BRD-K87909389_alvocidib_LNCAP_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

379 genes differentially expressed following the BRD-K87909389_alvocidib_LNCAP_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ACTN1 actinin, alpha 1
ADRB2 adrenoceptor beta 2, surface
AIF1 allograft inflammatory factor 1
AMPD2 adenosine monophosphate deaminase 2
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD47 CD47 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CELF2 CUGBP, Elav-like family member 2
CFB complement factor B
COL4A5 collagen, type IV, alpha 5
CSNK1D casein kinase 1, delta
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL6 chemokine (C-X-C motif) ligand 6
CYB5A cytochrome b5 type A (microsomal)
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAPK3 death-associated protein kinase 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DMPK dystrophia myotonica-protein kinase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EFNA1 ephrin-A1
ELF1 E74-like factor 1 (ets domain transcription factor)
EMX2 empty spiracles homeobox 2
FAM110B family with sequence similarity 110, member B
FAS Fas cell surface death receptor
FGG fibrinogen gamma chain
FOLR1 folate receptor 1 (adult)
FOSL2 FOS-like antigen 2
FTH1 ferritin, heavy polypeptide 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GADD45A growth arrest and DNA-damage-inducible, alpha
GBP1 guanylate binding protein 1, interferon-inducible
GLUL glutamate-ammonia ligase
GNPDA1 glucosamine-6-phosphate deaminase 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IFNGR1 interferon gamma receptor 1
IGFBP3 insulin-like growth factor binding protein 3
IL32 interleukin 32
ILK integrin-linked kinase
IRF1 interferon regulatory factor 1
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KDM4B lysine (K)-specific demethylase 4B
KDM6A lysine (K)-specific demethylase 6A
KLF10 Kruppel-like factor 10
KLF11 Kruppel-like factor 11
KLF4 Kruppel-like factor 4 (gut)
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS8 lectin, galactoside-binding, soluble, 8
LINC00094 long intergenic non-protein coding RNA 94
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LTB lymphotoxin beta (TNF superfamily, member 3)
LYPD1 LY6/PLAUR domain containing 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN2B1 mannosidase, alpha, class 2B, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MIR22HG MIR22 host gene
MMP10 matrix metallopeptidase 10
MMP7 matrix metallopeptidase 7
MVP major vault protein
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRCAM neuronal cell adhesion molecule
OPN3 opsin 3
OSBPL2 oxysterol binding protein-like 2
PDZK1IP1 PDZK1 interacting protein 1
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PGC progastricsin (pepsinogen C)
PLK2 polo-like kinase 2
PLXNB2 plexin B2
PTPRE protein tyrosine phosphatase, receptor type, E
PXDN peroxidasin
QPRT quinolinate phosphoribosyltransferase
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RALGDS ral guanine nucleotide dissociation stimulator
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF44 ring finger protein 44
RPL31 ribosomal protein L31
RRAGC Ras-related GTP binding C
RSL1D1 ribosomal L1 domain containing 1
RUNX3 runt-related transcription factor 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SDCBP syndecan binding protein (syntenin)
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGCE sarcoglycan, epsilon
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOD2 superoxide dismutase 2, mitochondrial
SPINK1 serine peptidase inhibitor, Kazal type 1
SQSTM1 sequestosome 1
SST somatostatin
TFE3 transcription factor binding to IGHM enhancer 3
TIGAR TP53 induced glycolysis regulatory phosphatase
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNIP1 TNFAIP3 interacting protein 1
TPP1 tripeptidyl peptidase I
TRAF3IP2 TRAF3 interacting protein 2
TRIM22 tripartite motif containing 22
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VCAM1 vascular cell adhesion molecule 1
VGLL4 vestigial-like family member 4
WT1 Wilms tumor 1
YBX3 Y box binding protein 3
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADGRG6 adhesion G protein-coupled receptor G6
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADI1 acireductone dioxygenase 1
AGA aspartylglucosaminidase
AGR2 anterior gradient 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA1 annexin A1
APOD apolipoprotein D
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
ATF5 activating transcription factor 5
AURKB aurora kinase B
BCHE butyrylcholinesterase
