BRD-K87909389_alvocidib_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

210 genes differentially expressed following the BRD-K87909389_alvocidib_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACOT13 acyl-CoA thioesterase 13
ADA adenosine deaminase
ADD3 adducin 3 (gamma)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANKRD36B ankyrin repeat domain 36B
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
AUTS2 autism susceptibility candidate 2
BID BH3 interacting domain death agonist
BLNK B-cell linker
C6ORF62 chromosome 6 open reading frame 62
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CADM1 cell adhesion molecule 1
CAPG capping protein (actin filament), gelsolin-like
CAV2 caveolin 2
CCL4 chemokine (C-C motif) ligand 4
CD84 CD84 molecule
CEP70 centrosomal protein 70kDa
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL1A2 collagen, type I, alpha 2
COL6A1 collagen, type VI, alpha 1
CORO1A coronin, actin binding protein, 1A
CTGF connective tissue growth factor
CTSB cathepsin B
CXCL9 chemokine (C-X-C motif) ligand 9
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DFNA5 deafness, autosomal dominant 5
DMD dystrophin
ECHDC1 ethylmalonyl-CoA decarboxylase 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF5A eukaryotic translation initiation factor 5A
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPHA3 EPH receptor A3
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM107A family with sequence similarity 107, member A
FAM8A1 family with sequence similarity 8, member A1
FCHO1 FCH domain only 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FKBP5 FK506 binding protein 5
FN1 fibronectin 1
FOXC1 forkhead box C1
G0S2 G0/G1 switch 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLUL glutamate-ammonia ligase
GOLIM4 golgi integral membrane protein 4
GSN gelsolin
HACD1 3-hydroxyacyl-CoA dehydratase 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HOXA5 homeobox A5
HP haptoglobin
HTRA1 HtrA serine peptidase 1
ICAM1 intercellular adhesion molecule 1
IFITM1 interferon induced transmembrane protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IL2RG interleukin 2 receptor, gamma
ITGAV integrin, alpha V
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITM2A integral membrane protein 2A
KCTD12 potassium channel tetramerization domain containing 12
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF9 Kruppel-like factor 9
LOX lysyl oxidase
LRRC17 leucine rich repeat containing 17
MAOB monoamine oxidase B
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MEF2C myocyte enhancer factor 2C
MGP matrix Gla protein
MMP9 matrix metallopeptidase 9
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
OSMR oncostatin M receptor
PAM peptidylglycine alpha-amidating monooxygenase
PBX3 pre-B-cell leukemia homeobox 3
PER1 period circadian clock 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLBD1 phospholipase B domain containing 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POSTN periostin, osteoblast specific factor
QPRT quinolinate phosphoribosyltransferase
RBP4 retinol binding protein 4, plasma
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCARB2 scavenger receptor class B, member 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SKAP2 src kinase associated phosphoprotein 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SMC1A structural maintenance of chromosomes 1A
SRPR signal recognition particle receptor (docking protein)
SST somatostatin
STC1 stanniocalcin 1
STC2 stanniocalcin 2
STK26 serine/threonine protein kinase 26
TF transferrin
THBS4 thrombospondin 4
TLE2 transducin-like enhancer of split 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPBG trophoblast glycoprotein
TSPAN1 tetraspanin 1
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
VWA5A von Willebrand factor A domain containing 5A
WBP5 WW domain binding protein 5
XIST X inactive specific transcript (non-protein coding)
ZIC1 Zic family member 1
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALCAM activated leukocyte cell adhesion molecule
AQP3 aquaporin 3 (Gill blood group)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BLCAP bladder cancer associated protein
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALML3 calmodulin-like 3
CANT1 calcium activated nucleotidase 1
CASC3 cancer susceptibility candidate 3
CCND1 cyclin D1
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CXCL12 chemokine (C-X-C motif) ligand 12
CYB561 cytochrome b561
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEGS1 delta(4)-desaturase, sphingolipid 1
DHCR24 24-dehydrocholesterol reductase
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EXT1 exostosin glycosyltransferase 1
FAM69A family with sequence similarity 69, member A
GCH1 GTP cyclohydrolase 1
GYG1 glycogenin 1
H2AFZ H2A histone family, member Z
HN1 hematological and neurological expressed 1
HN1L hematological and neurological expressed 1-like
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
INHBB inhibin, beta B
KDM5D lysine (K)-specific demethylase 5D
KIAA0101 KIAA0101
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT23 keratin 23, type I
KRT7 keratin 7, type II
LIMCH1 LIM and calponin homology domains 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MED24 mediator complex subunit 24
MELK maternal embryonic leucine zipper kinase
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP11 matrix metallopeptidase 11
MRPS16 mitochondrial ribosomal protein S16
MSL1 male-specific lethal 1 homolog (Drosophila)
MSMB microseminoprotein, beta-
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit
NOP56 NOP56 ribonucleoprotein
NPY neuropeptide Y
NUP62 nucleoporin 62kDa
NVL nuclear VCP-like
OPN3 opsin 3
ORC1 origin recognition complex, subunit 1
PCNA proliferating cell nuclear antigen
PNP purine nucleoside phosphorylase
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
RAE1 ribonucleic acid export 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SCAND1 SCAN domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SRSF6 serine/arginine-rich splicing factor 6
ST7 suppression of tumorigenicity 7
TACSTD2 tumor-associated calcium signal transducer 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TXLNA taxilin alpha
TXNRD1 thioredoxin reductase 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE3C ubiquitin protein ligase E3C
XBP1 X-box binding protein 1
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF217 zinc finger protein 217