BRD-K88378636_withaferin-a_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

219 genes differentially expressed following the BRD-K88378636_withaferin-a_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ACOT13 acyl-CoA thioesterase 13
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ASS1 argininosuccinate synthase 1
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BAG2 BCL2-associated athanogene 2
BAG3 BCL2-associated athanogene 3
BID BH3 interacting domain death agonist
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CENPE centromere protein E, 312kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
CRABP1 cellular retinoic acid binding protein 1
CTSL cathepsin L
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DMBT1 deleted in malignant brain tumors 1
ELANE elastase, neutrophil expressed
EMP2 epithelial membrane protein 2
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FAM46A family with sequence similarity 46, member A
FOSL1 FOS-like antigen 1
FRZB frizzled-related protein
G6PD glucose-6-phosphate dehydrogenase
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GAL galanin/GMAP prepropeptide
GATA2 GATA binding protein 2
GLUL glutamate-ammonia ligase
GOLM1 golgi membrane protein 1
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
H2BFS H2B histone family, member S (pseudogene)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HPCAL1 hippocalcin-like 1
HSDL2 hydroxysteroid dehydrogenase like 2
HSPB8 heat shock 22kDa protein 8
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KIAA0368 KIAA0368
LAMP3 lysosomal-associated membrane protein 3
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MAST4 microtubule associated serine/threonine kinase family member 4
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLPH melanophilin
MMP12 matrix metallopeptidase 12
MTCL1 microtubule crosslinking factor 1
MUC1 mucin 1, cell surface associated
MXRA7 matrix-remodelling associated 7
MYH11 myosin, heavy chain 11, smooth muscle
NEFL neurofilament, light polypeptide
NQO1 NAD(P)H dehydrogenase, quinone 1
PDIA3 protein disulfide isomerase family A, member 3
PDZK1IP1 PDZK1 interacting protein 1
PLAC8 placenta-specific 8
PTN pleiotrophin
RAD50 RAD50 homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK1 serine peptidase inhibitor, Kazal type 1
SQSTM1 sequestosome 1
STAR steroidogenic acute regulatory protein
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TDP2 tyrosyl-DNA phosphodiesterase 2
TFF1 trefoil factor 1
TNC tenascin C
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TUBB6 tubulin, beta 6 class V
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHR aryl hydrocarbon receptor
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARID5B AT rich interactive domain 5B (MRF1-like)
BCHE butyrylcholinesterase
BGN biglycan
C5 complement component 5
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CFH complement factor H
CFHR2 complement factor H-related 2
CFI complement factor I
CHL1 cell adhesion molecule L1-like
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COG2 component of oligomeric golgi complex 2
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CPB2 carboxypeptidase B2 (plasma)
DCHS1 dachsous cadherin-related 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
EAPP E2F-associated phosphoprotein
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
F2R coagulation factor II (thrombin) receptor
FBN2 fibrillin 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FGL1 fibrinogen-like 1
FXYD2 FXYD domain containing ion transport regulator 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP1 guanylate binding protein 1, interferon-inducible
GC group-specific component (vitamin D binding protein)
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLDC glycine dehydrogenase (decarboxylating)
GLUD1 glutamate dehydrogenase 1
GOLT1B golgi transport 1B
GRB14 growth factor receptor-bound protein 14
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNMT histamine N-methyltransferase
HOXB2 homeobox B2
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFI16 interferon, gamma-inducible protein 16
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP1 insulin-like growth factor binding protein 1
IGFBP7 insulin-like growth factor binding protein 7
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
INSIG2 insulin induced gene 2
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
ITM2C integral membrane protein 2C
JADE3 jade family PHD finger 3
KCTD12 potassium channel tetramerization domain containing 12
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT8 keratin 8, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LPAR6 lysophosphatidic acid receptor 6
LUM lumican
LYPLA1 lysophospholipase I
MAL mal, T-cell differentiation protein
MLANA melan-A
MRPL15 mitochondrial ribosomal protein L15
MXRA5 matrix-remodelling associated 5
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
OXTR oxytocin receptor
PAH phenylalanine hydroxylase
PCCB propionyl CoA carboxylase, beta polypeptide
PDHB pyruvate dehydrogenase (lipoamide) beta
PERP PERP, TP53 apoptosis effector
PFKL phosphofructokinase, liver
PLAT plasminogen activator, tissue
PLK2 polo-like kinase 2
PNMA2 paraneoplastic Ma antigen 2
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POSTN periostin, osteoblast specific factor
PSPH phosphoserine phosphatase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PXMP2 peroxisomal membrane protein 2, 22kDa
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBM3 RNA binding motif (RNP1, RRM) protein 3
RELN reelin
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SPTSSA serine palmitoyltransferase, small subunit A
SRGN serglycin
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SULF1 sulfatase 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
THAP11 THAP domain containing 11
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TMED7 transmembrane emp24 protein transport domain containing 7
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN4 tetraspanin 4
TUBA1A tubulin, alpha 1a
TXNDC9 thioredoxin domain containing 9
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAM1 vascular cell adhesion molecule 1
WSB1 WD repeat and SOCS box containing 1