BRD-K87909389_alvocidib_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

165 genes differentially expressed following the BRD-K87909389_alvocidib_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AAMDC adipogenesis associated, Mth938 domain containing
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADA adenosine deaminase
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AIF1 allograft inflammatory factor 1
ALOX5 arachidonate 5-lipoxygenase
ASPN asporin
C7 complement component 7
CD3D CD3d molecule, delta (CD3-TCR complex)
CD48 CD48 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFD complement factor D (adipsin)
CFH complement factor H
CFI complement factor I
CKB creatine kinase, brain
CLU clusterin
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
CSF1R colony stimulating factor 1 receptor
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DHRS2 dehydrogenase/reductase (SDR family) member 2
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EGR1 early growth response 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM107A family with sequence similarity 107, member A
FOXF1 forkhead box F1
FRY furry homolog (Drosophila)
GADD45B growth arrest and DNA-damage-inducible, beta
GPM6A glycoprotein M6A
HCAR3 hydroxycarboxylic acid receptor 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGN5 high mobility group nucleosome binding domain 5
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IL2RG interleukin 2 receptor, gamma
ITGAV integrin, alpha V
ITM2A integral membrane protein 2A
JAM3 junctional adhesion molecule 3
LDB2 LIM domain binding 2
MDFIC MyoD family inhibitor domain containing
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEF2C myocyte enhancer factor 2C
MT1F metallothionein 1F
MT1M metallothionein 1M
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
NEFL neurofilament, light polypeptide
NTS neurotensin
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLVAP plasmalemma vesicle associated protein
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCQ protein kinase C, theta
RGS5 regulator of G-protein signaling 5
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SDC2 syndecan 2
SEPT6 septin 6
SEPW1 selenoprotein W, 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SNAP25 synaptosomal-associated protein, 25kDa
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
SSBP2 single-stranded DNA binding protein 2
STAB1 stabilin 1
STC1 stanniocalcin 1
TCF4 transcription factor 4
TGFB1 transforming growth factor, beta 1
TGFBR3 transforming growth factor, beta receptor III
TMSB15A thymosin beta 15a
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
TYROBP TYRO protein tyrosine kinase binding protein
WFDC1 WAP four-disulfide core domain 1
XIST X inactive specific transcript (non-protein coding)
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
AHNAK AHNAK nucleoprotein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AREG amphiregulin
ARF6 ADP-ribosylation factor 6
ARID4B AT rich interactive domain 4B (RBP1-like)
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BIRC2 baculoviral IAP repeat containing 2
BUB3 BUB3 mitotic checkpoint protein
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CLTA clathrin, light chain A
CST1 cystatin SN
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMBP dynamin binding protein
DPEP1 dipeptidase 1 (renal)
DUSP6 dual specificity phosphatase 6
EIF4E eukaryotic translation initiation factor 4E
EIF6 eukaryotic translation initiation factor 6
EREG epiregulin
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GCH1 GTP cyclohydrolase 1
H1F0 H1 histone family, member 0
IGKV1-5 immunoglobulin kappa variable 1-5
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
ITGB1BP1 integrin beta 1 binding protein 1
KEAP1 kelch-like ECH-associated protein 1
KLF5 Kruppel-like factor 5 (intestinal)
KLK6 kallikrein-related peptidase 6
KRT14 keratin 14, type I
KRT16 keratin 16, type I
LASP1 LIM and SH3 protein 1
LBR lamin B receptor
MACF1 microtubule-actin crosslinking factor 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCM3 minichromosome maintenance complex component 3
MELK maternal embryonic leucine zipper kinase
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2 notch 2
NUP62 nucleoporin 62kDa
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
PLK2 polo-like kinase 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
RNPS1 RNA binding protein S1, serine-rich domain
RRM2 ribonucleotide reductase M2
S100A12 S100 calcium binding protein A12
S100A7 S100 calcium binding protein A7
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC43A3 solute carrier family 43, member 3
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY2 sprouty homolog 2 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRAM2 translocation associated membrane protein 2
TRIM29 tripartite motif containing 29
TSPYL5 TSPY-like 5
TUBA4A tubulin, alpha 4a
TXLNA taxilin alpha
UGCG UDP-glucose ceramide glucosyltransferase
USP22 ubiquitin specific peptidase 22
VCAN versican