BRD-K87909389_alvocidib_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K87909389_alvocidib_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
ARHGAP29 Rho GTPase activating protein 29
BTG2 BTG family, member 2
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
COL4A5 collagen, type IV, alpha 5
CTSS cathepsin S
DHRS2 dehydrogenase/reductase (SDR family) member 2
EIF5A eukaryotic translation initiation factor 5A
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
GGT1 gamma-glutamyltransferase 1
GPX3 glutathione peroxidase 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOPX HOP homeobox
IFRD2 interferon-related developmental regulator 2
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KRT7 keratin 7, type II
LIMCH1 LIM and calponin homology domains 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MT1E metallothionein 1E
MT1F metallothionein 1F
NMU neuromedin U
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPR1 nuclear protein, transcriptional regulator, 1
OPHN1 oligophrenin 1
PAX8 paired box 8
PDE8B phosphodiesterase 8B
PEG3 paternally expressed 3
PTN pleiotrophin
PVALB parvalbumin
REG1A regenerating islet-derived 1 alpha
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SESN1 sestrin 1
SFRP1 secreted frizzled-related protein 1
SPATA20 spermatogenesis associated 20
SRSF11 serine/arginine-rich splicing factor 11
TBX3 T-box 3
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TSPAN1 tetraspanin 1
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
CDC25A cell division cycle 25A
CENPN centromere protein N
CENPU centromere protein U
CNOT7 CCR4-NOT transcription complex, subunit 7
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FGFR2 fibroblast growth factor receptor 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA2 heat shock 70kDa protein 2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGKV1-5 immunoglobulin kappa variable 1-5
JCHAIN joining chain of multimeric IgA and IgM
KRT23 keratin 23, type I
LAPTM4B lysosomal protein transmembrane 4 beta
MUC5B mucin 5B, oligomeric mucus/gel-forming
MX1 MX dynamin-like GTPase 1
MYB v-myb avian myeloblastosis viral oncogene homolog
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPTX2 neuronal pentraxin II
NPY1R neuropeptide Y receptor Y1
ORM1 orosomucoid 1
PCM1 pericentriolar material 1
RRM1 ribonucleotide reductase M1
SCGB1D2 secretoglobin, family 1D, member 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STMN1 stathmin 1
TMPO thymopoietin
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
UBE2C ubiquitin-conjugating enzyme E2C