BRD-K87947369_VX-680_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-K87947369_VX-680_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALDOC aldolase C, fructose-bisphosphate
AOX1 aldehyde oxidase 1
AQP3 aquaporin 3 (Gill blood group)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C6ORF62 chromosome 6 open reading frame 62
CCNG2 cyclin G2
CENPE centromere protein E, 312kDa
CES1 carboxylesterase 1
CIT citron rho-interacting serine/threonine kinase
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H3H histone cluster 1, H3h
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
IDI1 isopentenyl-diphosphate delta isomerase 1
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF5B kinesin family member 5B
LDLR low density lipoprotein receptor
MAN1A1 mannosidase, alpha, class 1A, member 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MID1IP1 MID1 interacting protein 1
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NPTX2 neuronal pentraxin II
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLK1 polo-like kinase 1
PPL periplakin
PTEN phosphatase and tensin homolog
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SQLE squalene epoxidase
TKT transketolase
TMSB15A thymosin beta 15a
TSC22D3 TSC22 domain family, member 3
TUBB6 tubulin, beta 6 class V
UBXN7 UBX domain protein 7
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AMIGO2 adhesion molecule with Ig-like domain 2
ANO1 anoctamin 1, calcium activated chloride channel
ANXA4 annexin A4
ARL4C ADP-ribosylation factor-like 4C
ASRGL1 asparaginase like 1
C1QBP complement component 1, q subcomponent binding protein
CD59 CD59 molecule, complement regulatory protein
CFI complement factor I
CTPS1 CTP synthase 1
EFNB2 ephrin-B2
GNLY granulysin
GPX1 glutathione peroxidase 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI16 interferon, gamma-inducible protein 16
IGFBP3 insulin-like growth factor binding protein 3
KCTD12 potassium channel tetramerization domain containing 12
KIAA1551 KIAA1551
MCM6 minichromosome maintenance complex component 6
MMP7 matrix metallopeptidase 7
MRPS35 mitochondrial ribosomal protein S35
MYC v-myc avian myelocytomatosis viral oncogene homolog
NPAS2 neuronal PAS domain protein 2
PCNA proliferating cell nuclear antigen
PPIF peptidylprolyl isomerase F
RCAN1 regulator of calcineurin 1
SCGB2A1 secretoglobin, family 2A, member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SRSF7 serine/arginine-rich splicing factor 7
TMEM109 transmembrane protein 109