BRD-K88378636_withaferin-a_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K88378636_withaferin-a_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABHD4 abhydrolase domain containing 4
ACAA1 acetyl-CoA acyltransferase 1
ACSL1 acyl-CoA synthetase long-chain family member 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALAD aminolevulinate dehydratase
BID BH3 interacting domain death agonist
BLNK B-cell linker
C2CD2 C2 calcium-dependent domain containing 2
CAT catalase
CFB complement factor B
CLU clusterin
COLEC12 collectin sub-family member 12
CSTA cystatin A (stefin A)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYTH1 cytohesin 1
EGFR epidermal growth factor receptor
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FMO5 flavin containing monooxygenase 5
FOXO4 forkhead box O4
GFOD1 glucose-fructose oxidoreductase domain containing 1
GLUL glutamate-ammonia ligase
GSTA4 glutathione S-transferase alpha 4
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
HSDL2 hydroxysteroid dehydrogenase like 2
HSPA2 heat shock 70kDa protein 2
IGL immunoglobulin lambda locus
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL17RB interleukin 17 receptor B
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KYNU kynureninase
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMCH1 LIM and calponin homology domains 1
LTF lactotransferrin
MAGEA3 melanoma antigen family A3
MAN1C1 mannosidase, alpha, class 1C, member 1
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
MTSS1 metastasis suppressor 1
MYO10 myosin X
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUPR1 nuclear protein, transcriptional regulator, 1
PADI2 peptidyl arginine deiminase, type II
PDLIM1 PDZ and LIM domain 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
S100A8 S100 calcium binding protein A8
SATB1 SATB homeobox 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TF transferrin
TSPYL5 TSPY-like 5
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDOA aldolase A, fructose-bisphosphate
ANXA3 annexin A3
CBFB core-binding factor, beta subunit
CD24 CD24 molecule
CD58 CD58 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHIC2 cysteine-rich hydrophobic domain 2
COL3A1 collagen, type III, alpha 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL11 chemokine (C-X-C motif) ligand 11
DUSP6 dual specificity phosphatase 6
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPHA2 EPH receptor A2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAT1 FAT atypical cadherin 1
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GYG1 glycogenin 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
INPP1 inositol polyphosphate-1-phosphatase
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MAP2K3 mitogen-activated protein kinase kinase 3
MGAM maltase-glucoamylase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOLC1 nucleolar and coiled-body phosphoprotein 1
ODC1 ornithine decarboxylase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PNO1 partner of NOB1 homolog (S. cerevisiae)
PNP purine nucleoside phosphorylase
PPAT phosphoribosyl pyrophosphate amidotransferase
RBPMS RNA binding protein with multiple splicing
RRM2 ribonucleotide reductase M2
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPON1 spondin 1, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPTBN1 spectrin, beta, non-erythrocytic 1
TFRC transferrin receptor
THBS1 thrombospondin 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
WT1 Wilms tumor 1
XBP1 X-box binding protein 1