BRD-K88329126_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

78 genes differentially expressed following the BRD-K88329126_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
BTG2 BTG family, member 2
CCL2 chemokine (C-C motif) ligand 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIP3 CAP-GLY domain containing linker protein 3
COL1A1 collagen, type I, alpha 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
FAM129A family with sequence similarity 129, member A
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GEM GTP binding protein overexpressed in skeletal muscle
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IGL immunoglobulin lambda locus
IRF1 interferon regulatory factor 1
JUNB jun B proto-oncogene
LAMB3 laminin, beta 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MXI1 MAX interactor 1, dimerization protein
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTN pleiotrophin
PTX3 pentraxin 3, long
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS16 regulator of G-protein signaling 16
SFRP4 secreted frizzled-related protein 4
SOD2 superoxide dismutase 2, mitochondrial
SQSTM1 sequestosome 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAM1 vascular cell adhesion molecule 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
CCNA2 cyclin A2
CCND1 cyclin D1
CD24 CD24 molecule
CHN2 chimerin 2
COL4A1 collagen, type IV, alpha 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTSH cathepsin H
CXADR coxsackie virus and adenovirus receptor
DEFB1 defensin, beta 1
MLPH melanophilin
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
QDPR quinoid dihydropteridine reductase
REG3A regenerating islet-derived 3 alpha
TGFBI transforming growth factor, beta-induced, 68kDa
TUBA4A tubulin, alpha 4a
VCAN versican