BRD-K87909389_alvocidib_MCF7_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K87909389_alvocidib_MCF7_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACP5 acid phosphatase 5, tartrate resistant
ADGRE5 adhesion G protein-coupled receptor E5
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AP2B1 adaptor-related protein complex 2, beta 1 subunit
BCHE butyrylcholinesterase
C2CD2 C2 calcium-dependent domain containing 2
C7 complement component 7
CCL20 chemokine (C-C motif) ligand 20
CXCL2 chemokine (C-X-C motif) ligand 2
CYBRD1 cytochrome b reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EGFR epidermal growth factor receptor
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
FAM171A1 family with sequence similarity 171, member A1
FOXO4 forkhead box O4
GSTP1 glutathione S-transferase pi 1
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITM2A integral membrane protein 2A
MARCO macrophage receptor with collagenous structure
MDFIC MyoD family inhibitor domain containing
MMP1 matrix metallopeptidase 1
MOK MOK protein kinase
NT5E 5'-nucleotidase, ecto (CD73)
PRAME preferentially expressed antigen in melanoma
RGS2 regulator of G-protein signaling 2
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SORD sorbitol dehydrogenase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
TFPI2 tissue factor pathway inhibitor 2
TSPAN8 tetraspanin 8
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
ADM adrenomedullin
ARID4B AT rich interactive domain 4B (RBP1-like)
AURKA aurora kinase A
BAG5 BCL2-associated athanogene 5
BCL6 B-cell CLL/lymphoma 6
CALML5 calmodulin-like 5
CCNE2 cyclin E2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CLU clusterin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF5 eukaryotic translation initiation factor 5
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM208B family with sequence similarity 208, member B
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GATA3 GATA binding protein 3
IER2 immediate early response 2
IER5 immediate early response 5
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KRT23 keratin 23, type I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MMP7 matrix metallopeptidase 7
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
PARP2 poly (ADP-ribose) polymerase 2
PDE4B phosphodiesterase 4B, cAMP-specific
PLK2 polo-like kinase 2
PMP22 peripheral myelin protein 22
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
RRM2 ribonucleotide reductase M2
SCGB2A2 secretoglobin, family 2A, member 2
SMAD3 SMAD family member 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
USP1 ubiquitin specific peptidase 1
WEE1 WEE1 G2 checkpoint kinase
XIST X inactive specific transcript (non-protein coding)
ZEB1 zinc finger E-box binding homeobox 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF217 zinc finger protein 217