BRD-K88378636_withaferin-a_HME1_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

238 genes differentially expressed following the BRD-K88378636_withaferin-a_HME1_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD3 abhydrolase domain containing 3
ACKR3 atypical chemokine receptor 3
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDOC aldolase C, fructose-bisphosphate
ARC activity-regulated cytoskeleton-associated protein
ASCL1 achaete-scute family bHLH transcription factor 1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCHE butyrylcholinesterase
BLNK B-cell linker
BPIFA1 BPI fold containing family A, member 1
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C6ORF48 chromosome 6 open reading frame 48
C9ORF16 chromosome 9 open reading frame 16
C9ORF91 chromosome 9 open reading frame 91
CCR7 chemokine (C-C motif) receptor 7
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2AIP CDKN2A interacting protein
CLDN3 claudin 3
CLEC3B C-type lectin domain family 3, member B
COL3A1 collagen, type III, alpha 1
CRABP1 cellular retinoic acid binding protein 1
CTH cystathionine gamma-lyase
CXCL13 chemokine (C-X-C motif) ligand 13
DDIT3 DNA-damage-inducible transcript 3
DHCR7 7-dehydrocholesterol reductase
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPT dermatopontin
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP3 dual specificity phosphatase 3
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR1 early growth response 1
EGR3 early growth response 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
FABP1 fatty acid binding protein 1, liver
FAM117A family with sequence similarity 117, member A
FAM13B family with sequence similarity 13, member B
FAM53C family with sequence similarity 53, member C
FAXDC2 fatty acid hydroxylase domain containing 2
FGL2 fibrinogen-like 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO4 forkhead box O4
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GATA2 GATA binding protein 2
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GPRASP1 G protein-coupled receptor associated sorting protein 1
HAL histidine ammonia-lyase
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IL17RB interleukin 17 receptor B
INSIG1 insulin induced gene 1
IQCG IQ motif containing G
ISL1 ISL LIM homeobox 1
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LDLR low density lipoprotein receptor
LEF1 lymphoid enhancer-binding factor 1
LEFTY1 left-right determination factor 1
LPIN2 lipin 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOA monoamine oxidase A
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEF2C myocyte enhancer factor 2C
MLF1 myeloid leukemia factor 1
MSX1 msh homeobox 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXI1 MAX interactor 1, dimerization protein
MYLIP myosin regulatory light chain interacting protein
NEU1 sialidase 1 (lysosomal sialidase)
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPL1 nucleoporin like 1
NUPR1 nuclear protein, transcriptional regulator, 1
PARM1 prostate androgen-regulated mucin-like protein 1
PCP4 Purkinje cell protein 4
PEG3 paternally expressed 3
PLAGL1 pleiomorphic adenoma gene-like 1
PLBD1 phospholipase B domain containing 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RNASET2 ribonuclease T2
RNMT RNA (guanine-7-) methyltransferase
RYBP RING1 and YY1 binding protein
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERINC5 serine incorporator 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SQLE squalene epoxidase
SRSF7 serine/arginine-rich splicing factor 7
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TFF3 trefoil factor 3 (intestinal)
TGFA transforming growth factor, alpha
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAF4 TNF receptor-associated factor 4
TRBC1 T cell receptor beta constant 1
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
VNN1 vanin 1
XCL1 chemokine (C motif) ligand 1
XK X-linked Kx blood group
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein
ZNF165 zinc finger protein 165
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
AHNAK2 AHNAK nucleoprotein 2
ANXA3 annexin A3
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
AURKA aurora kinase A
B3GNT1
CA12 carbonic anhydrase XII
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CDC20 cell division cycle 20
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COASY CoA synthase
CSE1L CSE1 chromosome segregation 1-like (yeast)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DOCK4 dedicator of cytokinesis 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EREG epiregulin
FEN1 flap structure-specific endonuclease 1
FLNB filamin B, beta
GAS1 growth arrest-specific 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GRWD1 glutamate-rich WD repeat containing 1
HOPX HOP homeobox
HSPG2 heparan sulfate proteoglycan 2
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ITGA6 integrin, alpha 6
KANK1 KN motif and ankyrin repeat domains 1
KIF20A kinesin family member 20A
KLHL9 kelch-like family member 9
LAMB1 laminin, beta 1
LAPTM4B lysosomal protein transmembrane 4 beta
LTBP2 latent transforming growth factor beta binding protein 2
MALL mal, T-cell differentiation protein-like
MRPL15 mitochondrial ribosomal protein L15
MRPS16 mitochondrial ribosomal protein S16
NFIB nuclear factor I/B
NNMT nicotinamide N-methyltransferase
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFC platelet derived growth factor C
PLK1 polo-like kinase 1
PON2 paraoxonase 2
POSTN periostin, osteoblast specific factor
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRSS23 protease, serine, 23
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
PXDN peroxidasin
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SMAD3 SMAD family member 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53I3 tumor protein p53 inducible protein 3
TUBG1 tubulin, gamma 1