BRD-K87909389_alvocidib_SKBR3_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

172 genes differentially expressed following the BRD-K87909389_alvocidib_SKBR3_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABHD2 abhydrolase domain containing 2
ABLIM1 actin binding LIM protein 1
AIF1 allograft inflammatory factor 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
BLNK B-cell linker
C1QTNF3 C1q and tumor necrosis factor related protein 3
CAV2 caveolin 2
CD59 CD59 molecule, complement regulatory protein
CD81 CD81 molecule
CLDN10 claudin 10
COL9A3 collagen, type IX, alpha 3
CSPG4 chondroitin sulfate proteoglycan 4
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
EIF5A eukaryotic translation initiation factor 5A
ERAP1 endoplasmic reticulum aminopeptidase 1
ERLIN2 ER lipid raft associated 2
FABP4 fatty acid binding protein 4, adipocyte
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GLG1 golgi glycoprotein 1
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
HIST1H1C histone cluster 1, H1c
HOXA5 homeobox A5
IFI6 interferon, alpha-inducible protein 6
IFITM3 interferon induced transmembrane protein 3
IL11RA interleukin 11 receptor, alpha
IL17RB interleukin 17 receptor B
INPP5F inositol polyphosphate-5-phosphatase F
LAGE3 L antigen family, member 3
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
LOXL2 lysyl oxidase-like 2
LTBP3 latent transforming growth factor beta binding protein 3
MAOA monoamine oxidase A
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NYNRIN NYN domain and retroviral integrase containing
OAT ornithine aminotransferase
PRAME preferentially expressed antigen in melanoma
PRKCB protein kinase C, beta
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PXDN peroxidasin
RABAC1 Rab acceptor 1 (prenylated)
RNASE6 ribonuclease, RNase A family, k6
RNF130 ring finger protein 130
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SKAP2 src kinase associated phosphoprotein 2
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TKT transketolase
TUBB2A tubulin, beta 2A class IIa
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VIM vimentin
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADO 2-aminoethanethiol (cysteamine) dioxygenase
APOLD1 apolipoprotein L domain containing 1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
AURKA aurora kinase A
BCL10 B-cell CLL/lymphoma 10
BLCAP bladder cancer associated protein
BTG2 BTG family, member 2
CCNF cyclin F
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2AIP CDKN2A interacting protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLP1 cleavage and polyadenylation factor I subunit 1
CSNK1D casein kinase 1, delta
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
EIF1 eukaryotic translation initiation factor 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM60A family with sequence similarity 60, member A
FAS Fas cell surface death receptor
FASTKD5 FAST kinase domains 5
FBXL14 F-box and leucine-rich repeat protein 14
FEM1B fem-1 homolog b (C. elegans)
FZD5 frizzled class receptor 5
GAS1 growth arrest-specific 1
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GATA6 GATA binding protein 6
GRWD1 glutamate-rich WD repeat containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HEXIM1 hexamethylene bis-acetamide inducible 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IL1R2 interleukin 1 receptor, type II
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
KBTBD2 kelch repeat and BTB (POZ) domain containing 2
KLF5 Kruppel-like factor 5 (intestinal)
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MKNK2 MAP kinase interacting serine/threonine kinase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
PDZRN3 PDZ domain containing ring finger 3
PER2 period circadian clock 2
PLAGL2 pleiomorphic adenoma gene-like 2
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PROM1 prominin 1
RBM15 RNA binding motif protein 15
RND3 Rho family GTPase 3
RPP38 ribonuclease P/MRP 38kDa subunit
RUNX3 runt-related transcription factor 3
SERTAD3 SERTA domain containing 3
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLPI secretory leukocyte peptidase inhibitor
SMAD7 SMAD family member 7
SNAP25 synaptosomal-associated protein, 25kDa
SRGN serglycin
TACSTD2 tumor-associated calcium signal transducer 2
TBP TATA box binding protein
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOB1 transducer of ERBB2, 1
TOB2 transducer of ERBB2, 2
TRIB3 tribbles pseudokinase 3
TUBA4A tubulin, alpha 4a
USP1 ubiquitin specific peptidase 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VEGFA vascular endothelial growth factor A
WEE1 WEE1 G2 checkpoint kinase
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZFAND5 zinc finger, AN1-type domain 5
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF217 zinc finger protein 217