BRD-K87909389_alvocidib_HME1_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

203 genes differentially expressed following the BRD-K87909389_alvocidib_HME1_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRF5 adhesion G protein-coupled receptor F5
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CECR1 cat eye syndrome chromosome region, candidate 1
CETN3 centrin, EF-hand protein, 3
CLDN10 claudin 10
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
EHBP1 EH domain binding protein 1
EIF5A eukaryotic translation initiation factor 5A
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F8 coagulation factor VIII, procoagulant component
FAM171A1 family with sequence similarity 171, member A1
FOLR1 folate receptor 1 (adult)
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GUSBP3 glucuronidase, beta pseudogene 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KAZN kazrin, periplakin interacting protein
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT19 keratin 19, type I
LAMP3 lysosomal-associated membrane protein 3
LAPTM4B lysosomal protein transmembrane 4 beta
LRRC16A leucine rich repeat containing 16A
LTBP3 latent transforming growth factor beta binding protein 3
MAGEA6 melanoma antigen family A6
MAOA monoamine oxidase A
MSRB2 methionine sulfoxide reductase B2
MYO5C myosin VC
NMU neuromedin U
NUPR1 nuclear protein, transcriptional regulator, 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PLCB4 phospholipase C, beta 4
PODXL podocalyxin-like
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PROM1 prominin 1
PSENEN presenilin enhancer gamma secretase subunit
QPCT glutaminyl-peptide cyclotransferase
QPRT quinolinate phosphoribosyltransferase
RBP1 retinol binding protein 1, cellular
SCG2 secretogranin II
SLPI secretory leukocyte peptidase inhibitor
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX10 sorting nexin 10
SOX11 SRY (sex determining region Y)-box 11
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TMSB15A thymosin beta 15a
TPSAB1 tryptase alpha/beta 1
TSPAN13 tetraspanin 13
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
AGTR1 angiotensin II receptor, type 1
ARID4B AT rich interactive domain 4B (RBP1-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
BCOR BCL6 corepressor
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
CANT1 calcium activated nucleotidase 1
CAST calpastatin
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBR3 carbonyl reductase 3
CCL5 chemokine (C-C motif) ligand 5
CCNF cyclin F
CD8A CD8a molecule
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDKN2AIP CDKN2A interacting protein
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHD1 chromodomain helicase DNA binding protein 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CKS2 CDC28 protein kinase regulatory subunit 2
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EIF5 eukaryotic translation initiation factor 5
ELL2 elongation factor, RNA polymerase II, 2
FBXL12 F-box and leucine-rich repeat protein 12
FCGBP Fc fragment of IgG binding protein
FEM1C fem-1 homolog c (C. elegans)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO1 forkhead box O1
FZD7 frizzled class receptor 7
GAREM GRB2 associated, regulator of MAPK1
GAS1 growth arrest-specific 1
GNLY granulysin
GTF2B general transcription factor IIB
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HAUS3 HAUS augmin-like complex, subunit 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIC2 hypermethylated in cancer 2
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IER5 immediate early response 5
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
LDLR low density lipoprotein receptor
MAD2L1BP MAD2L1 binding protein
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7D1 MAP7 domain containing 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MIR22HG MIR22 host gene
MMP12 matrix metallopeptidase 12
MSMB microseminoprotein, beta-
MTF2 metal response element binding transcription factor 2
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NGDN neuroguidin, EIF4E binding protein
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP153 nucleoporin 153kDa
NUP98 nucleoporin 98kDa
OSER1 oxidative stress responsive serine-rich 1
PANX1 pannexin 1
PDGFA platelet-derived growth factor alpha polypeptide
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLIN2 perilipin 2
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PTX3 pentraxin 3, long
RAP2B RAP2B, member of RAS oncogene family
RBM12 RNA binding motif protein 12
RBM15 RNA binding motif protein 15
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RND3 Rho family GTPase 3
RNF19B ring finger protein 19B
RRAGC Ras-related GTP binding C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERTAD2 SERTA domain containing 2
SERTAD3 SERTA domain containing 3
SIK1 salt-inducible kinase 1
SIRT1 sirtuin 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBX3 T-box 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGIF1 TGFB-induced factor homeobox 1
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOB2 transducer of ERBB2, 2
TP63 tumor protein p63
TRAPPC3 trafficking protein particle complex 3
TSC22D2 TSC22 domain family, member 2
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VEGFA vascular endothelial growth factor A
VEZF1 vascular endothelial zinc finger 1
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2