BRD-K88378636_withaferin-a_HT29_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

338 genes differentially expressed following the BRD-K88378636_withaferin-a_HT29_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ACSF2 acyl-CoA synthetase family member 2
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADIRF adipogenesis regulatory factor
AKR1C3 aldo-keto reductase family 1, member C3
AMACR alpha-methylacyl-CoA racemase
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANPEP alanyl (membrane) aminopeptidase
ANXA4 annexin A4
ARMCX1 armadillo repeat containing, X-linked 1
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BEX4 brain expressed, X-linked 4
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C1RL complement component 1, r subcomponent-like
CALCOCO1 calcium binding and coiled-coil domain 1
CAT catalase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFB complement factor B
CLIC5 chloride intracellular channel 5
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CTSA cathepsin A
CTSB cathepsin B
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
EFHC1 EF-hand domain (C-terminal) containing 1
EFNA1 ephrin-A1
EMX2 empty spiracles homeobox 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP3 fatty acid binding protein 3, muscle and heart
FAM13A family with sequence similarity 13, member A
FAM65B family with sequence similarity 65, member B
FBN2 fibrillin 2
FGFR2 fibroblast growth factor receptor 2
FMO5 flavin containing monooxygenase 5
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GLUL glutamate-ammonia ligase
GOLPH3L golgi phosphoprotein 3-like
GSN gelsolin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HEPH hephaestin
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-E major histocompatibility complex, class I, E
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
HMOX1 heme oxygenase 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IL1R1 interleukin 1 receptor, type I
ITM2C integral membrane protein 2C
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM3A lysine (K)-specific demethylase 3A
KLHL24 kelch-like family member 24
KRT20 keratin 20, type I
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LIMK2 LIM domain kinase 2
LXN latexin
LZTFL1 leucine zipper transcription factor-like 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1A1 mannosidase, alpha, class 1A, member 1
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MICALL1 MICAL-like 1
MKL2 MKL/myocardin-like 2
MME membrane metallo-endopeptidase
MT1F metallothionein 1F
MTMR11 myotubularin related protein 11
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
N4BP2L2 NEDD4 binding protein 2-like 2
NCOA2 nuclear receptor coactivator 2
NEU1 sialidase 1 (lysosomal sialidase)
NOV nephroblastoma overexpressed
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PBLD phenazine biosynthesis-like protein domain containing
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1IP1 PDZK1 interacting protein 1
PHYH phytanoyl-CoA 2-hydroxylase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PROM1 prominin 1
PROS1 protein S (alpha)
PRR15L proline rich 15-like
PSAP prosaposin
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRK protein tyrosine phosphatase, receptor type, K
QPRT quinolinate phosphoribosyltransferase
RAB29 RAB29, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RB1CC1 RB1-inducible coiled-coil 1
REEP1 receptor accessory protein 1
REG1A regenerating islet-derived 1 alpha
RPS4Y1 ribosomal protein S4, Y-linked 1
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SEPP1 selenoprotein P, plasma, 1
SESN1 sestrin 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3YL1 SH3 and SYLF domain containing 1
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC22A18 solute carrier family 22, member 18
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC35E2B solute carrier family 35, member E2B
SLC44A4 solute carrier family 44, member 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOX4 SRY (sex determining region Y)-box 4
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYF2 SYF2 pre-mRNA-splicing factor
TMC5 transmembrane channel-like 5
TMEM59 transmembrane protein 59
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOB1 transducer of ERBB2, 1
TP53I3 tumor protein p53 inducible protein 3
TP53TG1 TP53 target 1 (non-protein coding)
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TSPAN31 tetraspanin 31
TST thiosulfate sulfurtransferase (rhodanese)
TTC39A tetratricopeptide repeat domain 39A
TWIST1 twist family bHLH transcription factor 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
VIM vimentin
WBP1L WW domain binding protein 1-like
WDR19 WD repeat domain 19
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZSWIM8 zinc finger, SWIM-type containing 8

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AMD1 adenosylmethionine decarboxylase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ASF1B anti-silencing function 1B histone chaperone
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BYSL bystin-like
C1QBP complement component 1, q subcomponent binding protein
CCDC86 coiled-coil domain containing 86
CCNA2 cyclin A2
CCNB1 cyclin B1
CD3EAP CD3e molecule, epsilon associated protein
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CIT citron rho-interacting serine/threonine kinase
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTPS1 CTP synthase 1
DBF4 DBF4 zinc finger
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DHFR dihydrofolate reductase
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPH2 DPH2 homolog (S. cerevisiae)
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ELOVL6 ELOVL fatty acid elongase 6
ENO1 enolase 1, (alpha)
EREG epiregulin
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM216A family with sequence similarity 216, member A
FEN1 flap structure-specific endonuclease 1
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FST follistatin
GAL galanin/GMAP prepropeptide
GEMIN4 gem (nuclear organelle) associated protein 4
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRWD1 glutamate-rich WD repeat containing 1
GTPBP4 GTP binding protein 4
H2AFX H2A histone family, member X
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IARS isoleucyl-tRNA synthetase
ICAM2 intercellular adhesion molecule 2
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IGL immunoglobulin lambda locus
INPP1 inositol polyphosphate-1-phosphatase
ITGB5 integrin, beta 5
KIAA0020 KIAA0020
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LMNB1 lamin B1
LMNB2 lamin B2
LOXL1 lysyl oxidase-like 1
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MRPS2 mitochondrial ribosomal protein S2
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTCL1 microtubule crosslinking factor 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT10 N-acetyltransferase 10 (GCN5-related)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPM3 nucleophosmin/nucleoplasmin 3
ODC1 ornithine decarboxylase 1
OIP5 Opa interacting protein 5
PA2G4 proliferation-associated 2G4, 38kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PFAS phosphoribosylformylglycinamidine synthase
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAT phosphoribosyl pyrophosphate amidotransferase
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PRMT1 protein arginine methyltransferase 1
PRMT5 protein arginine methyltransferase 5
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PSAT1 phosphoserine aminotransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PUS7 pseudouridylate synthase 7 (putative)
PYCR1 pyrroline-5-carboxylate reductase 1
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAN RAN, member RAS oncogene family
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEH1L SEH1-like (S. cerevisiae)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SPC25 SPC25, NDC80 kinetochore complex component
SRM spermidine synthase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TM4SF1 transmembrane 4 L six family member 1
TMPO thymopoietin
TMX2 thioredoxin-related transmembrane protein 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCK2 uridine-cytidine kinase 2
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein