluble, 3
LMNB1 lamin B1
LOC100505650 uncharacterized LOC100505650
LOXL1 lysyl oxidase-like 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC17 leucine rich repeat containing 17
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAPK13 mitogen-activated protein kinase 13
MARCKSL1 MARCKS-like 1
MCAM melanoma cell adhesion molecule
MCM2 minichromosome maintenance complex component 2
MCM6 minichromosome maintenance complex component 6
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MREG melanoregulin
MYB v-myb avian myeloblastosis viral oncogene homolog
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
OGN osteoglycin
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZRN3 PDZ domain containing ring finger 3
PER3 period circadian clock 3
PLS1 plastin 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAT phosphoribosyl pyrophosphate amidotransferase
PSIP1 PC4 and SFRS1 interacting protein 1
RAB25 RAB25, member RAS oncogene family
RAI2 retinoic acid induced 2
RFC3 replication factor C (activator 1) 3, 38kDa
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RNF130 ring finger protein 130
RRM2 ribonucleotide reductase M2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMAD1 SMAD family member 1
SNRPE small nuclear ribonucleoprotein polypeptide E
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARCL1 SPARC-like 1 (hevin)
SPDEF SAM pointed domain containing ETS transcription factor
SPON1 spondin 1, extracellular matrix protein
STMN1 stathmin 1
SYT1 synaptotagmin I
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TF transferrin
TFRC transferrin receptor
TIAM1 T-cell lymphoma invasion and metastasis 1
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
TRMT5 tRNA methyltransferase 5
TYMS thymidylate synthetase
TYRP1 tyrosinase-related protein 1
UBE2C ubiquitin-conjugating enzyme E2C
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2