BRD-K87909389_alvocidib_MCF10A_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

188 genes differentially expressed following the BRD-K87909389_alvocidib_MCF10A_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
AES amino-terminal enhancer of split
AFP alpha-fetoprotein
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
BEX1 brain expressed, X-linked 1
BID BH3 interacting domain death agonist
CLEC11A C-type lectin domain family 11, member A
COL6A1 collagen, type VI, alpha 1
COL6A3 collagen, type VI, alpha 3
CSTB cystatin B (stefin B)
DLK1 delta-like 1 homolog (Drosophila)
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FAM134B family with sequence similarity 134, member B
FAM63A family with sequence similarity 63, member A
GPC1 glypican 1
HACD1 3-hydroxyacyl-CoA dehydratase 1
HBE1 hemoglobin, epsilon 1
HDLBP high density lipoprotein binding protein
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
ITM2A integral membrane protein 2A
KIAA0930 KIAA0930
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMA1 LIM domain and actin binding 1
LRRC15 leucine rich repeat containing 15
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGED1 melanoma antigen family D1
MAOA monoamine oxidase A
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP9 matrix metallopeptidase 9
MN1 meningioma (disrupted in balanced translocation) 1
NDN necdin, melanoma antigen (MAGE) family member
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NID2 nidogen 2 (osteonidogen)
NT5DC2 5'-nucleotidase domain containing 2
PEG3 paternally expressed 3
PI3 peptidase inhibitor 3, skin-derived
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
RAB25 RAB25, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIDT2 SID1 transmembrane family, member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SORD sorbitol dehydrogenase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STK39 serine threonine kinase 39
STS steroid sulfatase (microsomal), isozyme S
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TFF1 trefoil factor 1
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPD52L1 tumor protein D52-like 1
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADRB2 adrenoceptor beta 2, surface
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
BAMBI BMP and activin membrane-bound inhibitor
BTG1 B-cell translocation gene 1, anti-proliferative
C1QB complement component 1, q subcomponent, B chain
C21ORF91 chromosome 21 open reading frame 91
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCNF cyclin F
CD24 CD24 molecule
CD8A CD8a molecule
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN2AIP CDKN2A interacting protein
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CGRRF1 cell growth regulator with ring finger domain 1
CLEC2B C-type lectin domain family 2, member B
CLK4 CDC-like kinase 4
CLU clusterin
CXCL11 chemokine (C-X-C motif) ligand 11
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EED embryonic ectoderm development
EIF5 eukaryotic translation initiation factor 5
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FGFR1 fibroblast growth factor receptor 1
FKBP5 FK506 binding protein 5
FOXO3 forkhead box O3
GCH1 GTP cyclohydrolase 1
GNLY granulysin
GPR171 G protein-coupled receptor 171
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
HAUS3 HAUS augmin-like complex, subunit 3
HOXA5 homeobox A5
IDO1 indoleamine 2,3-dioxygenase 1
IER2 immediate early response 2
IER3 immediate early response 3
IFI44 interferon-induced protein 44
IFRD1 interferon-related developmental regulator 1
IL18 interleukin 18
IL1R1 interleukin 1 receptor, type I
JADE2 jade family PHD finger 2
KIAA0485 uncharacterized LOC57235
KLF5 Kruppel-like factor 5 (intestinal)
KLF9 Kruppel-like factor 9
KRT5 keratin 5, type II
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MCTP1 multiple C2 domains, transmembrane 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
PALMD palmdelphin
PDGFA platelet-derived growth factor alpha polypeptide
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGAP1 post-GPI attachment to proteins 1
PLIN2 perilipin 2
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
RAD9A RAD9 homolog A (S. pombe)
RBM15 RNA binding motif protein 15
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RND3 Rho family GTPase 3
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RYBP RING1 and YY1 binding protein
SAP30 Sin3A-associated protein, 30kDa
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN1 sestrin 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD3 SMAD family member 3
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SRGN serglycin
SRSF11 serine/arginine-rich splicing factor 11
SRSF7 serine/arginine-rich splicing factor 7
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
TKTL1 transketolase-like 1
TMPRSS3 transmembrane protease, serine 3
TP53BP2 tumor protein p53 binding protein 2
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
USP1 ubiquitin specific peptidase 1
VTCN1 V-set domain containing T cell activation inhibitor 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZBTB16 zinc finger and BTB domain containing 16
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF232 zinc finger protein 232