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BLMH bleomycin hydrolase
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C2CD5 C2 calcium-dependent domain containing 5
C3ORF14 chromosome 3 open reading frame 14
CA12 carbonic anhydrase XII
CALR calreticulin
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE2 cyclin E2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CDSN corneodesmosin
CDT1 chromatin licensing and DNA replication factor 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHMP4A charged multivesicular body protein 4A
CIT citron rho-interacting serine/threonine kinase
COL14A1 collagen, type XIV, alpha 1
COL5A2 collagen, type V, alpha 2
CYBA cytochrome b-245, alpha polypeptide
DCN decorin
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT4 DNA-damage-inducible transcript 4
DEPDC1 DEP domain containing 1
DEPTOR DEP domain containing MTOR-interacting protein
DHFR dihydrofolate reductase
DHTKD1 dehydrogenase E1 and transketolase domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMP2 epithelial membrane protein 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ETV1 ets variant 1
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM129A family with sequence similarity 129, member A
FAM64A family with sequence similarity 64, member A
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
FLG filaggrin
FOXM1 forkhead box M1
FXYD3 FXYD domain containing ion transport regulator 3
GARS glycyl-tRNA synthetase
GATA3 GATA binding protein 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GPM6B glycoprotein M6B
GRAMD1C GRAM domain containing 1C
GRB14 growth factor receptor-bound protein 14
GTPBP8 GTP-binding protein 8 (putative)
GTSE1 G-2 and S-phase expressed 1
H2AFV H2A histone family, member V
H2AFX H2A histone family, member X
HAL histidine ammonia-lyase
HAPLN1 hyaluronan and proteoglycan link protein 1
HAT1 histone acetyltransferase 1
HEBP2 heme binding protein 2
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOMER2 homer scaffolding protein 2
HOXB7 homeobox B7
HOXC10 homeobox C10
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IL13RA2 interleukin 13 receptor, alpha 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KIAA1598
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KIFC1 kinesin family member C1
LEPR leptin receptor
LMNB1 lamin B1
LRRC17 leucine rich repeat containing 17
LUM lumican
MAB21L2 mab-21-like 2 (C. elegans)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MATN2 matrilin 2
MBP myelin basic protein
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MFAP3L microfibrillar-associated protein 3-like
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
MSH2 mutS homolog 2
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYH11 myosin, heavy chain 11, smooth muscle
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NPR3 natriuretic peptide receptor 3
NQO1 NAD(P)H dehydrogenase, quinone 1
NRN1 neuritin 1
NTS neurotensin
NUP93 nucleoporin 93kDa
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PALMD palmdelphin
PBK PDZ binding kinase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLIN1 perilipin 1
PLK1 polo-like kinase 1
PLS1 plastin 1
PLS3 plastin 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRC1 protein regulator of cytokinesis 1
PRDX4 peroxiredoxin 4
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSAT1 phosphoserine aminotransferase 1
PSIP1 PC4 and SFRS1 interacting protein 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
RNASEH2A ribonuclease H2, subunit A
RRM2 ribonucleotide reductase M2
SCCPDH saccharopine dehydrogenase (putative)
SCRG1 stimulator of chondrogenesis 1
SEPW1 selenoprotein W, 1
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SMAGP small cell adhesion glycoprotein
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SMS spermine synthase
SORD sorbitol dehydrogenase
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SSFA2 sperm specific antigen 2
STMN1 stathmin 1
SYNE2 spectrin repeat containing, nuclear envelope 2
SYNM synemin, intermediate filament protein
TACC3 transforming, acidic coiled-coil containing protein 3
TFF3 trefoil factor 3 (intestinal)
THBS2 thrombospondin 2
TIMELESS timeless circadian clock
TMPO thymopoietin
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRMT5 tRNA methyltransferase 5
TROAP trophinin associated protein
TSPAN13 tetraspanin 13
TTK TTK protein kinase
TUBB tubulin, beta class I
TXN thioredoxin
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZBTB20 zinc finger and BTB domain containing 20
ZDHHC6 zinc finger, DHHC-type containing 6
ZWILCH zwilch kinetochore protein