BRD-K88378636_withaferin-a_MCF10A_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

84 genes differentially expressed following the BRD-K88378636_withaferin-a_MCF10A_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
AKAP12 A kinase (PRKA) anchor protein 12
AQP9 aquaporin 9
CD36 CD36 molecule (thrombospondin receptor)
CXCL8 chemokine (C-X-C motif) ligand 8
EFNB2 ephrin-B2
EFS embryonal Fyn-associated substrate
EGR1 early growth response 1
EGR3 early growth response 3
EIF4B eukaryotic translation initiation factor 4B
EIF5A eukaryotic translation initiation factor 5A
EMX2 empty spiracles homeobox 2
FAM63A family with sequence similarity 63, member A
FKBP5 FK506 binding protein 5
HEPH hephaestin
ICA1 islet cell autoantigen 1, 69kDa
IL13RA2 interleukin 13 receptor, alpha 2
KCTD12 potassium channel tetramerization domain containing 12
KIF5C kinesin family member 5C
MCL1 myeloid cell leukemia 1
NEBL nebulette
NEFL neurofilament, light polypeptide
NFIB nuclear factor I/B
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NRN1 neuritin 1
PCDH9 protocadherin 9
PLBD1 phospholipase B domain containing 1
POU4F1 POU class 4 homeobox 1
PRSS3 protease, serine, 3
PTX3 pentraxin 3, long
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS4 regulator of G-protein signaling 4
SAP30 Sin3A-associated protein, 30kDa
SNAP25 synaptosomal-associated protein, 25kDa
SPRY2 sprouty homolog 2 (Drosophila)
TFF3 trefoil factor 3 (intestinal)
TLR4 toll-like receptor 4
TSPAN8 tetraspanin 8
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BEX4 brain expressed, X-linked 4
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL5 chemokine (C-C motif) ligand 5
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPAS1 endothelial PAS domain protein 1
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HSPA2 heat shock 70kDa protein 2
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
IKZF1 IKAROS family zinc finger 1 (Ikaros)
JCHAIN joining chain of multimeric IgA and IgM
KDM5D lysine (K)-specific demethylase 5D
LITAF lipopolysaccharide-induced TNF factor
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MZB1 marginal zone B and B1 cell-specific protein
NEB nebulin
OPN3 opsin 3
PDGFC platelet derived growth factor C
PEX11A peroxisomal biogenesis factor 11 alpha
PLAU plasminogen activator, urokinase
PLXNC1 plexin C1
RDX radixin
RGS1 regulator of G-protein signaling 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN2 reticulon 2
RUNX3 runt-related transcription factor 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
TMSB15A thymosin beta 15a
TNFAIP8 tumor necrosis factor, alpha-induced protein 8