BRD-K87909389_alvocidib_HS578T_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

164 genes differentially expressed following the BRD-K87909389_alvocidib_HS578T_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
APLP2 amyloid beta (A4) precursor-like protein 2
CD36 CD36 molecule (thrombospondin receptor)
CFB complement factor B
CGA glycoprotein hormones, alpha polypeptide
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLU clusterin
COL3A1 collagen, type III, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CYFIP1 cytoplasmic FMR1 interacting protein 1
DCN decorin
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
FBLN1 fibulin 1
FBN2 fibrillin 2
FOLR1 folate receptor 1 (adult)
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GLG1 golgi glycoprotein 1
GM2A GM2 ganglioside activator
GNB5 guanine nucleotide binding protein (G protein), beta 5
GPX3 glutathione peroxidase 3
GRIA2 glutamate receptor, ionotropic, AMPA 2
IDO1 indoleamine 2,3-dioxygenase 1
IFITM3 interferon induced transmembrane protein 3
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LPL lipoprotein lipase
LRRC16A leucine rich repeat containing 16A
LTF lactotransferrin
MAOA monoamine oxidase A
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP10 matrix metallopeptidase 10
MMP9 matrix metallopeptidase 9
NPTN neuroplastin
NTS neurotensin
OLFM1 olfactomedin 1
OSBPL10 oxysterol binding protein-like 10
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PAX8 paired box 8
RTN1 reticulon 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFTPB surfactant protein B
SFTPC surfactant protein C
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLPI secretory leukocyte peptidase inhibitor
SPON1 spondin 1, extracellular matrix protein
SPP1 secreted phosphoprotein 1
SRPX sushi-repeat containing protein, X-linked
STXBP1 syntaxin binding protein 1
TFPI2 tissue factor pathway inhibitor 2
TMEM47 transmembrane protein 47
TPD52 tumor protein D52
TSPAN13 tetraspanin 13
TUSC3 tumor suppressor candidate 3
VWA5A von Willebrand factor A domain containing 5A
WDR61 WD repeat domain 61
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ADM adrenomedullin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4A ADP-ribosylation factor-like 4A
ARL4C ADP-ribosylation factor-like 4C
AURKA aurora kinase A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAMBI BMP and activin membrane-bound inhibitor
BARD1 BRCA1 associated RING domain 1
BCOR BCL6 corepressor
CBR3 carbonyl reductase 3
CCNE2 cyclin E2
CCNF cyclin F
CD44 CD44 molecule (Indian blood group)
CDC25A cell division cycle 25A
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDCA4 cell division cycle associated 4
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CELF2 CUGBP, Elav-like family member 2
CFLAR CASP8 and FADD-like apoptosis regulator
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CXCL12 chemokine (C-X-C motif) ligand 12
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP6 dual specificity phosphatase 6
E2F3 E2F transcription factor 3
EIF5 eukaryotic translation initiation factor 5
FBXO11 F-box protein 11
FBXO5 F-box protein 5
FOSL2 FOS-like antigen 2
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
H2AFX H2A histone family, member X
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXA1 homeobox A1
HOXA10 homeobox A10
HOXA5 homeobox A5
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
JAG1 jagged 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLHL9 kelch-like family member 9
LDLR low density lipoprotein receptor
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MTERF3 mitochondrial transcription termination factor 3
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NFIL3 nuclear factor, interleukin 3 regulated
NOP56 NOP56 ribonucleoprotein
PHLDA1 pleckstrin homology-like domain, family A, member 1
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PTPRO protein tyrosine phosphatase, receptor type, O
RAD51C RAD51 paralog C
RBM15 RNA binding motif protein 15
RPL37A ribosomal protein L37a
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSBN1 round spermatid basic protein 1
SAP30 Sin3A-associated protein, 30kDa
SCAF8 SR-related CTD-associated factor 8
SGK1 serum/glucocorticoid regulated kinase 1
SHB Src homology 2 domain containing adaptor protein B
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A2 solute carrier family 38, member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
STC1 stanniocalcin 1
SULF1 sulfatase 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TSC22D2 TSC22 domain family, member 2
XBP1 X-box binding protein 1
ZCCHC2 zinc finger, CCHC domain containing 2
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF217 zinc finger protein 217
ZNF232 zinc finger protein 232