BRD-K87909389_alvocidib_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

105 genes differentially expressed following the BRD-K87909389_alvocidib_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AQP1 aquaporin 1 (Colton blood group)
BCHE butyrylcholinesterase
CD34 CD34 molecule
CD93 CD93 molecule
CHRDL1 chordin-like 1
CLEC2B C-type lectin domain family 2, member B
CP ceruloplasmin (ferroxidase)
CRTAP cartilage associated protein
CRYAB crystallin, alpha B
CYR61 cysteine-rich, angiogenic inducer, 61
DKK3 dickkopf WNT signaling pathway inhibitor 3
ECM1 extracellular matrix protein 1
EFNB2 ephrin-B2
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EXPH5 exophilin 5
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
FOXF1 forkhead box F1
FRY furry homolog (Drosophila)
G0S2 G0/G1 switch 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPM6A glycoprotein M6A
GPX3 glutathione peroxidase 3
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
KLF9 Kruppel-like factor 9
LDHB lactate dehydrogenase B
LPL lipoprotein lipase
MAOA monoamine oxidase A
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEF2C myocyte enhancer factor 2C
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MSN moesin
MXRA7 matrix-remodelling associated 7
NDRG2 NDRG family member 2
NPR3 natriuretic peptide receptor 3
NR1D2 nuclear receptor subfamily 1, group D, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PDLIM3 PDZ and LIM domain 3
PDZD2 PDZ domain containing 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PLVAP plasmalemma vesicle associated protein
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RABGAP1L RAB GTPase activating protein 1-like
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORBS1 sorbin and SH3 domain containing 1
SOX17 SRY (sex determining region Y)-box 17
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
STC1 stanniocalcin 1
TFPI2 tissue factor pathway inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TSPAN12 tetraspanin 12
TSPAN7 tetraspanin 7
TYROBP TYRO protein tyrosine kinase binding protein
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAMBI BMP and activin membrane-bound inhibitor
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GREB1 growth regulation by estrogen in breast cancer 1
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IVNS1ABP influenza virus NS1A binding protein
KLHL21 kelch-like family member 21
MARCKS myristoylated alanine-rich protein kinase C substrate
NET1 neuroepithelial cell transforming 1
NPY1R neuropeptide Y receptor Y1
RAE1 ribonucleic acid export 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SOX4 SRY (sex determining region Y)-box 4
TACSTD2 tumor-associated calcium signal transducer 2
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
TFRC transferrin receptor
TXLNA taxilin alpha
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)