BRD-K88378636_withaferin-a_MCF10A_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

231 genes differentially expressed following the BRD-K88378636_withaferin-a_MCF10A_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ANO10 anoctamin 10
ANPEP alanyl (membrane) aminopeptidase
APOB apolipoprotein B
APOC1 apolipoprotein C-I
APOE apolipoprotein E
AQP3 aquaporin 3 (Gill blood group)
ASS1 argininosuccinate synthase 1
AVPI1 arginine vasopressin-induced 1
BASP1 brain abundant, membrane attached signal protein 1
BLVRB biliverdin reductase B
BMP4 bone morphogenetic protein 4
C9ORF3 chromosome 9 open reading frame 3
CBR3 carbonyl reductase 3
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CLU clusterin
COLEC12 collectin sub-family member 12
CORO1A coronin, actin binding protein, 1A
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CTSB cathepsin B
CXADR coxsackie virus and adenovirus receptor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAPK1 death-associated protein kinase 1
DHCR24 24-dehydrocholesterol reductase
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DNASE2 deoxyribonuclease II, lysosomal
DSP desmoplakin
DST dystonin
ECM1 extracellular matrix protein 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ENDOD1 endonuclease domain containing 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETFB electron-transfer-flavoprotein, beta polypeptide
FADS1 fatty acid desaturase 1
FADS3 fatty acid desaturase 3
FBP1 fructose-1,6-bisphosphatase 1
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GAA glucosidase, alpha; acid
GABARAPL1 GABA(A) receptor-associated protein like 1
GALC galactosylceramidase
GATA3 GATA binding protein 3
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GPC1 glypican 1
GPX2 glutathione peroxidase 2
GPX4 glutathione peroxidase 4
GSTA1 glutathione S-transferase alpha 1
GSTZ1 glutathione S-transferase zeta 1
H2BFS H2B histone family, member S (pseudogene)
HACD1 3-hydroxyacyl-CoA dehydratase 1
HHLA3 HERV-H LTR-associating 3
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
HMOX1 heme oxygenase 1
HOOK2 hook microtubule-tethering protein 2
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
KRT8 keratin 8, type II
KYNU kynureninase
LAMP2 lysosomal-associated membrane protein 2
LBH limb bud and heart development
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3 lectin, galactoside-binding, soluble, 3
LRP10 low density lipoprotein receptor-related protein 10
LTBP2 latent transforming growth factor beta binding protein 2
LXN latexin
MAP1B microtubule-associated protein 1B
MCOLN1 mucolipin 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL7A methyltransferase like 7A
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MME membrane metallo-endopeptidase
MT1X metallothionein 1X
MVP major vault protein
MYL9 myosin, light chain 9, regulatory
NCF2 neutrophil cytosolic factor 2
NEBL nebulette
NOSIP nitric oxide synthase interacting protein
NQO1 NAD(P)H dehydrogenase, quinone 1
ORAI3 ORAI calcium release-activated calcium modulator 3
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PEG10 paternally expressed 10
PEX11A peroxisomal biogenesis factor 11 alpha
PLIN2 perilipin 2
POR P450 (cytochrome) oxidoreductase
PPAP2B phosphatidic acid phosphatase type 2B
PRDX1 peroxiredoxin 1
PTN pleiotrophin
QPRT quinolinate phosphoribosyltransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
RGCC regulator of cell cycle
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRAD Ras-related associated with diabetes
S100A7 S100 calcium binding protein A7
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMCO4 single-pass membrane protein with coiled-coil domains 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
STXBP2 syntaxin binding protein 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYT1 synaptotagmin I
TBX3 T-box 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM45A transmembrane protein 45A
TNNC1 troponin C type 1 (slow)
TPD52L1 tumor protein D52-like 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIM2 tripartite motif containing 2
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WNT5B wingless-type MMTV integration site family, member 5B
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
AREG amphiregulin
ASCL1 achaete-scute family bHLH transcription factor 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCL2A1 BCL2-related protein A1
BLMH bleomycin hydrolase
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCND2 cyclin D2
CCNF cyclin F
CDC45 cell division cycle 45
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CHD7 chromodomain helicase DNA binding protein 7
COPS8 COP9 signalosome subunit 8
CREB1 cAMP responsive element binding protein 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DBF4 DBF4 zinc finger
DKC1 dyskeratosis congenita 1, dyskerin
DLD dihydrolipoamide dehydrogenase
DNM1L dynamin 1-like
DUSP6 dual specificity phosphatase 6
ENO1 enolase 1, (alpha)
EREG epiregulin
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FOXM1 forkhead box M1
G0S2 G0/G1 switch 2
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GBP1 guanylate binding protein 1, interferon-inducible
GTPBP4 GTP binding protein 4
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1B interleukin 1, beta
INHBA inhibin, beta A
ITGA6 integrin, alpha 6
LAMB1 laminin, beta 1
LAMP5 lysosomal-associated membrane protein family, member 5
LBR lamin B receptor
MREG melanoregulin
MRPS2 mitochondrial ribosomal protein S2
NBN nibrin
OAT ornithine aminotransferase
PBK PDZ binding kinase
PLAT plasminogen activator, tissue
PPIF peptidylprolyl isomerase F
PSAT1 phosphoserine aminotransferase 1
PUS7 pseudouridylate synthase 7 (putative)
QDPR quinoid dihydropteridine reductase
RBM34 RNA binding motif protein 34
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RPL10 ribosomal protein L10
SCGB1D2 secretoglobin, family 1D, member 2
SCML1 sex comb on midleg-like 1 (Drosophila)
SFRP4 secreted frizzled-related protein 4
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
SRSF1 serine/arginine-rich splicing factor 1
STMN1 stathmin 1
TFAM transcription factor A, mitochondrial
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TOP2A topoisomerase (DNA) II alpha 170kDa
TXNDC9 thioredoxin domain containing 9
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WEE1 WEE1 G2 checkpoint kinase
ZNF22 zinc finger protein 22