BRD-K88378636_withaferin-a_LNCAP_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

58 genes differentially expressed following the BRD-K88378636_withaferin-a_LNCAP_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CLU clusterin
CTSB cathepsin B
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FZD7 frizzled class receptor 7
HMOX1 heme oxygenase 1
HOXC10 homeobox C10
HOXC6 homeobox C6
HSPA6 heat shock 70kDa protein 6 (HSP70B')
MARCKS myristoylated alanine-rich protein kinase C substrate
MCOLN1 mucolipin 1
MFAP5 microfibrillar associated protein 5
MTA1 metastasis associated 1
NQO1 NAD(P)H dehydrogenase, quinone 1
PAX5 paired box 5
RCAN1 regulator of calcineurin 1
SATB1 SATB homeobox 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNC tenascin C
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ADGRG6 adhesion G protein-coupled receptor G6
ANXA3 annexin A3
ARHGAP29 Rho GTPase activating protein 29
BCHE butyrylcholinesterase
C3 complement component 3
CTSH cathepsin H
DLK1 delta-like 1 homolog (Drosophila)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP4 fatty acid binding protein 4, adipocyte
G0S2 G0/G1 switch 2
GATA2 GATA binding protein 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
MBOAT7 membrane bound O-acyltransferase domain containing 7
MME membrane metallo-endopeptidase
PLAGL1 pleiomorphic adenoma gene-like 1
PROM1 prominin 1
PTPRE protein tyrosine phosphatase, receptor type, E
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RTN1 reticulon 1
SST somatostatin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TSPAN12 tetraspanin 12
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VNN1 vanin 1