BRD-K88378636_withaferin-a_A549_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

241 genes differentially expressed following the BRD-K88378636_withaferin-a_A549_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ACOT9 acyl-CoA thioesterase 9
AIF1 allograft inflammatory factor 1
AKR1C3 aldo-keto reductase family 1, member C3
ANPEP alanyl (membrane) aminopeptidase
ANXA4 annexin A4
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
C1RL complement component 1, r subcomponent-like
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAST calpastatin
CAT catalase
CBR3 carbonyl reductase 3
CD36 CD36 molecule (thrombospondin receptor)
CD40 CD40 molecule, TNF receptor superfamily member 5
CGA glycoprotein hormones, alpha polypeptide
CLU clusterin
CPQ carboxypeptidase Q
CRYAB crystallin, alpha B
CXCL14 chemokine (C-X-C motif) ligand 14
CYFIP1 cytoplasmic FMR1 interacting protein 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DFNA5 deafness, autosomal dominant 5
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
E2F2 E2F transcription factor 2
ECHDC2 enoyl CoA hydratase domain containing 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
EFNA1 ephrin-A1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM114A1 family with sequence similarity 114, member A1
FAM134B family with sequence similarity 134, member B
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXO4 forkhead box O4
FXYD3 FXYD domain containing ion transport regulator 3
GABARAPL1 GABA(A) receptor-associated protein like 1
GAS1 growth arrest-specific 1
GBAS glioblastoma amplified sequence
GBP1 guanylate binding protein 1, interferon-inducible
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLUL glutamate-ammonia ligase
GPX4 glutathione peroxidase 4
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
IFI27 interferon, alpha-inducible protein 27
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLK5 kallikrein-related peptidase 5
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
LAMA3 laminin, alpha 3
LOX lysyl oxidase
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP7 microtubule-associated protein 7
MAPT microtubule-associated protein tau
MATN2 matrilin 2
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MX2 MX dynamin-like GTPase 2
MYO6 myosin VI
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NINJ1 ninjurin 1
NPEPL1 aminopeptidase-like 1
NREP neuronal regeneration related protein
NUPR1 nuclear protein, transcriptional regulator, 1
OBSL1 obscurin-like 1
PBLD phenazine biosynthesis-like protein domain containing
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1IP1 PDZK1 interacting protein 1
PHYH phytanoyl-CoA 2-hydroxylase
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLTP phospholipid transfer protein
PNRC1 proline-rich nuclear receptor coactivator 1
PRUNE2 prune homolog 2 (Drosophila)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RAB9A RAB9A, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCAN1 regulator of calcineurin 1
RHOB ras homolog family member B
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SDC4 syndecan 4
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFXN3 sideroflexin 3
SH3GLB1 SH3-domain GRB2-like endophilin B1
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPATA20 spermatogenesis associated 20
SPTSSA serine palmitoyltransferase, small subunit A
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STOM stomatin
STX12 syntaxin 12
STXBP2 syntaxin binding protein 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYNGR3 synaptogyrin 3
TCEA2 transcription elongation factor A (SII), 2
TF transferrin
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM165 transmembrane protein 165
TPM2 tropomyosin 2 (beta)
TRAPPC6A trafficking protein particle complex 6A
TSKU tsukushi, small leucine rich proteoglycan
TXNIP thioredoxin interacting protein
UGDH UDP-glucose 6-dehydrogenase
VAMP8 vesicle-associated membrane protein 8
VAT1 vesicle amine transport 1
VWA5A von Willebrand factor A domain containing 5A
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AGR2 anterior gradient 2
AKAP12 A kinase (PRKA) anchor protein 12
ANXA3 annexin A3
ARG1 arginase 1
ARL4C ADP-ribosylation factor-like 4C
BHLHE40 basic helix-loop-helix family, member e40
BOP1 block of proliferation 1
BPI bactericidal/permeability-increasing protein
CCND1 cyclin D1
CCNF cyclin F
CD44 CD44 molecule (Indian blood group)
CD81 CD81 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CEMIP cell migration inducing protein, hyaluronan binding
CENPE centromere protein E, 312kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHEK1 checkpoint kinase 1
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
DBF4 DBF4 zinc finger
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEFA4 defensin, alpha 4, corticostatin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
EREG epiregulin
ETV1 ets variant 1
ETV5 ets variant 5
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GDF15 growth differentiation factor 15
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLI2 GLI family zinc finger 2
GRWD1 glutamate-rich WD repeat containing 1
H1F0 H1 histone family, member 0
HMGA2 high mobility group AT-hook 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
IRS1 insulin receptor substrate 1
KIF14 kinesin family member 14
KLK11 kallikrein-related peptidase 11
LDB2 LIM domain binding 2
LIF leukemia inhibitory factor
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MAPK13 mitogen-activated protein kinase 13
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM7 minichromosome maintenance complex component 7
MLPH melanophilin
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NAV3 neuron navigator 3
NR2F1 nuclear receptor subfamily 2, group F, member 1
NT5E 5'-nucleotidase, ecto (CD73)
ODC1 ornithine decarboxylase 1
PAK1IP1 PAK1 interacting protein 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKCH protein kinase C, eta
PRSS3 protease, serine, 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAP1GAP RAP1 GTPase activating protein
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS2 regulator of G-protein signaling 2
RND3 Rho family GTPase 3
RRM2 ribonucleotide reductase M2
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SHCBP1 SHC SH2-domain binding protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
SYT1 synaptotagmin I
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TBPL1 TBP-like 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TIPIN TIMELESS interacting protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIB2 tribbles pseudokinase 2
TSPAN8 tetraspanin 8
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
ZBTB18 zinc finger and BTB domain containing 18