BRD-K87990216_Piretanide_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

263 genes differentially expressed following the BRD-K87990216_Piretanide_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADAM22 ADAM metallopeptidase domain 22
ADGRL2 adhesion G protein-coupled receptor L2
AIM1 absent in melanoma 1
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANOS1 anosmin 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARMCX1 armadillo repeat containing, X-linked 1
ATP11B ATPase, class VI, type 11B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
BTG2 BTG family, member 2
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C1ORF56 chromosome 1 open reading frame 56
CA1 carbonic anhydrase I
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL5 chemokine (C-C motif) ligand 5
CCR2 chemokine (C-C motif) receptor 2
CD14 CD14 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD93 CD93 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH13 cadherin 13
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK14 cyclin-dependent kinase 14
CLEC5A C-type lectin domain family 5, member A
CORO1A coronin, actin binding protein, 1A
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCR4 chemokine (C-X-C motif) receptor 4
DCHS1 dachsous cadherin-related 1
DENND1B DENN/MADD domain containing 1B
DIO1 deiodinase, iodothyronine, type I
DLK1 delta-like 1 homolog (Drosophila)
DMD dystrophin
DPYD dihydropyrimidine dehydrogenase
ELAVL4 ELAV like neuron-specific RNA binding protein 4
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
ESM1 endothelial cell-specific molecule 1
FAM198B family with sequence similarity 198, member B
FAM69A family with sequence similarity 69, member A
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FLT1 fms-related tyrosine kinase 1
FRY furry homolog (Drosophila)
FSD1 fibronectin type III and SPRY domain containing 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FZD1 frizzled class receptor 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALC galactosylceramidase
GJA1 gap junction protein, alpha 1, 43kDa
GNLY granulysin
GPR18 G protein-coupled receptor 18
GREB1 growth regulation by estrogen in breast cancer 1
H1FX H1 histone family, member X
H2AFV H2A histone family, member V
HACD1 3-hydroxyacyl-CoA dehydratase 1
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOPX HOP homeobox
IFI16 interferon, gamma-inducible protein 16
IFITM1 interferon induced transmembrane protein 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IRF9 interferon regulatory factor 9
ISOC1 isochorismatase domain containing 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCTD12 potassium channel tetramerization domain containing 12
KDR kinase insert domain receptor
KIAA0226L KIAA0226-like
LAMP3 lysosomal-associated membrane protein 3
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
LRMP lymphoid-restricted membrane protein
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MAP3K7CL MAP3K7 C-terminal like
MEF2C myocyte enhancer factor 2C
MEIS2 Meis homeobox 2
MPPED2 metallophosphoesterase domain containing 2
MSMB microseminoprotein, beta-
MTERF3 mitochondrial transcription termination factor 3
MX1 MX dynamin-like GTPase 1
MYBPC1 myosin binding protein C, slow type
NCAM1 neural cell adhesion molecule 1
NCF2 neutrophil cytosolic factor 2
NEB nebulin
NPIPB3 nuclear pore complex interacting protein family, member B3
NR1H2 nuclear receptor subfamily 1, group H, member 2
NREP neuronal regeneration related protein
NRP1 neuropilin 1
P3H2 prolyl 3-hydroxylase 2
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PDE8B phosphodiesterase 8B
PDLIM3 PDZ and LIM domain 3
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PNMAL1 paraneoplastic Ma antigen family-like 1
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCQ protein kinase C, theta
PRPF4B pre-mRNA processing factor 4B
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRK protein tyrosine phosphatase, receptor type, K
RAD21 RAD21 homolog (S. pombe)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RNH1 ribonuclease/angiogenin inhibitor 1
RSU1 Ras suppressor protein 1
RTN1 reticulon 1
RTN2 reticulon 2
S100A1 S100 calcium binding protein A1
S100A8 S100 calcium binding protein A8
