BRD-K88378636_withaferin-a_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

272 genes differentially expressed following the BRD-K88378636_withaferin-a_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDOC aldolase C, fructose-bisphosphate
ANXA4 annexin A4
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAX BCL2-associated X protein
BEX4 brain expressed, X-linked 4
BTG2 BTG family, member 2
C6ORF48 chromosome 6 open reading frame 48
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCND2 cyclin D2
CCNG1 cyclin G1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES2 carboxylesterase 2
CFB complement factor B
CLU clusterin
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL4A5 collagen, type IV, alpha 5
COL9A2 collagen, type IX, alpha 2
CRYAB crystallin, alpha B
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAPK1 death-associated protein kinase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DENND1B DENN/MADD domain containing 1B
DRAM1 DNA-damage regulated autophagy modulator 1
EFNA1 ephrin-A1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB2 erb-b2 receptor tyrosine kinase 2
FADS3 fatty acid desaturase 3
FAM134B family with sequence similarity 134, member B
FDXR ferredoxin reductase
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GAS6 growth arrest-specific 6
GATA2 GATA binding protein 2
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLS glutaminase
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPNMB glycoprotein (transmembrane) nmb
GPRC5B G protein-coupled receptor, class C, group 5, member B
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
ISYNA1 inositol-3-phosphate synthase 1
KAZN kazrin, periplakin interacting protein
KIF1A kinesin family member 1A
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LPAR6 lysophosphatidic acid receptor 6
MAGED2 melanoma antigen family D2
MATN2 matrilin 2
MYL9 myosin, light chain 9, regulatory
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
NOTCH1 notch 1
NOV nephroblastoma overexpressed
NUPR1 nuclear protein, transcriptional regulator, 1
OBSL1 obscurin-like 1
OPLAH 5-oxoprolinase (ATP-hydrolysing)
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
OSBPL9 oxysterol binding protein-like 9
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDLIM1 PDZ and LIM domain 1
PGAP3 post-GPI attachment to proteins 3
PNRC1 proline-rich nuclear receptor coactivator 1
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
QPRT quinolinate phosphoribosyltransferase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RNASET2 ribonuclease T2
RPL31 ribosomal protein L31
RPS27L ribosomal protein S27-like
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX2 SRY (sex determining region Y)-box 2
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SSPN sarcospan
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TMEM35 transmembrane protein 35
TOX thymocyte selection-associated high mobility group box
TPD52L1 tumor protein D52-like 1
TRIM22 tripartite motif containing 22
TTC39A tetratricopeptide repeat domain 39A
TUSC3 tumor suppressor candidate 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WFDC1 WAP four-disulfide core domain 1
WSB1 WD repeat and SOCS box containing 1
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACSL1 acyl-CoA synthetase long-chain family member 1
AGTR1 angiotensin II receptor, type 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANO1 anoctamin 1, calcium activated chloride channel
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOLD1 apolipoprotein L domain containing 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASF1B anti-silencing function 1B histone chaperone
ASPH aspartate beta-hydroxylase
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCDC109B coiled-coil domain containing 109B
CCNA2 cyclin A2
CCND1 cyclin D1
CCNE2 cyclin E2
CCNF cyclin F
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL6A2 collagen, type VI, alpha 2
CST1 cystatin SN
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYR61 cysteine-rich, angiogenic inducer, 61
DBF4 DBF4 zinc finger
DCBLD2 discoidin, CUB and LCCL domain containing 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFHD2 EF-hand domain family, member D2
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
EREG epiregulin
ETV1 ets variant 1
ETV4 ets variant 4
ETV5 ets variant 5
EXO1 exonuclease 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
F5 coagulation factor V (proaccelerin, labile factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
FXYD5 FXYD domain containing ion transport regulator 5
FZD7 frizzled class receptor 7
GEM GTP binding protein overexpressed in skeletal muscle
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLRX glutaredoxin (thioltransferase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPER1 G protein-coupled estrogen receptor 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTSE1 G-2 and S-phase expressed 1
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HJURP Holliday junction recognition protein
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
IER2 immediate early response 2
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KRT18 keratin 18, type I
LEF1 lymphoid enhancer-binding factor 1
LIF leukemia inhibitory factor
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA12 melanoma antigen family A12
MAGEA6 melanoma antigen family A6
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MKI67 marker of proliferation Ki-67
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAV3 neuron navigator 3
NCAPG non-SMC condensin I complex, subunit G
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NNMT nicotinamide N-methyltransferase
NRGN neurogranin (protein kinase C substrate, RC3)
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
PCSK1 proprotein convertase subtilisin/kexin type 1
PDLIM5 PDZ and LIM domain 5
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PPARG peroxisome proliferator-activated receptor gamma
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RFC2 replication factor C (activator 1) 2, 40kDa
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFRP1 secreted frizzled-related protein 1
SH2B3 SH2B adaptor protein 3
SHCBP1 SHC SH2-domain binding protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMAGP small cell adhesion glycoprotein
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
SPATS2L spermatogenesis associated, serine-rich 2-like
SPC25 SPC25, NDC80 kinetochore complex component
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SRPX2 sushi-repeat containing protein, X-linked 2
STC1 stanniocalcin 1
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIAM1 T-cell lymphoma invasion and metastasis 1
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
TMX4 thioredoxin-related transmembrane protein 4
TNC tenascin C
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TSPAN5 tetraspanin 5
TUBB4B tubulin, beta 4B class IVb
UBE2C ubiquitin-conjugating enzyme E2C
UPP1 uridine phosphorylase 1