BRD-K88378636_withaferin-a_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

181 genes differentially expressed following the BRD-K88378636_withaferin-a_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARC activity-regulated cytoskeleton-associated protein
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
CADM1 cell adhesion molecule 1
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN10 claudin 10
CPT1A carnitine palmitoyltransferase 1A (liver)
CRP C-reactive protein, pentraxin-related
CSRP2 cysteine and glycine-rich protein 2
CXCL12 chemokine (C-X-C motif) ligand 12
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLX2 distal-less homeobox 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EGR1 early growth response 1
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXG1 forkhead box G1
FTH1 ferritin, heavy polypeptide 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GCLM glutamate-cysteine ligase, modifier subunit
GLA galactosidase, alpha
GPM6B glycoprotein M6B
GUSBP11 glucuronidase, beta pseudogene 11
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGLL1 immunoglobulin lambda-like polypeptide 1
IL17RB interleukin 17 receptor B
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
JMJD6 jumonji domain containing 6
KIF14 kinesin family member 14
KRT19 keratin 19, type I
MAGEA1 melanoma antigen family A1
MAOB monoamine oxidase B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NCALD neurocalcin delta
NEFL neurofilament, light polypeptide
NQO1 NAD(P)H dehydrogenase, quinone 1
PEX11A peroxisomal biogenesis factor 11 alpha
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PIR pirin (iron-binding nuclear protein)
PITX1 paired-like homeodomain 1
PLIN2 perilipin 2
PMP22 peripheral myelin protein 22
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRDX2 peroxiredoxin 2
RBKS ribokinase
RBM6 RNA binding motif protein 6
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD6 SMAD family member 6
SPATS2L spermatogenesis associated, serine-rich 2-like
SPP1 secreted phosphoprotein 1
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
TRIM24 tripartite motif containing 24
TXNRD1 thioredoxin reductase 1
UGCG UDP-glucose ceramide glucosyltransferase
WFS1 Wolfram syndrome 1 (wolframin)
WNT5A wingless-type MMTV integration site family, member 5A
ZFP36 ZFP36 ring finger protein
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
BASP1 brain abundant, membrane attached signal protein 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLC Charcot-Leyden crystal galectin
COMP cartilage oligomeric matrix protein
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTSK cathepsin K
CXADR coxsackie virus and adenovirus receptor
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DES desmin
DST dystonin
DUSP4 dual specificity phosphatase 4
EPHA3 EPH receptor A3
EREG epiregulin
EVI2A ecotropic viral integration site 2A
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
FAP fibroblast activation protein, alpha
FBLN1 fibulin 1
FBN1 fibrillin 1
FHL1 four and a half LIM domains 1
FXYD3 FXYD domain containing ion transport regulator 3
GADD45A growth arrest and DNA-damage-inducible, alpha
GREM1 gremlin 1, DAN family BMP antagonist
HBB hemoglobin, beta
HMGA2 high mobility group AT-hook 2
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HOPX HOP homeobox
HOXA10 homeobox A10
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IL1R1 interleukin 1 receptor, type I
IRS1 insulin receptor substrate 1
KCTD12 potassium channel tetramerization domain containing 12
KLF9 Kruppel-like factor 9
KRT7 keratin 7, type II
LDHB lactate dehydrogenase B
LRRC17 leucine rich repeat containing 17
LUM lumican
LXN latexin
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MMP7 matrix metallopeptidase 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYL1 myosin, light chain 1, alkali; skeletal, fast
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PDLIM3 PDZ and LIM domain 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLN phospholamban
POSTN periostin, osteoblast specific factor
PSPH phosphoserine phosphatase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RGS10 regulator of G-protein signaling 10
RGS5 regulator of G-protein signaling 5
RIN2 Ras and Rab interactor 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFRP4 secreted frizzled-related protein 4
SFTPB surfactant protein B
SIK1 salt-inducible kinase 1
SKAP2 src kinase associated phosphoprotein 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLK STE20-like kinase
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNNT1 troponin T type 1 (skeletal, slow)
TSC22D3 TSC22 domain family, member 3
TSPAN8 tetraspanin 8
VCAN versican
VIM vimentin