BRD-K88378636_withaferin-a_HCC515_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

215 genes differentially expressed following the BRD-K88378636_withaferin-a_HCC515_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASCL1 achaete-scute family bHLH transcription factor 1
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BAMBI BMP and activin membrane-bound inhibitor
BBS1 Bardet-Biedl syndrome 1
BPIFA1 BPI fold containing family A, member 1
C5 complement component 5
CALD1 caldesmon 1
CAPN1 calpain 1, (mu/I) large subunit
CAT catalase
CCNG2 cyclin G2
CD24 CD24 molecule
CD46 CD46 molecule, complement regulatory protein
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CES1 carboxylesterase 1
CETN2 centrin, EF-hand protein, 2
CFB complement factor B
CLU clusterin
COBL cordon-bleu WH2 repeat protein
COBLL1 cordon-bleu WH2 repeat protein-like 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRYAB crystallin, alpha B
CTSC cathepsin C
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
EFNA1 ephrin-A1
FAM134B family with sequence similarity 134, member B
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
GSTA1 glutathione S-transferase alpha 1
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H2BD histone cluster 1, H2bd
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IFI27 interferon, alpha-inducible protein 27
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
LCN2 lipocalin 2
MAGED2 melanoma antigen family D2
MAMLD1 mastermind-like domain containing 1
MAP7 microtubule-associated protein 7
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MME membrane metallo-endopeptidase
MN1 meningioma (disrupted in balanced translocation) 1
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MVP major vault protein
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
MYO6 myosin VI
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
PALLD palladin, cytoskeletal associated protein
PAM peptidylglycine alpha-amidating monooxygenase
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDZK1 PDZ domain containing 1
PERP PERP, TP53 apoptosis effector
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLTP phospholipid transfer protein
PPL periplakin
PRSS23 protease, serine, 23
PXDN peroxidasin
RBPMS RNA binding protein with multiple splicing
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SATB1 SATB homeobox 1
SC5D sterol-C5-desaturase
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFTPB surfactant protein B
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
SPON2 spondin 2, extracellular matrix protein
STAT1 signal transducer and activator of transcription 1, 91kDa
TACSTD2 tumor-associated calcium signal transducer 2
TARP TCR gamma alternate reading frame protein
TSC22D1 TSC22 domain family, member 1
TSPAN13 tetraspanin 13
TTC39A tetratricopeptide repeat domain 39A
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP8 vesicle-associated membrane protein 8
VAV3 vav 3 guanine nucleotide exchange factor
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CA2 carbonic anhydrase II
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND1 cyclin D1
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CLEC2B C-type lectin domain family 2, member B
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CRISP3 cysteine-rich secretory protein 3
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
ETV1 ets variant 1
ETV5 ets variant 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCI Fanconi anemia, complementation group I
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GDF15 growth differentiation factor 15
GINS1 GINS complex subunit 1 (Psf1 homolog)
H2AFZ H2A histone family, member Z
HBEGF heparin-binding EGF-like growth factor
HELLS helicase, lymphoid-specific
HES1 hes family bHLH transcription factor 1
HJURP Holliday junction recognition protein
HNMT histamine N-methyltransferase
IER3 immediate early response 3
IER5 immediate early response 5
IL13RA2 interleukin 13 receptor, alpha 2
JUN jun proto-oncogene
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
LHFP lipoma HMGIC fusion partner
LIF leukemia inhibitory factor
LYPD1 LY6/PLAUR domain containing 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
MFAP5 microfibrillar associated protein 5
MKI67 marker of proliferation Ki-67
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAPG2 non-SMC condensin II complex, subunit G2
NDC80 NDC80 kinetochore complex component
NEFL neurofilament, light polypeptide
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PPARG peroxisome proliferator-activated receptor gamma
PRC1 protein regulator of cytokinesis 1
PRPF4 pre-mRNA processing factor 4
PSRC1 proline/serine-rich coiled-coil 1
PTX3 pentraxin 3, long
RRM2 ribonucleotide reductase M2
SATB2 SATB homeobox 2
SH2B3 SH2B adaptor protein 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNAI2 snail family zinc finger 2
SPON1 spondin 1, extracellular matrix protein
SPRY2 sprouty homolog 2 (Drosophila)
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFDP1 transcription factor Dp-1
TLR4 toll-like receptor 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TWIST1 twist family bHLH transcription factor 1
TYMS thymidylate synthetase
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
USP1 ubiquitin specific peptidase 1
WT1 Wilms tumor 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein