BRD-K88378636_withaferin-a_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

268 genes differentially expressed following the BRD-K88378636_withaferin-a_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD5 abhydrolase domain containing 5
AIM2 absent in melanoma 2
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALAS1 5'-aminolevulinate synthase 1
ANXA1 annexin A1
AP1G1 adaptor-related protein complex 1, gamma 1 subunit
APOC1 apolipoprotein C-I
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BLVRB biliverdin reductase B
CA2 carbonic anhydrase II
CAB39 calcium binding protein 39
CALCOCO2 calcium binding and coiled-coil domain 2
CBR1 carbonyl reductase 1
CCND1 cyclin D1
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CGA glycoprotein hormones, alpha polypeptide
CHIC2 cysteine-rich hydrophobic domain 2
CIDEC cell death-inducing DFFA-like effector c
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLTB clathrin, light chain B
CRABP1 cellular retinoic acid binding protein 1
CTSL cathepsin L
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DENND1B DENN/MADD domain containing 1B
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPP4 dipeptidyl-peptidase 4
DSP desmoplakin
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV5 ets variant 5
FBXO11 F-box protein 11
FTH1 ferritin, heavy polypeptide 1
GAL galanin/GMAP prepropeptide
GATA3 GATA binding protein 3
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GLA galactosidase, alpha
GLRX glutaredoxin (thioltransferase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPX3 glutathione peroxidase 3
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDO1 indoleamine 2,3-dioxygenase 1
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JADE2 jade family PHD finger 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLK5 kallikrein-related peptidase 5
KRT6A keratin 6A, type II
KRT7 keratin 7, type II
KYNU kynureninase
LYRM1 LYR motif containing 1
MCOLN1 mucolipin 1
MT1F metallothionein 1F
MT1M metallothionein 1M
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NELL2 NEL-like 2 (chicken)
NEU1 sialidase 1 (lysosomal sialidase)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NQO1 NAD(P)H dehydrogenase, quinone 1
NTS neurotensin
ODC1 ornithine decarboxylase 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
POPDC3 popeye domain containing 3
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCQ protein kinase C, theta
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RALBP1 ralA binding protein 1
RAP1GAP RAP1 GTPase activating protein
RB1CC1 RB1-inducible coiled-coil 1
RNF24 ring finger protein 24
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SNX11 sorting nexin 11
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
STXBP1 syntaxin binding protein 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBX3 T-box 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR3 transforming growth factor, beta receptor III
TRIM2 tripartite motif containing 2
TXNRD1 thioredoxin reductase 1
WDR7 WD repeat domain 7
WWP1 WW domain containing E3 ubiquitin protein ligase 1

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACKR3 atypical chemokine receptor 3
ACTC1 actin, alpha, cardiac muscle 1
ADGRG1 adhesion G protein-coupled receptor G1
AEBP1 AE binding protein 1
AGRN agrin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA4 annexin A4
ANXA6 annexin A6
APOD apolipoprotein D
APOLD1 apolipoprotein L domain containing 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASCL1 achaete-scute family bHLH transcription factor 1
ASS1 argininosuccinate synthase 1
AUTS2 autism susceptibility candidate 2
BASP1 brain abundant, membrane attached signal protein 1
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BTBD3 BTB (POZ) domain containing 3
C10ORF10 chromosome 10 open reading frame 10
CA12 carbonic anhydrase XII
CALD1 caldesmon 1
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCNE2 cyclin E2
CCNG1 cyclin G1
CD24 CD24 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHSY1 chondroitin sulfate synthase 1
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COL14A1 collagen, type XIV, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
COMP cartilage oligomeric matrix protein
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5A cytochrome b5 type A (microsomal)
CYTH1 cytohesin 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DES desmin
DMD dystrophin
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
EDN1 endothelin 1
EGR3 early growth response 3
EHF ets homologous factor
ENO1 enolase 1, (alpha)
ERAP2 endoplasmic reticulum aminopeptidase 2
EVL Enah/Vasp-like
F2R coagulation factor II (thrombin) receptor
FAM171A1 family with sequence similarity 171, member A1
FBLN1 fibulin 1
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HDAC6 histone deacetylase 6
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGB3 high mobility group box 3
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
HOXA10 homeobox A10
ICAM1 intercellular adhesion molecule 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFI6 interferon, alpha-inducible protein 6
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL32 interleukin 32
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JAG1 jagged 1
KIF20A kinesin family member 20A
KLF6 Kruppel-like factor 6
LAPTM4B lysosomal protein transmembrane 4 beta
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIG1 ligase I, DNA, ATP-dependent
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC17 leucine rich repeat containing 17
LY6D lymphocyte antigen 6 complex, locus D
LY6E lymphocyte antigen 6 complex, locus E
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEH1 melanoma antigen family H1
MATN2 matrilin 2
MCAM melanoma cell adhesion molecule
MCM7 minichromosome maintenance complex component 7
MEIS1 Meis homeobox 1
MGP matrix Gla protein
MMP2 matrix metallopeptidase 2
MX1 MX dynamin-like GTPase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYH10 myosin, heavy chain 10, non-muscle
MYH11 myosin, heavy chain 11, smooth muscle
MYLK myosin light chain kinase
NAP1L1 nucleosome assembly protein 1-like 1
NDN necdin, melanoma antigen (MAGE) family member
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NREP neuronal regeneration related protein
NXN nucleoredoxin
OLFM4 olfactomedin 4
PBX1 pre-B-cell leukemia homeobox 1
PDLIM2 PDZ and LIM domain 2 (mystique)
PDLIM3 PDZ and LIM domain 3
PDZK1 PDZ domain containing 1
PLN phospholamban
PNMA2 paraneoplastic Ma antigen 2
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRDX2 peroxiredoxin 2
PRSS23 protease, serine, 23
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGIS prostaglandin I2 (prostacyclin) synthase
PXMP2 peroxisomal membrane protein 2, 22kDa
PYGL phosphorylase, glycogen, liver
RBM3 RNA binding motif (RNP1, RRM) protein 3
REPIN1 replication initiator 1
RHOB ras homolog family member B
RPL10 ribosomal protein L10
RPL22 ribosomal protein L22
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCD5 stearoyl-CoA desaturase 5
SDC2 syndecan 2
SEC23A Sec23 homolog A (S. cerevisiae)
SELE selectin E
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SH3YL1 SH3 and SYLF domain containing 1
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQLE squalene epoxidase
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TBCB tubulin folding cofactor B
TGM2 transglutaminase 2
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLR4 toll-like receptor 4
TMEM123 transmembrane protein 123
TMSB15A thymosin beta 15a
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPM1 tropomyosin 1 (alpha)
TSPAN8 tetraspanin 8
TTC3 tetratricopeptide repeat domain 3
TYMS thymidylate synthetase
UQCRC2 ubiquinol-cytochrome c reductase core protein II
VCAN versican
ZBTB18 zinc finger and BTB domain containing 18