SCPEP1 serine carboxypeptidase 1
SEPT6 septin 6
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMC3 structural maintenance of chromosomes 3
SNAP25 synaptosomal-associated protein, 25kDa
SNX10 sorting nexin 10
SOX11 SRY (sex determining region Y)-box 11
SPARCL1 SPARC-like 1 (hevin)
SPON2 spondin 2, extracellular matrix protein
SPRED2 sprouty-related, EVH1 domain containing 2
SRGN serglycin
SSBP2 single-stranded DNA binding protein 2
STMN2 stathmin 2
STON1 stonin 1
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TAL1 T-cell acute lymphocytic leukemia 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCF4 transcription factor 4
TCTA T-cell leukemia translocation altered
TLK2 tousled-like kinase 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM35 transmembrane protein 35
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB3 tribbles pseudokinase 3
TRIM13 tripartite motif containing 13
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
VSNL1 visinin-like 1
VTCN1 V-set domain containing T cell activation inhibitor 1
XAF1 XIAP associated factor 1
XIST X inactive specific transcript (non-protein coding)
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZEB1 zinc finger E-box binding homeobox 1
ZFP36 ZFP36 ring finger protein
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
AGR2 anterior gradient 2
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BZW1 basic leucine zipper and W2 domains 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCL21 chemokine (C-C motif) ligand 21
CDC20 cell division cycle 20
CDKN2A cyclin-dependent kinase inhibitor 2A
CHMP1B charged multivesicular body protein 1B
COL2A1 collagen, type II, alpha 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP1 cysteine-rich protein 1 (intestinal)
CST3 cystatin C
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
CYBA cytochrome b-245, alpha polypeptide
ECI2 enoyl-CoA delta isomerase 2
EI24 etoposide induced 2.4
ENOPH1 enolase-phosphatase 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM222B family with sequence similarity 222, member B
FKBP10 FK506 binding protein 10, 65 kDa
G0S2 G0/G1 switch 2
GMDS GDP-mannose 4,6-dehydratase
GPX3 glutathione peroxidase 3
HES1 hes family bHLH transcription factor 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HN1 hematological and neurological expressed 1
HOMER1 homer scaffolding protein 1
HOXC6 homeobox C6
IGF1R insulin-like growth factor 1 receptor
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KRT10 keratin 10, type I
LAGE3 L antigen family, member 3
LAMC2 laminin, gamma 2
LIF leukemia inhibitory factor
LMNA lamin A/C
LPAR1 lysophosphatidic acid receptor 1
LTBP1 latent transforming growth factor beta binding protein 1
LYPLA1 lysophospholipase I
NFIB nuclear factor I/B
NNMT nicotinamide N-methyltransferase
NPC2 Niemann-Pick disease, type C2
PCM1 pericentriolar material 1
PDGFA platelet-derived growth factor alpha polypeptide
PEBP1 phosphatidylethanolamine binding protein 1
PFKP phosphofructokinase, platelet
PMEPA1 prostate transmembrane protein, androgen induced 1
PON2 paraoxonase 2
PPA2 pyrophosphatase (inorganic) 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKCZ protein kinase C, zeta
PRSS2 protease, serine, 2 (trypsin 2)
PTGES prostaglandin E synthase
RAB13 RAB13, member RAS oncogene family
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPS27L ribosomal protein S27-like
RRAGD Ras-related GTP binding D
S100A10 S100 calcium binding protein A10
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SEPT11 septin 11
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SET SET nuclear proto-oncogene
SFN stratifin
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLIRP SRA stem-loop interacting RNA binding protein
SPINK1 serine peptidase inhibitor, Kazal type 1
SRSF7 serine/arginine-rich splicing factor 7
STOM stomatin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TECR trans-2,3-enoyl-CoA reductase
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOB1 transducer of ERBB2, 1
TOX3 TOX high mobility group box family member 3
TSPAN3 tetraspanin 3
TSPAN8 tetraspanin 8
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
WBSCR22 Williams Beuren syndrome chromosome region 22
ZCCHC24 zinc finger, CCHC domain containing 24