BRD-K87909389_alvocidib_HS578T_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

134 genes differentially expressed following the BRD-K87909389_alvocidib_HS578T_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADORA2B adenosine A2b receptor
AK4 adenylate kinase 4
ALDOB aldolase B, fructose-bisphosphate
ANKRD10 ankyrin repeat domain 10
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ASCL1 achaete-scute family bHLH transcription factor 1
BAG3 BCL2-associated athanogene 3
BRD4 bromodomain containing 4
C10ORF2 chromosome 10 open reading frame 2
C1ORF116 chromosome 1 open reading frame 116
C7 complement component 7
CA2 carbonic anhydrase II
CCND1 cyclin D1
CD1E CD1e molecule
CD52 CD52 molecule
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHERP calcium homeostasis endoplasmic reticulum protein
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COASY CoA synthase
COLEC12 collectin sub-family member 12
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DEFA4 defensin, alpha 4, corticostatin
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EPHA3 EPH receptor A3
FRZB frizzled-related protein
G0S2 G0/G1 switch 2
GPX3 glutathione peroxidase 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HP haptoglobin
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IL1RN interleukin 1 receptor antagonist
KCTD5 potassium channel tetramerization domain containing 5
KIAA0125 KIAA0125
KLF10 Kruppel-like factor 10
KLHL21 kelch-like family member 21
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
LEF1 lymphoid enhancer-binding factor 1
LUC7L3 LUC7-like 3 (S. cerevisiae)
LYN LYN proto-oncogene, Src family tyrosine kinase
MALL mal, T-cell differentiation protein-like
MRFAP1L1 Morf4 family associated protein 1-like 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
P3H2 prolyl 3-hydroxylase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCP4 Purkinje cell protein 4
PDZK1IP1 PDZK1 interacting protein 1
PPIF peptidylprolyl isomerase F
PPIG peptidylprolyl isomerase G (cyclophilin G)
PRR7 proline rich 7 (synaptic)
PRRC2C proline-rich coiled-coil 2C
PRSS2 protease, serine, 2 (trypsin 2)
PTPRO protein tyrosine phosphatase, receptor type, O
RAB5C RAB5C, member RAS oncogene family
RASA4 RAS p21 protein activator 4
RBP4 retinol binding protein 4, plasma
RGS10 regulator of G-protein signaling 10
RIT1 Ras-like without CAAX 1
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELL selectin L
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPON1 spondin 1, extracellular matrix protein
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TNC tenascin C
TSPAN7 tetraspanin 7
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA2 annexin A2
ATF5 activating transcription factor 5
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
C10ORF10 chromosome 10 open reading frame 10
C2CD5 C2 calcium-dependent domain containing 5
C3ORF14 chromosome 3 open reading frame 14
CAST calpastatin
CLU clusterin
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DLC1 DLC1 Rho GTPase activating protein
ECI1 enoyl-CoA delta isomerase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM129A family with sequence similarity 129, member A
FZD7 frizzled class receptor 7
GAS1 growth arrest-specific 1
GNAS GNAS complex locus
GSTA4 glutathione S-transferase alpha 4
GTPBP8 GTP-binding protein 8 (putative)
H2AFV H2A histone family, member V
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGFBP7 insulin-like growth factor binding protein 7
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
MACF1 microtubule-actin crosslinking factor 1
MCAM melanoma cell adhesion molecule
MCM5 minichromosome maintenance complex component 5
MTUS1 microtubule associated tumor suppressor 1
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
NREP neuronal regeneration related protein
NT5DC2 5'-nucleotidase domain containing 2
NUPR1 nuclear protein, transcriptional regulator, 1
PCSK2 proprotein convertase subtilisin/kexin type 2
PFN2 profilin 2
PLA2G16 phospholipase A2, group XVI
PLS3 plastin 3
RHOB ras homolog family member B
RTN3 reticulon 3
SEPT10 septin 10
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMC4 structural maintenance of chromosomes 4
STAT1 signal transducer and activator of transcription 1, 91kDa
STMN1 stathmin 1
TMEM50A transmembrane protein 50A
TMSB15A thymosin beta 15a
WWTR1 WW domain containing transcription regulator 1