BRD-K87909389_alvocidib_MDAMB231_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-K87909389_alvocidib_MDAMB231_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CAV2 caveolin 2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
COL4A5 collagen, type IV, alpha 5
CXCL5 chemokine (C-X-C motif) ligand 5
EPN2 epsin 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPM6A glycoprotein M6A
GRB14 growth factor receptor-bound protein 14
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0226L KIAA0226-like
LAPTM4B lysosomal protein transmembrane 4 beta
LDOC1 leucine zipper, down-regulated in cancer 1
LPL lipoprotein lipase
LYRM1 LYR motif containing 1
MAOA monoamine oxidase A
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLF1 myeloid leukemia factor 1
NOTCH3 notch 3
NRP1 neuropilin 1
OVGP1 oviductal glycoprotein 1, 120kDa
PECR peroxisomal trans-2-enoyl-CoA reductase
PF4 platelet factor 4
PFKM phosphofructokinase, muscle
PON2 paraoxonase 2
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TCF4 transcription factor 4
TFPI2 tissue factor pathway inhibitor 2
TPGS2 tubulin polyglutamylase complex subunit 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSPAN13 tetraspanin 13

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
APOD apolipoprotein D
ARL4C ADP-ribosylation factor-like 4C
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BCOR BCL6 corepressor
BMP4 bone morphogenetic protein 4
BTG1 B-cell translocation gene 1, anti-proliferative
CBR3 carbonyl reductase 3
CCNE2 cyclin E2
CCNF cyclin F
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDCA4 cell division cycle associated 4
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CELF2 CUGBP, Elav-like family member 2
CHIC2 cysteine-rich hydrophobic domain 2
CHSY1 chondroitin sulfate synthase 1
CSRP2 cysteine and glycine-rich protein 2
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUSP1 dual specificity phosphatase 1
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5 eukaryotic translation initiation factor 5
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FAM13B family with sequence similarity 13, member B
FAS Fas cell surface death receptor
FEM1B fem-1 homolog b (C. elegans)
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FZD10 frizzled class receptor 10
FZD7 frizzled class receptor 7
GAS1 growth arrest-specific 1
GNAS GNAS complex locus
HEXIM1 hexamethylene bis-acetamide inducible 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HOXA1 homeobox A1
IER3 immediate early response 3
IL1R2 interleukin 1 receptor, type II
IRS2 insulin receptor substrate 2
JARID2 jumonji, AT rich interactive domain 2
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
KRT14 keratin 14, type I
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAT2A methionine adenosyltransferase II, alpha
MBP myelin basic protein
MT1H metallothionein 1H
MT1X metallothionein 1X
MTF2 metal response element binding transcription factor 2
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUP153 nucleoporin 153kDa
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RLF rearranged L-myc fusion
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SGK1 serum/glucocorticoid regulated kinase 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD3 SMAD family member 3
SOCS1 suppressor of cytokine signaling 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRSF7 serine/arginine-rich splicing factor 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAGLN transgelin
TGFBR3 transforming growth factor, beta receptor III
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOB2 transducer of ERBB2, 2
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
USP1 ubiquitin specific peptidase 1
VGLL4 vestigial-like family member 4
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2