BRD-K87909389_alvocidib_MCF10A_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

216 genes differentially expressed following the BRD-K87909389_alvocidib_MCF10A_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ACKR3 atypical chemokine receptor 3
ACTG2 actin, gamma 2, smooth muscle, enteric
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
AIF1 allograft inflammatory factor 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA4 annexin A4
AQP1 aquaporin 1 (Colton blood group)
BASP1 brain abundant, membrane attached signal protein 1
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C1R complement component 1, r subcomponent
CALB1 calbindin 1, 28kDa
CD300A CD300a molecule
CD53 CD53 molecule
CELF2 CUGBP, Elav-like family member 2
CFD complement factor D (adipsin)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLCA2 chloride channel accessory 2
CLEC3B C-type lectin domain family 3, member B
COLEC12 collectin sub-family member 12
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
CYBB cytochrome b-245, beta polypeptide
DKK3 dickkopf WNT signaling pathway inhibitor 3
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FAM127A family with sequence similarity 127, member A
FBLN1 fibulin 1
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
GPM6B glycoprotein M6B
GULP1 GULP, engulfment adaptor PTB domain containing 1
H2BFS H2B histone family, member S (pseudogene)
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HMOX1 heme oxygenase 1
IFNGR1 interferon gamma receptor 1
ITFG1 integrin alpha FG-GAP repeat containing 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAG1 jagged 1
KRT6A keratin 6A, type II
LAPTM5 lysosomal protein transmembrane 5
LST1 leukocyte specific transcript 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MFAP5 microfibrillar associated protein 5
MMD monocyte to macrophage differentiation-associated
MMP7 matrix metallopeptidase 7
MYH11 myosin, heavy chain 11, smooth muscle
NCF2 neutrophil cytosolic factor 2
NDRG1 N-myc downstream regulated 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OSR2 odd-skipped related transciption factor 2
OXSR1 oxidative stress responsive 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDGFD platelet derived growth factor D
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDZK1IP1 PDZK1 interacting protein 1
PEG10 paternally expressed 10
PHF20 PHD finger protein 20
PI3 peptidase inhibitor 3, skin-derived
PLXNB2 plexin B2
PPAP2B phosphatidic acid phosphatase type 2B
PPL periplakin
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRC protein tyrosine phosphatase, receptor type, C
PYCARD PYD and CARD domain containing
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPL31 ribosomal protein L31
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SGCE sarcoglycan, epsilon
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SPINT1 serine peptidase inhibitor, Kunitz type 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM45A transmembrane protein 45A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNIP1 TNFAIP3 interacting protein 1
TNS3 tensin 3
TP53I3 tumor protein p53 inducible protein 3
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TUBB2B tubulin, beta 2B class IIb
TXNIP thioredoxin interacting protein
WISP2 WNT1 inducible signaling pathway protein 2
ZFP36L2 ZFP36 ring finger protein-like 2
ZIC1 Zic family member 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AMD1 adenosylmethionine decarboxylase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA2 annexin A2
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ATF5 activating transcription factor 5
AURKB aurora kinase B
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BMI1 BMI1 proto-oncogene, polycomb ring finger
CACYBP calcyclin binding protein
CCK cholecystokinin
CCNA2 cyclin A2
CCNF cyclin F
CD81 CD81 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHMP4A charged multivesicular body protein 4A
CKS2 CDC28 protein kinase regulatory subunit 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
DBF4 DBF4 zinc finger
DDAH1 dimethylarginine dimethylaminohydrolase 1
DEGS1 delta(4)-desaturase, sphingolipid 1
DLC1 DLC1 Rho GTPase activating protein
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP2 dual specificity phosphatase 2
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ENOSF1 enolase superfamily member 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAS GNAS complex locus
GTPBP8 GTP-binding protein 8 (putative)
GTSE1 G-2 and S-phase expressed 1
GZMK granzyme K (granzyme 3; tryptase II)
HACD3 3-hydroxyacyl-CoA dehydratase 3
HBEGF heparin-binding EGF-like growth factor
HIST1H4C histone cluster 1, H4c
HMGB1 high mobility group box 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP5 insulin-like growth factor binding protein 5
JMJD6 jumonji domain containing 6
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MMP9 matrix metallopeptidase 9
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAP1L1 nucleosome assembly protein 1-like 1
NCAPG non-SMC condensin I complex, subunit G
NPY neuropeptide Y
NR2F1 nuclear receptor subfamily 2, group F, member 1
PHACTR2 phosphatase and actin regulator 2
PHLDA2 pleckstrin homology-like domain, family A, member 2
PNN pinin, desmosome associated protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRDX2 peroxiredoxin 2
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSPH phosphoserine phosphatase
RANBP1 RAN binding protein 1
RBPMS RNA binding protein with multiple splicing
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCML1 sex comb on midleg-like 1 (Drosophila)
SEPT11 septin 11
SHCBP1 SHC SH2-domain binding protein 1
SKP1 S-phase kinase-associated protein 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SMC4 structural maintenance of chromosomes 4
SNRPG small nuclear ribonucleoprotein polypeptide G
SORD sorbitol dehydrogenase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF3 serine/arginine-rich splicing factor 3
STMN1 stathmin 1
SUB1 SUB1 homolog (S. cerevisiae)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TDO2 tryptophan 2,3-dioxygenase
TESC tescalcin
TIPIN TIMELESS interacting protein
TMEM47 transmembrane protein 47
TMPO thymopoietin
TSPAN13 tetraspanin 13
TWF1 twinfilin actin binding protein 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
USP1 ubiquitin specific peptidase 1
WEE1 WEE1 G2 checkpoint kinase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZWILCH zwilch kinetochore protein