BRD-K87909389_alvocidib_LNCAP_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

228 genes differentially expressed following the BRD-K87909389_alvocidib_LNCAP_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AAMDC adipogenesis associated, Mth938 domain containing
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANPEP alanyl (membrane) aminopeptidase
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ASMTL acetylserotonin O-methyltransferase-like
BCL2L1 BCL2-like 1
BSG basigin (Ok blood group)
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CD46 CD46 molecule, complement regulatory protein
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CERS2 ceramide synthase 2
CLU clusterin
COCH cochlin
COG5 component of oligomeric golgi complex 5
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CPB1 carboxypeptidase B1 (tissue)
CST7 cystatin F (leukocystatin)
CSTA cystatin A (stefin A)
CTTN cortactin
CYB5A cytochrome b5 type A (microsomal)
CYBRD1 cytochrome b reductase 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DEFB1 defensin, beta 1
EGR1 early growth response 1
EGR2 early growth response 2
ENO2 enolase 2 (gamma, neuronal)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENSA endosulfine alpha
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM149A family with sequence similarity 149, member A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GPM6A glycoprotein M6A
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPX3 glutathione peroxidase 3
GSN gelsolin
GSTP1 glutathione S-transferase pi 1
GUSBP3 glucuronidase, beta pseudogene 3
HBB hemoglobin, beta
HBE1 hemoglobin, epsilon 1
HRSP12 heat-responsive protein 12
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
IL2RB interleukin 2 receptor, beta
ISG15 ISG15 ubiquitin-like modifier
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LAMP3 lysosomal-associated membrane protein 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOX lysyl oxidase
LRRC17 leucine rich repeat containing 17
LTA4H leukotriene A4 hydrolase
LYN LYN proto-oncogene, Src family tyrosine kinase
LYZ lysozyme
MAN2B1 mannosidase, alpha, class 2B, member 1
METRN meteorin, glial cell differentiation regulator
MMP1 matrix metallopeptidase 1
MSRB1 methionine sulfoxide reductase B1
NDRG1 N-myc downstream regulated 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
NTS neurotensin
NUCB1 nucleobindin 1
NYNRIN NYN domain and retroviral integrase containing
OSBPL10 oxysterol binding protein-like 10
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRF1 perforin 1 (pore forming protein)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS21 protease, serine, 21 (testisin)
PTN pleiotrophin
RGCC regulator of cell cycle
RUNX3 runt-related transcription factor 3
S100A10 S100 calcium binding protein A10
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SFTPC surfactant protein C
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPP1 secreted phosphoprotein 1
SYNGR3 synaptogyrin 3
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP3 TIMP metallopeptidase inhibitor 3
TMBIM6 transmembrane BAX inhibitor motif containing 6
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPM4 tropomyosin 4
TPP1 tripeptidyl peptidase I
TYROBP TYRO protein tyrosine kinase binding protein
WFDC2 WAP four-disulfide core domain 2
XCL1 chemokine (C motif) ligand 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
ASS1 argininosuccinate synthase 1
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
C14ORF132 chromosome 14 open reading frame 132
C1ORF116 chromosome 1 open reading frame 116
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS2 CDC28 protein kinase regulatory subunit 2
COL16A1 collagen, type XVI, alpha 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSNK1D casein kinase 1, delta
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDIT4 DNA-damage-inducible transcript 4
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUOX2 dual oxidase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FCGBP Fc fragment of IgG binding protein
FOXO3 forkhead box O3
GAS1 growth arrest-specific 1
GATA2 GATA binding protein 2
GEMIN4 gem (nuclear organelle) associated protein 4
GLOD4 glyoxalase domain containing 4
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GRB10 growth factor receptor-bound protein 10
GSPT2 G1 to S phase transition 2
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGF1R insulin-like growth factor 1 receptor
ILF3 interleukin enhancer binding factor 3, 90kDa
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
KEAP1 kelch-like ECH-associated protein 1
KIF20A kinesin family member 20A
KRT7 keratin 7, type II
LIMCH1 LIM and calponin homology domains 1
LXN latexin
MAK16 MAK16 homolog (S. cerevisiae)
MB myoglobin
MED1 mediator complex subunit 1
MED17 mediator complex subunit 17
METTL3 methyltransferase like 3
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP3 matrix metallopeptidase 3
MOB4 MOB family member 4, phocein
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDC80 NDC80 kinetochore complex component
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NKX3-1 NK3 homeobox 1
NOP56 NOP56 ribonucleoprotein
NUP85 nucleoporin 85kDa
NXF1 nuclear RNA export factor 1
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PDLIM4 PDZ and LIM domain 4
PDZRN3 PDZ domain containing ring finger 3
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
PROM1 prominin 1
PRPF4B pre-mRNA processing factor 4B
PSD3 pleckstrin and Sec7 domain containing 3
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
RAB14 RAB14, member RAS oncogene family
RANBP2 RAN binding protein 2
RNMT RNA (guanine-7-) methyltransferase
RNPS1 RNA binding protein S1, serine-rich domain
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
SCAND1 SCAN domain containing 1
SIK1 salt-inducible kinase 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD1 SMAD family member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBP TATA box binding protein
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAM transcription factor A, mitochondrial
THUMPD1 THUMP domain containing 1
TMEM70 transmembrane protein 70
TMEM97 transmembrane protein 97
TMX4 thioredoxin-related transmembrane protein 4
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOB1 transducer of ERBB2, 1
TPBG trophoblast glycoprotein
TSPYL5 TSPY-like 5
TXLNA taxilin alpha
USP22 ubiquitin specific peptidase 22
USP3 ubiquitin specific peptidase 3
VGLL4 vestigial-like family member 4
WTAP Wilms tumor 1 associated protein
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36L2 ZFP36 ring finger protein-like 2
ZHX2 zinc fingers and homeoboxes 2